王兆彬 - 西湖大学

个人简介

PROFESSIONAL EXPERIENCE 2019 – Present Assistant Professor Westlake University 2016 – 2019 Postdoctoral Fellow California Institute of Technology Advisor: Prof. Gregory C. Fu EDUCATION 2015 Ph.D. in Organic Chemistry, Hong Kong University of Science and Technology Advisor: Prof. Jianwei Sun 2011 B.S. in Chemistry, Nanjing University Advisor: Prof. Leyong Wang HONORS AND AWARDS 2023 Thieme Chemistry Journals Award

研究领域

Research in the Wang group focuses on the development of novel methodologies for organic synthesis and applying our new methods in synthesizing valuable molecules, such as biologically active compounds. We are particularly interested in transition-metal catalysis to improve synthetic efficiency, reaction selectivity, and sustainability. Representative research projects are as follows Radical-polar crossover in asymmetric synthesis Radicals are highly reactive intermediates and thus enable quick access to molecular complexity under mild conditions (e.g., photochemical, and electrochemical conditions). However, the stereoselectivity control of radical reactions remains a long-standing challenge. Our group is interested in developing asymmetric radical-involved reactions in the “Radical-Polar Crossover” manner. Specifically, we focus on the elementary step of single electron reduction of alkyl radials with transition metal complex to affording an alkyl M complex, followed by carbon-carbon or carbon-heteroatom bond formations. We also aim to understand the fundamental mechanisms of these processes to expedite catalytic system development as well as potential synthetic applications. Ti catalysis Titanium, the second most abundant transition metal and generally nontoxic, is an attractive catalyst for reaction development. However, Ti-based redox catalysis is difficult due to the stability of Ti(IV) state. Our lab is particularly interested in developing transformations of readily available carboxylic derivatives, olefins, and alkynes via Ti(II)/Ti(IV) redox catalysis. We also aim to understand the fundamental mechanisms behind these processes to facilitate potential catalytic applications.

近期论文

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“Chromium Catalyzed Asymmetric Reformatsky Reaction.” Lv, Y.-F.#; Liu, G.#; Shi, Z.; Wang, Z.*, Angew. Chem. Int. Ed. 2024,doi.org/10.1002/anie.202406109. “Fe-Catalyzed B-H and Si-H Insertion Reactions of gem-Dihaloalkanes” Wang, X.; Wang, Z.*, Org. Chem. Front. 2024, doi.org/10.1039/D4QO00136B. “Access to All-Carbon Quaternary Centers by Photocatalytic Fluoroalkylation of α-Halo Carbonyl Compounds” Liu, G.; Shen, H.; Wang, Z.*, Org. Lett. 2024, doi.org/10.1021/acs.orglett.4c00041. “A Radical Approach for Asymmetric α-C–H Addition of N-Sulfonyl Benzylamines to Aldehydes” Hu, H.#; Shi, Z.#; Guo, X.#; Zhang, F.-H.; Wang, Z.*, J. Am. Chem. Soc. 2024, 146, 5316-5323. “A Modular Approach to Stereoselective Homoaldol Reaction via Photoredox/Cr/Co Triple Catalysis” Shen, H.; Zhang, Z.; Shi, Z.; Gao, K.; Wang, Z.*, Chem 2024, doi.org/10.1016/j.chempr.2024.01.003. “Cr-Catalyzed Allylic C(sp3)–H Addition to Aldehydes Enabled by Photoinduced Ligand-To-Metal Charge Transfer” Zeng, X.#; Zhang, F.-H.#; Lai, R.; Lin, X.; Wang, Z.*, Sci. China Chem. 2023,doi.org/10.1007/s11426-023-1911-x accepted. “Cr-Catalyzed Asymmetric Cross Aza-Pinacol Couplings for β-Amino Alcohol Synthesis” Hu, H.; Wang, Z.*, J. Am. Chem. Soc. 2023, doi.org/10.1021/jacs.3c08493. “Ti-Catalyzed Modular Ketone Synthesis from Carboxylic Derivatives and gem-Dihaloalkanes” Ni, J.#; Xia, X.#; Gu, D.; Wang, Z.*, J. Am. Chem. Soc. 2023, 145, 14884-14893. “Catalytic Diastereo- and Enantioselective Cyclopropanation of gem-Dihaloalkanes and Terminal Olefins” Liu, H.-L.; Wang, X.; Gao, K.; Wang, Z.*, Angew. Chem. Int. Ed. 2023, doi.org/10.1002/anie.202305987. “Cr-Catalyzed Regio-, Diastereo-, and Enantioselective Reductive Couplings of Ketones and Propargyl Halides” Guo, X.#; Shi, Z.#; Zhang, F.-H.; Wang, Z.*, ACS Catal. 2023, 13, 3170-3178. (# co-first author) Cr-Catalyzed Chiral Allenone Synthesis via Sequential Radical-Polar Crossover and Oppenauer Oxidation" Zeng, X.; Zhang, F.-H.*; Wang, Z.*, Org. Chem. Front. 2023, 10, 310-316. (Invited submission, Frontiers Emerging Investigators Series) “Cr-Catalyzed Diastereo- and Enantioselective Synthesis of β-Hydroxy Sulfides and Selenides.” Xia, X.; Wang, Z.*, ACS Catal. 2022, 12, 11152-11158. “Asymmetric 1,4-Funcitonalization of 1,3-Enynes via Dual Photoredox and Chromium Catalysis.” Zhang, F.-H.#; Guo, X.#; Zeng, X.; Wang, Z.*, Nat. Commun. 2022, 13, 5036. (# co-first author) “Ti-Catalyzed Diastereoselective Cyclopropanation of Carboxylic Derivatives with Terminal Olefins.”Ni, J.; Xia, X.; Zheng, W.-F.; Wang, Z.*, J. Am. Chem. Soc. 2022,144, 7889–7900. "Catalytic Enantioconvergent Allenylation of Aldehydes with Propargyl Halides.” Zhang, F.-H.; Guo, X.; Zeng, X.; Wang, Z.*, Angew. Chem. Int. Ed. 2022, 61, e202117114. “Quaternary Stereocentres via Catalytic Enantioconvergent Nucleophilic Substitution Reactions of Tertiary Alkyl Halides” Wang, Z.; Yang, Z-P.; Fu, G. C.*, Nat. Chem. 2021,13, 236-242. “Catalytic Enantioconvergent Couplings of Secondary and Tertiary Electrophiles with Olefins” Wang, Z.; Yin, H.; Fu, G. C.*, Nature 2018, 563, 379−383. “Nickel-Catalyzed Enantioconvergent Borylation of Racemic Secondary Benzylic Electrophiles” Wang, Z.; Bachman, S.; Dudnik, A. S.; Fu, G. C.*, Angew. Chem. Int. Ed. 2018, 57, 14529−14532. “Catalytic Asymmetric 1,6-Conjugate Addition of para-Quinone Methides: Formation of All-Carbon Quaternary Stereocenters”, Wang, Z.; Wong, Y. F.; Sun, J.* , Angew. Chem., Int. Ed. 2015, 54, 13711−13714. (Highlighted in SYNFACTS) “Catalytic Enantioselective Intermolecular Desymmetrization of Azetidines”, Wang, Z.; Sheong, F.; Sung, H.; Williams, I.; Lin, Z.; Sun, J.*, J. Am. Chem. Soc. 2015, 137, 5895−5898. “Organocatalytic Asymmetric Synthesis of 1,1-Diarylethanes by Transfer Hydrogenation”, Wang, Z.; Ai, F.; Wang, Z.; Zhao, W.; Zhu, G.; Lin, Z.; Sun, J.*, J. Am. Chem. Soc. 2015, 137, 383−389. “Catalytic Enantioselective Intermolecular Desymmetrization of 3-Substituted Oxetanes”, Wang, Z.; Chen, Z.; Sun, J.*, Angew. Chem. Int. Ed. 2013, 52, 6685−6688. “Enantioselective [4+2] Cycloaddition of o-Quinone Methides and Vinyl Sulfides: Indirect Access to Generally Substituted Chiral Chromanes”, Wang, Z.; Sun, J.*, Org. Lett. 2017, 19, 2334−2337. “Organocatalytic Enantioselective Desymmetrization of meso-Aziridines and Prochiral Azetidines”, Wang, Z.; Hong, W.-X.; Sun, J.*, Curr. Org. Chem. 2016, 20, 1851−1861. “Recent Advances in Catalytic Asymmetric Reactions of o-Quinone Methides”, Wang, Z.; Sun, J.*, Synthesis 2015, 47, 3629−3644. “Catalytic Asymmetric Nucleophilic Opening of 3-Substituted Oxetanes”, Wang, Z.; Chen, Z.; Sun, J.*, Org. Biomol. Chem. 2014, 12, 6208−6032. “Chiral Phosphoric Acid Catalyzed Enantioselective Desymmetrization of meso-Epoxides by Thiols”, Wang, Z.; Law, W. K.; Sun, J.*, Org. Lett. 2013, 15, 5964−5966. “An Organocatalytic Kinetic Resolution of Aziridines by Thiol Nucleophiles”, Sun, S.1; Wang, Z.1 (co-first author); Li, S.; Zhou, C.; Song, L.; Huang, H.*; Sun, J.*, Org. Lett. 2020, acs.orglett.0c04074. “Catalytic Enantioselective Synthesis of Tetrahydroisoquinolines and Their Analogues Bearing a C4 Stereocenter: Formal Synthesis of (+)-(8S, 13R)-Cyclocelabenzine”, Chen, Z.1; Wang, Z.1 (co-first author); Sun, J.*, Chem. −Eur. J. 2013, 19, 8426−8430. “Enantioselective Chloride Opening of Oxetanes: Unusual Use of Wet Molecular Sieves for Controlled Release of HCl”, Yang, W.; Wang, Z.; Sun, J.*, Angew. Chem. Int. Ed. 2016, 55, 6954-6958. “Chiral Phosphoric Acid Catalyzed Asymmetric Addition of Naphthols to p-Quinone Methides”, Wong, Y. F.; Wang, Z.; Sun, J.*, Org. Biomol. Chem. 2016, 14, 5751−5754. “A One-Pot Oxidation/Cycloaddition Synthesis of 2,4-Diary Chromans Via ortho-Quinone Methides”, Wong, Y. F.; Wang, Z.; Hong, W. –X.; Sun, J.*, Tetrahedron 2016, 72, 2748−2751. “Organocataytic Asymmetric Nucleophilic Addition to ortho-Quinone Methides by Alcohols”, Lai, Z.; Wang, Z.; Sun, J.*, Org. Lett. 2015, 17, 6058−6061. “Enantioselective Formation of All-Carbon Quaternary Stereocenters from Indoles and Tertiary Alcohols Bearing A Directing Group”, Zhao, W.; Wang, Z.; Chu, B.; Sun, J.*, Angew. Chem. Int. Ed. 2015, 54, 1910−1913. “Organocatalytic Enantio- and Diastereoselective Synthesis of 1,2-Dihydronapthalenes from Isobenzopyrylium Ions”, Qian, H.; Zhao, W.; Wang, Z.; Sun, J.*, J. Am. Chem. Soc. 2015, 137, 560−563.