Tian, Bing - University of Texas Medical Branch - Department of Biochemistry and Molecular Biology

个人简介

More recently, he has focused his research on the molecular mechanisms of Chronic obstructive pulmonary disease (COPD) and asthma-associated airway remodeling/lung fibrosis. Using multiple experimental approaches, he has delineated the central role of the NFκB-BRD4 signaling pathway in the chronic airway inflammation-induced mesenchymal transition of epithelial cells and have linked this signaling pathway with airway remodeling/pulmonary fibrosis in vivo. Also, he has identified and developed highly specific BRD4 inhibitors (BRD4i) which significantly revered the viral infection and allergen induced airway inflammation/lung fibrosis. Furthermore, he has developed nanoparticle-encapsulated BRD4 inhibitors as novel nano-medications for treatment of IBD patients.

研究领域

Dr. Bing Tian received his Ph.D. degree in 1999 from UTMB. He is an expert of cellular and molecular biology/virology, mucosal innate signaling, small-animal models, and drug development. Also, he is a pharmacologist with formal pharmacology training. He has been working on the virus-, allergen-, and cytokine-induced innate immune response in the airway epithelium and signaling pathways of other chronic diseases for over 20 years, and has made substantial contributions to this field, with over 60 publications, an H-index of 28 and 2800 citations as well as 4 patents. He has focused on the following research fields: A). The Nuclear factor-κB (NFκB) signaling pathway in chronic diseases. B). Systems Biology of Airway epithelial–mesenchymal transition (EMT). C). Bromodomain-containing protein 4 (BRD4) Inhibitors and Chronic Airway inflammation-induced Remodeling/Pulmonary Fibrosis. D). Viral and allergen infection-related pulmonary inflammation and disease. E) Novel therapeutics of inflammatory bowel diseases (IBD).

近期论文

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Liu Z, Li Y, Chen H, Lai HT, Wang P, Wu SY, Wold EA, Leonard PG, Joseph S, Hu H, Chiang CM, Brasier AR, Tian B, Zhou J. Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site. J Med Chem. 2022 Jan 4;. doi: 10.1021/acs.jmedchem.1c01851. [Epub ahead of print] PubMed PMID: 34982556. Li Y, Chen J, Bolinger AA, Chen H, Liu Z, Cong Y, Brasier AR, Pinchuk IV, Tian B, Zhou J. Target-Based Small Molecule Drug Discovery Towards Novel Therapeutics for Inflammatory Bowel Diseases. Inflamm Bowel Dis. 2021 Nov 15;27(Suppl 2):S38-S62. doi: 10.1093/ibd/izab190. Review. PubMed PMID: 34791293. Covarrubias-Zambrano O, Motamedi M, Ameredes BT, Tian B, Calhoun WJ, Zhao Y, Brasier AR, Kalubowilage M, Malalasekera AP, Yapa AS, Wang H, Culbertson CT, Troyer DL, Bossmann SH. Optical biosensing of markers of mucosal inflammation. Nanomedicine. 2021 Nov 4;40:102476. doi: 10.1016/j.nano.2021.102476. [Epub ahead of print] PubMed PMID: 34743019. Luo H, Li G, Wang B, Tian B, Gao J, Zou J, Shi S, Zhu S, Peng BH, Adam A, Martinez A, Hein K, Winkelmann ER, Mahmoud Y, Zhou X, Shan C, Rossi S, Weaver S, Barrett ADT, Sun SC, Zhang W, Shi PY, Wu P, Wang T. Peli1 signaling blockade attenuates congenital zika syndrome. PLoS Pathog. 2020 Jun;16(6):e1008538. doi: 10.1371/journal.ppat.1008538. eCollection 2020 Jun. PubMed PMID: 32544190; PubMed Central PMCID: PMC7297310. Liu Z, Chen H, Wang P, Li Y, Wold EA, Leonard PG, Joseph S, Brasier AR, Tian B, Zhou J. Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation. J Med Chem. 2020 May 28;63(10):5242-5256. doi: 10.1021/acs.jmedchem.0c00035. Epub 2020 Apr 22. PubMed PMID: 32255647; PubMed Central PMCID: PMC7989030. Sowers ML, Tang H, Tian B, Goldblum R, Midoro-Horiuti T, Zhang K. Bisphenol A Activates an Innate Viral Immune Response Pathway. J Proteome Res. 2020 Feb 7;19(2):644-654. doi: 10.1021/acs.jproteome.9b00548. Epub 2019 Dec 27. PubMed PMID: 31816243; PubMed Central PMCID: PMC8311900. Zhao Y, Tian B, Sun H, Zhang J, Zhang Y, Ivannikov M, Motamedi M, Liu Z, Zhou J, Kaphalia L, Calhoun WJ, Maroto R, Brasier AR. Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling. J Proteomics. 2019 Aug 15;205:103415. doi: 10.1016/j.jprot.2019.103415. Epub 2019 Jun 10. PubMed PMID: 31195152; PubMed Central PMCID: PMC6699176. Niu Q, Liu Z, Alamer E, Fan X, Chen H, Endsley J, Gelman BB, Tian B, Kim JH, Michael NL, Robb ML, Ananworanich J, Zhou J, Hu H. Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV. J Clin Invest. 2019 Jul 22;129(8):3361-3373. doi: 10.1172/JCI120633. eCollection 2019 Jul 22. PubMed PMID: 31329163; PubMed Central PMCID: PMC6668673. Tian B, Hosoki K, Liu Z, Yang J, Zhao Y, Sun H, Zhou J, Rytting E, Kaphalia L, Calhoun WJ, Sur S, Brasier AR. Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling. J Allergy Clin Immunol. 2019 Apr;143(4):1380-1394.e9. doi: 10.1016/j.jaci.2018.09.029. Epub 2018 Oct 13. PubMed PMID: 30321559; PubMed Central PMCID: PMC6490683. Tian B, Liu Z, Litvinov J, Maroto R, Jamaluddin M, Rytting E, Patrikeev I, Ochoa L, Vargas G, Motamedi M, Ameredes BT, Zhou J, Brasier AR. Efficacy of Novel Highly Specific Bromodomain-Containing Protein 4 Inhibitors in Innate Inflammation-Driven Airway Remodeling. Am J Respir Cell Mol Biol. 2019 Jan;60(1):68-83. doi: 10.1165/rcmb.2017-0445OC. PubMed PMID: 30153047; PubMed Central PMCID: PMC6348724. Tian B, Widen SG, Yang J, Wood TG, Kudlicki A, Zhao Y, Brasier AR. The NFκB subunit RELA is a master transcriptional regulator of the committed epithelial-mesenchymal transition in airway epithelial cells. J Biol Chem. 2018 Oct 19;293(42):16528-16545. doi: 10.1074/jbc.RA118.003662. Epub 2018 Aug 30. PubMed PMID: 30166344; PubMed Central PMCID: PMC6200927. Ochoa LF, Kholodnykh A, Villarreal P, Tian B, Pal R, Freiberg AN, Brasier AR, Motamedi M, Vargas G. Imaging of Murine Whole Lung Fibrosis by Large Scale 3D Microscopy aided by Tissue Optical Clearing. Sci Rep. 2018 Sep 6;8(1):13348. doi: 10.1038/s41598-018-31182-2. PubMed PMID: 30190498; PubMed Central PMCID: PMC6127188. Graber TG, Rawls BL, Tian B, Durham WJ, Brightwell CR, Brasier AR, Rasmussen BB, Fry CS. Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia. Exp Gerontol. 2018 Jun;106:88-100. doi: 10.1016/j.exger.2018.02.002. Epub 2018 Feb 13. PubMed PMID: 29452288; PubMed Central PMCID: PMC5911410. Tian B, Yang J, Zhao Y, Ivanciuc T, Sun H, Wakamiya M, Garofalo RP, Brasier AR. Central Role of the NF-κB Pathway in the Scgb1a1-Expressing Epithelium in Mediating Respiratory Syncytial Virus-Induced Airway Inflammation. J Virol. 2018 Jun 1;92(11). doi: 10.1128/JVI.00441-18. Print 2018 Jun 1. PubMed PMID: 29593031; PubMed Central PMCID: PMC5952137. Liu Z, Tian B, Chen H, Wang P, Brasier AR, Zhou J. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur J Med Chem. 2018 May 10;151:450-461. doi: 10.1016/j.ejmech.2018.04.006. Epub 2018 Apr 3. PubMed PMID: 29649741; PubMed Central PMCID: PMC5924617. Tian B, Liu Z, Yang J, Sun H, Zhao Y, Wakamiya M, Chen H, Rytting E, Zhou J, Brasier AR. Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation. Cell Rep. 2018 Apr 24;23(4):1138-1151. doi: 10.1016/j.celrep.2018.03.106. PubMed PMID: 29694891; PubMed Central PMCID: PMC6020052. Zhang K, Xu P, Sowers JL, Machuca DF, Mirfattah B, Herring J, Tang H, Chen Y, Tian B, Brasier AR, Sowers LC. Proteome Analysis of Hypoxic Glioblastoma Cells Reveals Sequential Metabolic Adaptation of One-Carbon Metabolic Pathways. Mol Cell Proteomics. 2017 Nov;16(11):1906-1921. doi: 10.1074/mcp.RA117.000154. Epub 2017 Sep 5. PubMed PMID: 28874504; PubMed Central PMCID: PMC5671999. Liu Z, Wang P, Chen H, Wold EA, Tian B, Brasier AR, Zhou J. Drug Discovery Targeting Bromodomain-Containing Protein 4. J Med Chem. 2017 Jun 8;60(11):4533-4558. doi: 10.1021/acs.jmedchem.6b01761. Epub 2017 Mar 2. Review. PubMed PMID: 28195723; PubMed Central PMCID: PMC5464988. Yang J, Tian B, Sun H, Garofalo RP, Brasier AR. Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition. Nat Microbiol. 2017 Jun 5;2:17086. doi: 10.1038/nmicrobiol.2017.86. PubMed PMID: 28581456; PubMed Central PMCID: PMC5501188. Tian B, Patrikeev I, Ochoa L, Vargas G, Belanger KK, Litvinov J, Boldogh I, Ameredes BT, Motamedi M, Brasier AR. NF-κB Mediates Mesenchymal Transition, Remodeling, and Pulmonary Fibrosis in Response to Chronic Inflammation by Viral RNA Patterns. Am J Respir Cell Mol Biol. 2017 Apr;56(4):506-520. doi: 10.1165/rcmb.2016-0259OC. PubMed PMID: 27911568; PubMed Central PMCID: PMC5449514. Tian B, Yang J, Zhao Y, Ivanciuc T, Sun H, Garofalo RP, Brasier AR. BRD4 Couples NF-κB/RelA with Airway Inflammation and the IRF-RIG-I Amplification Loop in Respiratory Syncytial Virus Infection. J Virol. 2017 Mar 15;91(6). doi: 10.1128/JVI.00007-17. Print 2017 Mar 15. PubMed PMID: 28077651; PubMed Central PMCID: PMC5331805.