Rand-Weaver, Mariann - Brunel University - Department of Life Sciences, Biomedical Sciences

个人简介

PhD Biochemistry 1986 - King’s College (KQC), London (awarded Tadion-Rideal Prize for distinguished post-graduate work) BSc Biochemistry 1982 - First Class Honours King’s College (KQC), London.

研究领域

I am currently involved in research council/industry-funded projects aimed at evaluating the mode of action of environmental chemicals and pharmaceuticals, and their impact on aquatic organisms. Studies at the genetic, protein and physiological levels are conducted. Building on my interest and expertise in endocrinology, I am developing a more health-related focus and have recently become involved in investigating the underlying mechanisms of drug resistance in hormone-dependent breast cancer, and the endocrine actions of phytoestrogens

近期论文

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Rand-Weaver, M. , Patel, A. , Margiotta-Casaluci, L. , Sumpter, JP. , et al. (2013) 'The read-across hypothesis and environmental risk assessment of pharmaceuticals'. Environmental Science and Technology, 47 (20). pp. 11384 - 11395. doi: 10.1021/es402065a Download publication Bannister, R. , Beresford, N. , Granger, DW. , Pounds, NA. , et al. (2013) 'No substantial changes in estrogen receptor and estrogen-related receptor orthologue gene transcription in Marisa cornuarietis exposed to estrogenic chemicals'. Aquatic Toxicology, 140-141 pp. 19 - 26. doi: 10.1016/j.aquatox.2013.05.002 Download publication Zachariades, E. , Mparmpakas, D. , Thomas, P. , Rand-Weaver, M. and Karteris, E. (2012) 'Crucial cross-talk of interleukin-1β and progesterone in human choriocarcinoma'. International Journal of Oncology, 40 (5). pp. 1358 - 1364. doi: 10.3892/ijo.2012.1349 Download publication Zachariades, E. , Mparmpakas, D. , Pang, Y. , Rand-Weaver, M. , et al. (2012) 'Changes in placental progesterone receptors in term and preterm labour'. Placenta, 33 (5). pp. 367 - 372. doi: 10.1016/j.placenta.2012.01.002 Giltrow, E. , Eccles, PD. , Hutchinson, TH. , Sumpter, JP. and Rand-Weaver, M. (2011) 'Characterisation and expression of β1-, β2- and β3-adrenergic receptors in the fathead minnow (Pimephales promelas)'. General and Comparative Endocrinology, 173 (3). pp. 483 - 490. doi: 10.1016/j.ygcen.2011.07.006 Download publication Zachariades, E. , Foster, H. , Goumenou, A. , Thomas, P. , et al. (2011) 'Expression of membrane and nuclear progesterone receptors in two human placental choriocarcinoma cell lines (JEG-3 and BeWo): Effects of syncytialization'. International Journal of Molecular Medicine, 27 (6). pp. 767 - 774. doi: 10.3892/ijmm.2011.657 Download publication Giltrow, E. , Eccles, PD. , Winter, MJ. , McCormack, PJ. , et al. (2009) 'Chronic effects assessment and plasma concentrations of the β-blocker propranolol in fathead minnows (Pimephales promelas)'. Aquatic Toxicology, 95 (3). pp. 195 - 202. doi: 10.1016/j.aquatox.2009.09.002 Download publication Rand-Weaver, M. , Bannister, R. , Beresford, N. , May, D. and Routledge, EJ. (2007) 'Novel estrogen receptor-related transcripts in Marisa cornuarietis: A freshwater snail with reported sensitivity to estrogenic chemicals'. Environmental Science and Technology, 41 (7). pp. 2643 - 2650. doi: 10.1021/es062565m Schulte-Oehlmann, U. , Albanis, T. , Allera, A. , Bachmann, J. , et al. (2006) 'COMPRENDO: Focus and approach'. Environmental Health Perspectives, 114 (Supplement 1). pp. 98 - 100. doi: 10.1289/ehp.8060 Download publication Halm, S. , Kwon, JY. , Rand-Weaver, M. , Sumpter, JP. , et al. (2003) 'Cloning and gene expression of P450 17α-hydroxylase, 17,20-lyase cDNA in the gonads and brain of the fathead minnow Pimephales promelas'. General and Comparative Endocrinology, 130 (3). pp. 256 - 266. doi: 10.1016/S0016-6480(02)00592-0 Pottinger, TG. , Rand-Weaver, N. and Sumpter, JP. (2003) 'Overwinter fasting and re-feeding in rainbow trout: Plasma growth hormone and cortisol levels in relation to energy mobilisation'. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 136 (3). pp. 403 - 417. doi: 10.1016/S1096-4959(03)00212-4 Swanson, P. , Dickey, JT. , Rand-Weaver, M. and Millar, RP. (2002) 'Cloning, partial cDNA sequence, and expression of two gonadotropin-releasing hormone receptors in coho salmon'. Biology of Reproduction, 66 pp. 202 - 202. Halm, S. , Pounds, N. , Maddix, S. , Rand-Weaver, M. , et al. (2002) 'Exposure to exogenous 17β-oestradiol disrupts P450aromB mRNA expression in the brain and gonad of adult fathead minnows (Pimephales promelas)'. Aquatic Toxicology, 60 (3-4). pp. 285 - 299. doi: 10.1016/S0166-445X(02)00011-5 Santos, EM. , Rand-Weaver, M. and Tyler, CR. (2001) 'Follicle-stimulating hormone and its alpha and beta subunits in rainbow trout (Oncorhynchus mykiss): Purification, characterization, development of specific radioimmunoassays, and their seasonal plasma and pituitary concentrations in females'. Biology of Reproduction, 65 (1). pp. 288 - 294. doi: 10.1095/biolreprod65.1.288 Wickens, A. , May, D. and Rand-Weaver, M. (2001) 'Molecular characterisation of a putative Atlantic salmon (Salmo salar) odorant receptor'. Comparative Biochemistry and Physiology B-Biochemistry and Molecular Biology, 129 (2-3). pp. 653 - 660. doi: 10.1016/S1096-4959(01)00364-5 Halm, S. , Rand-Weaver, M. , Sumpter, JP. and Tyler, CR. (2001) 'Cloning and molecular characterization of an ovarian-derived (brain-like) P450 aromatase cDNA and development of a competitive RT-PCR assay to quantify its expression in the fathead minnow (pimephales promelas)'. Fish Physiology and Biochemistry, 24 (1). pp. 49 - 62. doi: 10.1023/A:1011162920955 RAND-WEAVER. , May, Denise. and Wickens, Andrew. (2001) 'Molecular characterisation of a putative Atlantic salmon (Salmo salar) odorant receptor'. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 129 (2-3). pp. 653 - 660. doi: 10.1016/S1096-4959(01)00364-5 Bhaskaran, A. , May, D. , Rand-Weaver, M. and Tyler, CR. (2000) 'Molecular characterization of the first non-mammalian p73 cDNA'. Comparative Biochemistry and Physiology - Part B: Biochemistry and Molecular Biology, 126 (1). pp. 49 - 57. doi: 10.1016/S0305-0491(00)00174-7 Bhaskaran, A. , May, D. , Rand-Weaver, M. and Tyler, CR. (1999) 'Fish p53 as a possible biomarker for genotoxins in the aquatic environment'. Environmental and Molecular Mutagenesis, 33 (3). pp. 177 - 184. May, D. , Alrubaian, J. , Patel, S. , Dores, RM. and Rand-Weaver, M. (1999) 'Studies on the GH/SL gene family: cloning of African lungfish (Protopterus annectens) growth hormone and somatolactin and toad (Bufo marinus) growth hormone'. General and Comparative Endocrinology, 113 (1). pp. 121 - 135. doi: 10.1006/gcen.1998.7185