Tosi, Sabrina - Brunel University - Department of Life Sciences, Biomedical Sciences

个人简介

Dr Sabrina Tosi graduated in Biological Sciences at the University of Milan (Italy) in 1989 and then attained her post-graduate degree in Human Cytogenetics at the University of Pavia (Italy) in 1992. Between 1989 and 1993 she was a research scientist at the Department of Paediatric Haematology, University of Milan, Ospedale San Gerardo, Monza (Italy). During this time she worked also as a visiting research scientist at Oncogenetic Laboratory, Children's Hospital, University of Giessen (Germany) for approximately a year. In 1994, Dr Tosi transferred to the University of Oxford to work as a research scientist, she then enrolled and completed her DPhil studies in 1999. She continued to work at the University of Oxford until July 2005, when she was appointed as Lecturer in Biosciences at Brunel University London.

研究领域

Dr Sabrina Tosi is the Head of the Leukaemia and Chromosome Research Laboratory. Her research focuses on the contribution of chromosomal abnormalities to leukaemia. Dr Tosi has a particular interest towards the study of childhood leukaemia. This interest dates back to 1989, when she started her scientific career soon after her undergraduate studies. The main methodological approach used in the laboratory involves the application of modern molecular cytogenetic techniques to unravel the genetic changes at the basis of leukaemic transformation. The projects currently ongoing in the lab are based on the use of fluorescence in situ hybridisation (FISH) and array-comparative genomic hybridisation. These methods have enabled the characterization of new non-random chromosomal translocations specifically associated with certain leukaemia subtypes. More recently, Dr Tosi’s research interests have extended to view chromosomal alterations in context with the higher order chromatin organisation and expression patterns.

近期论文

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Owoka, T. , Vetter, M. , Federico, C. , Saccone, S. and Tosi, S. (2015) 'Detection of t(7;12)(q36;p13) in paediatric leukaemia using dual colour fluorescence in situ hybridisation'. Hematology and Leukemia, 3 doi: 10.7243/2052-434X-3-4 Download publication Tosi, S. , Mostafa Kamel, Y. , Owoka, T. , Federico, C. , et al. (2015) 'Paediatric acute myeloid leukaemia with the t(7;12)(q36;p13) rearrangement: a review of the biological and clinical management aspects'. Biomarker Research, 3 (1). doi: 10.1186/s40364-015-0041-4 Download publication Kamel, YM. , Naiel, A. , Alshehri, A. , Saccone, S. , et al. (2014) 'Fluorescence in situ hybridisation assays designed for del(7q) detection uncover more complex rearrangements in myeloid leukaemia cell lines'. Trends in Cancer Research, 10 pp. 17 - 26. Download publication Leotta, CG. , Federico, C. , Brundo, MV. , Tosi, S. and Saccone, S. (2014) 'HLXB9 gene expression, and nuclear location during in vitro neuronal differentiation in the SK-N-BE neuroblastoma cell line'. PLoS One, 9 (8). doi: 10.1371/journal.pone.0105481 Download publication Naiel, A. , Vetter, M. , Plekhanova, O. , Fleischman, E. , et al. (2013) 'A novel three-colour fluorescence in situ hybridization approach for the detection of t(7;12)(q36;p13) in acute myeloid leukaemia reveals new cryptic three way translocation t(7;12;16)'. Cancers, 5 (1). pp. 281 - 295. doi: 10.3390/cancers5010281 Download publication Ballabio, E. , Regan, R. , Garimberti, E. , Harbott, J. , et al. (2011) 'Genomic imbalances are confined to non-proliferating cells in paediatric patients with acute myeloid leukaemia and a normal or incomplete karyotype'. PLoS ONE, 6 (6). doi: 10.1371/journal.pone.0020607 Download publication Lake, A. , Shield, LA. , Cordano, P. , Chui, DT. , et al. (2009) 'Mutations of NFKBA, encoding IkappaBalpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases'. Anticancer Research: international journal of cancer research and treatment, 125 (6). pp. 1334 - 1342. doi: 10.1002/ijc.24502 Download publication Ballabio, E. , Cantarella, CD. , Federico, C. , Di Mare, P. , et al. (2009) 'Ectopic expression of the HLXB9 gene is associated with an altered nuclear position in t(7;12) leukaemias'. Leukemia, 23 pp. 1179 - 1182. doi: 10.1038/leu.2009.15 Download publication Federico, C. , Cantarella, CD. , Di Mare, P. , Tosi, S. and Saccone, S. (2008) 'The radial arrangement of the human chromosome 7 in the lymphocyte nucleus is associated with chromosomal band gene density'. Chromosoma: Biology of the Nucleus, 117 (4). pp. 399 - 410. doi: 10.1007/s00412-008-0160-x Download publication Hauer, J. , Tosi, S. , Schuster, FR. , Harbott, J. , et al. (2008) 'Graft versus leukaemia effect after haploidentical HSCT in a MLL-negative infant AML with HLXB9/ETV6 rearrangement'. Pediatr Blood Cancer, 50 pp. 921 - 923. Tosi, S. , Ballabio, E. , Teigler-Schlegel, A. , Boultwood, J. , et al. (2005) 'Characterization of 6q abnormalities in childhood acute myeloid leukemia and identification of a novel t(6;11)(q24.1;p15.5) resulting in a NUP98-C6orf80 fusion in a case of acute megakaryoblastic leukemia'. Genes Chromosomes and Cancer, 44 (3). pp. 225 - 232. doi: 10.1002/gcc.20233 Tosi, S. , Hughes, J. , Scherer, SW. , Nakabayashi, K. , et al. (2003) 'Heterogeneity of the 7q36 breakpoints in the t(7;12) involving ETV6 in infant leukemia'. GENES CHROMOSOMES & CANCER, 38 (2). pp. 191 - 200. doi: 10.1002/gcc.10258 Scherer, SW. , Cheung, J. , MacDonald, JR. , Osborne, LR. , et al. (2003) 'Human chromosome 7: DNA sequence and biology'. Science, 300 (5620). pp. 767 - 772. doi: 10.1126/science.1083423 Fernando, FS. , Conforti, L. , Tosi, S. , Smith, AD. and Coleman, MP. (2002) 'Human homologue of a gene mutated in the slow Wallerian degeneration (C57BL/Wld(s)) mouse'. GENE, 284 (1-2). pp. 23 - 29. doi: 10.1016/S0378-1119(02)00394-3 Boultwood, J. , Fidler, C. , Strickson, AJ. , Watkins, F. , et al. (2002) 'Narrowing and genomic annotation of the commonly deleted region of the 5q- syndrome'. Blood, 99 (12). pp. 4638 - 4641. doi: 10.1182/blood.V99.12.4638 Minelli, A. , Maserati, E. , Giudici, G. , Tosi, S. , et al. (2001) 'Familial partial monosomy 7 and myelodysplasia: different parental origin of the monosomy 7 suggests action of a mutator gene'. CANCER GENETICS AND CYTOGENETICS, 124 (2). pp. 147 - 151. doi: 10.1016/S0165-4608(00)00344-7 Cazzaniga, G. , Daniotti, M. , Tosi, S. , Giudici, G. , et al. (2001) 'The paired box domain gene PAX5 is fused to ETV6/TEL in an acute lymphoblastic leukemia case'. Cancer Research, 61 (12). pp. 4666 - 4670. Tosi, S. , Harbott, J. , Teigler-Schlegel, A. , Haas, OA. , et al. (2000) 't(7;12)(q36;p13), a new recurrent translocation involving ETV6 in infant leukemia'. GENES CHROMOSOMES & CANCER, 29 (4). pp. 325 - 332. doi: 10.1002/1098-2264(2000)9999:9999<::AID-GCC1039>3.0.CO;2-9 Cazzaniga, G. , Tosi, S. , Aloisi, A. , Giudici, G. , et al. (1999) 'The tyrosine kinase Abl-related gene ARG is fused to ETV6 in an AML-M4Eo patient with a t(1;12)(q25;p13): Molecular cloning of both reciprocal transcripts'. BLOOD, 94 (12). pp. 4370 - 4373. Tosi, S. , Scherer, SW. , Giudici, G. , Rambaldi, A. , et al. (1999) 'Delineation of multiple deleted regions in 7q in myeloid disorders.'. Genes Chromosomes Cancer, 25 (4). pp. 384 - 392.