古丽娟 - 武汉大学 - 人民医院中心实验室

个人简介

浙江大学与美国斯坦福大学医学院联合培养博士，主要从事脑缺血再灌注损伤后脑组织炎症反应和外周免疫抑制的发生机制及二者相互关系研究，以期开发有效的神经保护措施；获得国家自然科学基金资助4项、湖北省自然科学基金资助1项。发表论文40余篇，其中在神经科学Top杂志《Stroke》等发表SCI论文37篇；成果《缺血性脑损伤与免疫调控的机制与防治》获2020年湖北省科技进步三等奖；发表译著《探索对与错的真相：重新审视麻醉学中的经典内容》。具有国内外指导本科生和研究生科研活动的丰富经验，已指导本科生或研究生26人，其中12人已顺利毕业，并能为学生进一步出国深造提供帮助。教育履历 1991.09-1996.07山西医科大学临床医学专业本科生获学士学位 2002.09-2005.06浙江大学医学院内科学硕士研究生获硕士学位 2006.09-2012.06浙江大学医学院免疫学博士研究生获博士学位 (2009.01-2012.02美国斯坦福大学医学院神经外科，联合培养博士) 工作履历 1996.07-2002.08山西省阳泉市第一人民医院神经内科住院及主治医师 2009.01-2012.02美国斯坦福大学医学院神经外科，联合培养博士兼研究助理(Department of Neurosurgery，Stanford University School of Medicine，Joint Ph.D and Research Assistant) 2012.08-2015.02杭州师范大学医学院病理学教研室，讲师（D类人才引进） 2015/03至今武汉大学人民医院中心实验室，副教授

研究领域

1.缺血性脑卒中的发病机制：主要关注缺血性脑卒中的免疫学发生机制，尤其是T淋巴细胞在缺血性脑卒中以及脑缺血再灌注损伤中的作用和机制研究。 2.缺血性脑卒中对免疫系统的影响：重点研究和探索缺血性脑卒中诱导的外周免疫抑制的发生机制和靶向干预措施。

近期论文

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Zhong Y#, Yin B#, Ye YZ, Omar D, Xiong XX, Jian ZH*, Gu LJ*. The bidirectional role of the JAK2/STAT3 signaling pathway and related mechanisms in cerebral ischemia-reperfusion injury. Experimental Neurology.2021;113690(*通讯作者) 2.Xu QX, Zhao B, Ye YZ, Li YN, Zhang YG, Xiong XX*, Gu LJ*. Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke. J Neuroinflamm. 2021;18: 123(*通讯作者) Zhou Y, Ye YZ, Zhu XQ, Jin T, Yi Wei, Gu LJ, Xiong XX. Meisoindigo inhibits cellular proliferation via down-regulation of the PI3K/Akt pathway and induces cellular apoptosis in glioblastoma U87 cells. Acta Biochim Pol. 2021; 68(2): 309-315 (*通讯作者） Zhu H#, Zhang YG#, Zhong Y, Ye YZ, Hu XY, Xiong XX*, Gu LJ*. Inflammation- mediated angiogenesis in ischemic stroke. Front Cell Neurosci. 2021.652647 (*通讯作者) WangL,XiongXX,ZhangX,YeYZ,JianZH,GaoWW,GuLJ*. Sodium Tanshinone IIA Sulfonate Protects Against Cerebral Ischemia–reperfusion Injury by Inhibiting Autophagy and Inflammation. Neuroscience. 2020;44:46-57 (*通讯作者) Zeng Z, Zhang X, Li D, Li Jin, Yuan JP, Gu LJ*, Xiong XX. Expression, location, clinical implication and bioinformatics analysis of RNASET2 in gastric adenocarcinoma. Front. Oncol. 2020;10:836. (*通讯作者) Wu LQ, Xiong XX, Wu XM, Ye YZ, Jian ZH, Zeng Z, Gu LJ*. Targeting oxidative stress and inflammation to prevent ischemia-reperfusion injury. Front Mol Neurosci.2020;13: 28. (*通讯作者) Ye YZ#, Jin T#, Zhang X, Zeng Z, Ye BX, Wang JC, Zhong Y, Xiong XX*, Gu LJ*. Meisoindigo protects againstfocal cerebral ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation and regulating microglia/macrophage polarization via TLR4/NF-κB aignaling pathway. Front Cell Neurosci 2019;13: 553. (*通讯作者) Ye YZ#, Zeng Z#, Jin T, Zhang HF, Xiong XX*, Gu LJ*, The role of high mobility group box 1 in ischemic stroke. Front Cell Neurosc.2019 Apr 2;13:127.(*通讯作者) Gu LJ, Tao Yu, Chen C, Ye YZa, Xiong XX, Sun Yao. Initiation of the inflammatory response after renal ischemia/reperfusion injury during renal transplantation. Int Urol Nephrol. 2018 Nov;50(11):2027-2035. Fang CC#, Gu LJ#, Smerin D, Mao SP, and Xiong XX. The Interrelation between Reactive Oxygen Species and Autophagy in Neurological Disorders. Oxid Med Cell Long. Volume 2017 (2017), Article ID 8495160, 16 pages（#共同第一作者） Ye BX, Stary CM, Gao QP, Wang QY, Zeng Z, Jian ZH, Gu LJ* and Xiong XX. Genetically modified T cell-based adoptive immunotherapy in hematological malignancies. J Immunol Res. 2017;2017:5210459 (*通讯作者) Xiong XX#, Gu LJ#, Wang Y, Luo Y, Zhang HF, Lee J, Krams SM, Zhu SM, Zhao H. Glycyrrhizin protects against focal cerebral ischemia via inhibition of T cell activity and HMGB1-mediated mechanisms. J Neuroinflammation. 2016 Sep 8;13(1):241 (#共同第一作者) Ye BX, Gao QP, Zeng Z, Stary CM, Jian ZH, Xiong XX, Gu LJ*. Single-Cell Sequencing Technology in Oncology: Applications for Clinical Therapies and Research. Anal Cell Pathol (Amst). 2016;2016: 9369240. (*通讯作者) Jian ZH, Ding S, Deng HP, Wang J, Yi W, Wang L, Zhu SM, Gu LJ*, Xiong XX*. Probenecid protects against oxygen-glucose deprivation injury in primary astrocytes by regulating inflammasome activity. Brain Res. 2016;1643:123-129. (*通讯作者) Gu LJ, Jian ZH, Stary C, Xiong XX.T Cells and Cerebral Ischemic Stroke. Neurochem Res. 2015;40(9):1786-91. Gu LJ, Xiong XX, Ito T, Lee J, Xu BH, Krams S, Steinberg GK, Zhao H. Moderate hypothermia inhibits brain inflammation and attenuates stroke-induced immunodepression in rats. CNS Neurosci Ther. 2014; 20:67-75. Gu LJ, Xiong XX, Wei DT, Gao XW, Krams S, Zhao H. T cells contribute to stroke-induced lymphopenia in rats. PloS one. 2013; 8:e59602. Xiong XX#, Gu LJ#, Zhang HF, Xu BH, Zhu SM, Zhao H. The protective effects of t cell deficiency against brain injury are ischemic model-dependent in rats. Neurochem Int. 2013; 3:265-270. (#共同第一作者) Gu LJ, Xiong XX, Zhang HF, Xu BH, Steinberg GK, Zhao H. Distinctive effects of t cell subsets in neuronal injury induced by cocultured splenocytes in vitro and by in vivo stroke in mice. Stroke. 2012; 43:1941-1946.