Lou, Chenguang - University of Southern Denmark - Department of Physics, Chemistry and Pharmacy

个人简介

Education (Academic qualifications) Nucleic acid Chemistry, Doctor of Philosophy, University of Southampton Oct 2007 → sep. 2011 Date of graduation: 19 Sep. 2011 Medicinal Chemistry, Master of Philosophy, Beijing Union Medical College aug. 2003 → jul. 2006 Date of graduation: 1. jul. 2006 External employment Research Fellow, University of Southampton 1 May 2011 → 31 Dec. 2012

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Polyamine-Functionalized 2′-Amino-LNA in Oligonucleotides: Facile Synthesis of New Monomers and High-Affinity Binding towards ssDNA and dsDNA. Danielsen, MB , Christensen, NJ , Jørgensen, PT , Jensen, KJ , Wengel, J. & Lou, C. , 18 Jan. 2021 , I: Chemistry - A European Journal. 27 , 4 , pp. 1416-1422 Albumin-binding fatty acid – modified gapmer antisense oligonucleotides for modulation of pharmacokinetics. Cai, Y. , Lou, C. , Wengel, J. & Howard, KA , 2020 , Gapmers: Methods and Protocols. Yokota, T. & Maruyama, R. (Eds.). Humana Press , pp. 163-174 (Methods in Molecular Biology, Volume 2176). Gapmer Antisense Oligonucleotides Containing 2 ′, 3′-Dideoxy-2′-fluoro-3′-C-hydroxymethyl-β-d-lyxofuranosyl Nucleotides Display Site-Specific RNase H Cleavage and Induce Gene Silencing. Danielsen, MB , Lou, C. , Lisowiec-Wachnicka, J. , Pasternak, A. , Jørgensen, PT & Wengel, J. , 27. jan. 2020 , I: Chemistry - A European Journal. 26 , 6 , pp. 1368-1379 12 p. NickFect type of cell-penetrating peptides present enhanced efficiency for microRNA-146a delivery into dendritic cells and during skin inflammation. Carreras-Badosa, G. , Maslovskaja, J. , Periyasamy, K. , Urgard, E. , Padari, K. , Vaher, H. , Tserel, L. , Gestin, M. , Kisand, K. , Arukuusk, P . , Lou, C. , Langel, Ü. , Wengel, J. , Pooga, M. & Rebane, A. , dec. 2020 , I: Biomaterials. 262 , 120316. Self-Assembly of DNA – Peptide Supermolecules: Coiled-Coil Peptide Structures Templated by d-DNA and l-DNA Triplexes Exhibit Chirality-Independent but Orientation-Dependent Stabilizing Cooperativity. Lou, C. , Boesen, JT , Christensen, NJ , Sørensen, KK , Thulstrup, PW , Pedersen, MN , Giralt, E. , Jensen, KJ & Wengel, J. , 4. apr. 2020 , I: Chemistry - A European Journal. 26 , 25 , pp. 5676-5684 Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions. Ejlersen, M. , Lou, C. , Sanghvi, YS , Tor, Y. & Wengel, J. , 12 July. 2018 , I: Chemical Communications. 54 , 57 , pp. 8003-8006 Peptide-Oligonucleotide Conjugates as Nanoscale Building Blocks. Boesen, J. , Sorensen, K. , Lou, C. , Wengel, J. & Jensen, KJ , 1. sep. 2018 , I: Journal of Peptide Science. 24 , Suppl. 2 , pp. S157 1 p. Synergy of Two Highly Specific Biomolecular Recognition Events: Alignment of AT-Hook Peptide in DNA Minor Grooves via Covalent Conjugation to 2'-Amino-LNA. Ejlersen, M. , Christensen, NJ , Sørensen, KK , Jensen, KJ , Wengel, J. & Lou, C. , 2018 , In: Bioconjugate Chemistry. 29 , 4 , pp. 1025–1029 Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex. Lou, C. , Christensen, NJ , Martos-Maldonado, MC , Midtgaard, SR , Ejlersen, M. , Thulstrup, PW , Sørensen, KK , Jensen, KJ & Wengel, J. , 2017 , In: Chemistry: A European Journal . 23 , 39 , pp. 9297–9305 Oligonucleotides Containing Aminated 2'-Amino-LNA Nucleotides: Synthesis and Strong Binding to Complementary DNA and RNA. Lou, C. , Samuelsen, SV , Christensen, NJ , Vester, B. & Wengel, J. , 2017 , I: Bioconjugate Chemistry. 28 , 4 , pp. 1214-1220 Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes. Geny, S. , Moreno, PMD , Krzywkowski, T. , Gissberg, O. , Andersen, NK , Isse, AJ , El-Madani, AM , Lou, C. , Pabon, YV , Anderson, BA , Zaghloul, EM , Zain, R. , Hrdlicka, PJ , Jørgensen, PT , Nilsson, M. , Lundin, KE , Pedersen, EB , Wengel, J. & Smith, CIE , 18 Mar. 2016 , I:Nucleic Acids Research. 44,5,pp. 2007-2019 Peptide-oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic. Lou, C. , Martos-Maldonado, MC , Madsen, CS , Thomsen, RP , Midtgaard, SR , Christensen, NJ , Kjems, J. , Thulstrup, PW , Wengel, J. & Jensen, KJ , 2016 , In: Nature Communications. 7 , pp. 1-9 12294. Synthesis and Biophysical Investigations of Oligonucleotides Containing Galactose-Modified DNA, LNA and 2'-Amino-LNA Monomers. Ries, A. , Kumar, R. , Lou, C. , Kosbar, T. , Vengut-Climent, E. , Jørgensen, PT , Morales, JC & Wengel, J. , 13 Oct. 2016 , I: The Journal of Organic Chemistry. 81 , 22 , pp. 10845-10856 Oligonucleotides containing a piperazino-modified 2'-amino-LNA monomer exhibit very high duplex stability and remarkable nuclease resistance. Lou, C. , Vester, B. & Wengel, J. , Feb. 9; 2015 , I: Chemical Communications. 51 , 19 , pp. 4024-4027 Enhanced H-bonding and pi-stacking in DNA: a potent duplex-stabilizing and mismatch sensing nucleobase analogue. Lou, C. , Dallmann, A. , Marafini, P. , Gao, R. & Brown, T. , aug. 2014 , I: Chemical Science. 5 , 10 , pp. 3836-3844 9 p. 2 '-Aminoethoxy-2-amino-3-methylpyridine in Triplex-Forming Oligonucleotides: High Affinity, Selectivity and Resistance to Enzymatic Degradation. Lou, C. , Shelbourne, M. , Fox, KR & Brown, T. , dec. 2011 , I: Chemistry: A European Journal. 17 , 52 , pp. 14851-14856 6 p. 2′-Substituted 2-amino-3-methylpyridine ribonucleosides in triplex-forming oligonucleotides: triplex stability is determined by chemical environment. Lou, C. , Xiao, Q. , Tailor, RR , Ben Gaied, N. , Gale, N. , Light, ME , Fox, KR & Brown, T. , jun. 2011 , In: MedChemComm. 2 , 6 , pp. 550-558 9 p.