王学路 - 河南大学 - 作物逆境适应与改良国家重点实验室

个人简介

王学路，教授，博士生导师，教育部“长江学者”特聘教授，国家杰出青年基金获得者。2000年美国亚利桑那大学获博士学位; 2001-2006年在美国Howard Hughes Medical Institute，The Salk Institute从事博士后研究; 2007-2014年复旦大学生命科学学院，教授；2014-2019年华中农业大学生命科学学院，院长，教授；2019年12月加入河南大学作物逆境适应与改良国家重点实验室，生命科学学院，教授。以豆科植物和拟南芥为主要研究系统，采用遗传学、生物化学、细胞和发育生物学、生物信息学和结构生物学等方法，长期从事菌植互作与生物固氮、豆科生物学和植物激素信号转导网络及其调控生长发育的机制研究。揭示了油菜素甾醇信号转导网络及其调控植物雄性育性、根毛发育和水稻株型的遗传和分子机制；揭示了油菜素甾醇与脱落酸信号途径互作以及逆境下植物生长发育和环境适应性的遗传和分子机制；发现了油菜素甾醇与独脚金内酯信号途径互作调控植物分枝的分子机制。在Science、Development Cell（5）、PNAS（5）、Nature Communications, eLife, Genes & Development、Plant Cell（2）、Molecular Plant（9）和New Phytologist（2）等国际主流期刊发表50篇重要研究论文，引用三千多次。主持国家自然基金委杰出青年基金、重点基金、国际合作和重大研究计划集成项目；主持科技部““973”项目课题和政府间国际科技创新合作重点专项项目；主持上海市“浦江计划”和上海市优秀学科带头人项目；主持农业部“农业杰出人才与创新团队”；入选国家百千万人才工程“有突出贡献中青年专家”；享受国务院特殊津贴。

研究领域

生物固氮与菌植互作；豆科生物学与品种分子设计；激素与逆境信号互作网路及其调控植物发育机制；

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

代表性研究论文和著作(*为通讯作者)： Fang, Z., Ji, Y., Hu, J., Guo, R., Sun, S.* and Wang, X.* (2019). “Strigolactones and brassinosteroids antagonistically regulate the stability of D53-OsBZR1 complex to determine FC1 expression in rice tillering.” Mol Plant. S1674-2052(19)30401-0. PMID: 31837469 Hu, J., Ji, Y., Hu, X., Sun, S. * and Wang, X.* (2019). “BES1 functions as co-regulator of D53-like SMXLs to inhibit BRC1 expression in strigolactone-regulated shoot branching in Arabidopsis.” Plant Communications. https://doi.org/10.1016/j.xplc.2019.100014 Wu, Z., Wang, M., Yang, S., Chen, S., Chen, X., Liu, C., Wang, S., Wang, H., Zhang, B., Liu, H., Qin, R., and Wang, X.* (2019). “A global co-expression network of soybean genes gives insight into the evolution of nodulation in non-legumes and legumes.” New Phytologist. 223(4):2104-2119. PMID: 30977533   Song, S., Wang, H., Sun, M., Tang, J., Zheng, B., Wang, X.* and Yan-Wen Tan (2019). “Reactive oxygen species-mediated BIN2 activity revealed by single-molecule analysis.” New Phytologist. 223(2):692-704. PMID: 30597572 Sun, S.#, Wang, T.#, Wang, L., Li, X., Jia, Y., Liu, C., Huang, X., Xie, W. and Wang X.* (2018). “Natural Selection of a GSK3 Determines Rice Mesocotyl Domestication by Coordinating Strigolactone and Brassinosteroid Signaling.” Nature Communications. 9(1):2523. PMID: 29955063 Wang, H. and Wang, X.* (2018). “GSK3-like Kinases Are a Class of Positive Components in the Core ABA Signaling Pathway.” Mol Plant. 11(6):761-763. PMID: 29625191 Wang, H., Tang, J., Liu, J., Hu, J., Liu, J., Chen, Y., Cai, Z. and Wang, X.* (2017). "Abscisic Acid Signaling Inhibits Brassinosteroid Signaling through Dampening the Dephosphorylation of BIN2 by ABI1 and ABI2." Mol Plant. 11(2):315-325. PMID: 29275167 Yang, M. and Wang, X.* (2017). "Multiple Ways of BES1/BZR1 Degradation to Decode Distinct Developmental and Environmental Cues in Plants." Mol Plant. 10(7):915-917. PMID: 28629641 Yang, M., Li, C., Cai, Z., Hu, Y., Nolan, T., Yu, F., Xie, Q., Tang, G. and Wang, X.* (2017). "SINAT E3 Ligases Control the Light-Mediated Stability of the Brassinosteroid-Activated Transcription Factor BES1 in Arabidopsis." Dev Cell. 41(1): 47-58 e44. PMID: 28399399 Qiao, S., Sun, S., Wang, L., Wu. Z., Li, C., Li, X., Wang, T., Leng, L., Tian, W., Lu, T. and Wang, X*. (2017). "The RLA1/SMOS1 Transcriptio n Factor Functions with OsBZR1 to Regulate Brassinosteroid Signaling and Rice Architecture." Plant Cell. 29(2):292-309. PMID: 28100707 Wang, D., Yang, C., Wang, H., Wu, Z., Jiang, J., Liu, J., He, Z., Chang, F., Ma, H. and Wang, X*. (2016). "BKI1 regulates plant architecture through coordinated inhibition of the brassinosteroid and ERECTA signaling pathways in Arabidopsis." Mol Plant. 10(2):297-308. PMID: 27988365 Hao, Y., Wang, H., Qiao, S., Leng, L. and Wang, X*. (2016). "Histone deacetylase HDA6 enhances brassinosteroid signaling by inhibiting the BIN2 kinase." Proc Natl Acad Sci U S A. 113(37):10418-23. PMID: 27562168 Sun, S., Chen, D., Li, X., Qiao, S., Shi, C., Li, C., Shen, H. and Wang, X.* (2015). “Brassinosteroid Signaling Regulates Leaf Erectness in Oryza sativa via the Control of a Specific U-Type Cyclin and Cell Proliferation.” Dev Cell. 34(2):220-8. PMID：26190148 Jiang, J., Zhang, C., and Wang, X.* (2015). “A Recently Evolved Isoform of the Transcription Factor BES1 Promotes Brassinosteroid Signaling and Development in Arabidopsis thaliana.” Plant Cell. 27(2):361-74. PMID: 25649439 Jiang, J., Wang, T., Wu, Z., Wang, J., Zhang, C., Wang, H., Wang, Z. and Wang, X.* (2015). “The Intrinsically Disordered Protein BKI1 Is Essential for Inhibiting BRI1 Signaling in Plants.” Mol Plant. 8, 1675-1678. PMID: 26296798 Cheng, Y., Zhu, W., Chen, Y., Ito, S., Asami, T. and Wang, X.* (2014). “Brassinosteroids control root epidermal cell fate via direct regulation of a MYB-bHLH-WD40 complex by GSK3-like kinases.” Elife. PMID: 24771765 Yang, C., Liu, J., Dong, X., Cai, Z., Tian, W. and Wang, X.* (2014). “Short-term and continuing stresses differentially interplay with multiple hormones to regulate plant survival and growth.” Mol Plant. 7, 841-855. PMID: 24499771 Wang, J., Jiang, J., Wang, J., Chen, L., Fan, S., Wu, J., Wang, X. and Wang, Z. (2014). “Structural insights into the negative regulation of BRI1 signaling by BRI1-interacting protein BKI1.” Cell Res. 24, 1328-1341. PMID: 25331450 Cai, Z., Liu, J., Wang, H., Yang, C., Chen, Y., Li, Y., Pan, S., Dong, R., Tang, G., Barajas-Lopez Jde, D., Fujii, H. and Wang, X.* (2014). “GSK3-like kinases positively modulate abscisic acid signaling through phosphorylating subgroup III SnRK2s in Arabidopsis.” Proc Natl Acad Sci USA. 111, 9651-9656. PMID：24928519 Zhu, W., Wang, H., Fujioka, S., Zhou, T., Tian, H., Tian, W. and Wang, X.* (2013). “Homeostasis of brassinosteroids regulated by DRL1, a putative acyltransferase in Arabidopsis.” Mol Plant. 6, 546-558. PMID: 23204503 Wang, Y., Sun, S., Zhu, W., Jia, K., Yang, H. and Wang, X.* (2013). “Strigolactone/MAX2-induced degradation of brassinosteroid transcriptional effector BES1 regulates shoot branching.” Dev Cell. 27, 681-688. PMID：24369836 Yang, C., Zhang, C., Lu, Y., Jin, J., and Wang, X.* (2011). “The mechanisms of brassinosteroids' action: from signal transduction to plant development.” Mol Plant. 4, 588-600. PMID: 21471332 Wang, H., Yang, C., Zhang, C., Wang, N., Lu, D., Wang, J., Zhang, S., Wang, Z., Ma, H., and Wang, X.* (2011). “Dual role of BKI1 and 14-3-3 s in brassinosteroid signaling to link receptor with transcription factors.” Dev Cell. 21, 825-834. PMID: 22075146 Ye, Q., Zhu, W., Li, L., Zhang, S., Yin, Y., Ma, H. and Wang, X.* (2010). “Brassinosteroids control male fertility by regulating the expression of key genes involved in Arabidopsis anther and pollen development.” Proc Natl Acad Sci USA. 107, 6100-6105. PMID: 20231470 Zhang, S., Cai, Z. and Wang, X.* (2009). “The primary signaling outputs of brassinosteroids are regulated by abscisic acid signaling.” Proc Natl Acad Sci USA. 106, 4543-4548. PMID: 19240210 Wang, X., Kong, H. and Ma, H. (2009). “F-box proteins regulate ethylene signaling and more.” Genes Dev. 23, 391-396. PMID: 19240128 Wang, X. and Chory, J. (2006). “Brassinosteroids regulate dissociation of BKI1, a negative regulator of BRI1 signaling, from the plasma membrane.” Science. 313, 1118-1122. PMID: 16857903 Wang, X., Li, X., Meisenhelder, J., Hunter, T., Yoshida, S., Asami, T. and Chory, J. (2005). “Autoregulation and homodimerization are involved in the activation of the plant steroid receptor BRI1.” Dev Cell. 8, 855-865. PMID: 15935775 宋纯鹏，王学路.《植物生理学》（主译）科学出版社，第四版（2009）和第五版（2015）北京ISBN 978-7-03-025169-5。