Pathan, Ansar - Brunel University - Department of Life Sciences, Biomedical Sciences

研究领域

Innate and adaptive immunity Host-pathogen interaction Immunity to Mycobacterium tuberculosis TB diagnostics Vaccinology

近期论文

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Rowland, R. , Pathan, AA. , Satti, I. , Poulton, ID. , et al. (2013) 'Safety and immunogenicity of an FP9-vectored candidate tuberculosis vaccine (FP85A), alone and with candidate vaccine MVA85A in BCG-vaccinated healthy adults: A phase i clinical trial'. Human Vaccines and Immunotherapeutics, 9 (1). pp. 50 - 62. doi: 10.4161/hv.22464 Pathan, AA. , Minassian, AM. , Sander, CR. , Rowland, R. , et al. (2012) 'Effect of vaccine dose on the safety and immunogenicity of a candidate TB vaccine, MVA85A, in BCG vaccinated UK adults'. Vaccine. Rowland, R. , Brittain, N. , Poulton, ID. , Minassian, AM. , et al. (2012) 'A review of the tolerability of the candidate TB vaccine, MVA85A compared with BCG and Yellow Fever vaccines, and correlation between MVA85A vaccine reactogenicity and cellular immunogenicity'. Trials in Vaccinology, 1 pp. 27 - 35. doi: 10.1016/j.trivac.2012.07.001 Download publication Beveridge, NER. , Price, DA. , Casazza, JP. , Pathan, AA. , et al. (2011) 'Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4(+) memory T lymphocyte populations (vol 37, pg 3089, 2007)'. EUROPEAN JOURNAL OF IMMUNOLOGY, 41 (5). pp. 1501 - 1501. doi: 10.1002/eji.201190032 Minassian, AM. , Rowland, R. , Beveridge, NE. , Poulton, ID. , et al. (2011) 'A Phase I study evaluating the safety and immunogenicity of MVA85A, a candidate TB vaccine, in HIV-infected adults'. BMJ Open, 1 (2). pp. e000223 - e000223. doi: 10.1136/bmjopen-2011-000223 Download publication Griffiths, KL. , Pathan, AA. , Minassian, AM. , Sander, CR. , et al. (2011) 'Th1/Th17 Cell Induction and Corresponding Reduction in ATP Consumption following Vaccination with the Novel Mycobacterium tuberculosis Vaccine MVA85A'. PLoS One, 6 (8). pp. . doi: 10.1371/journal.pone.0023463 Download publication de Cassan, SC. , Pathan, AA. , Sander, CR. , Minassian, A. , et al. (2010) 'Investigating the Induction of Vaccine-Induced Th17 and Regulatory T Cells in Healthy, Mycobacterium bovis BCG-Immunized Adults Vaccinated with a New Tuberculosis Vaccine, MVA85A'. CLINICAL AND VACCINE IMMUNOLOGY, 17 (7). pp. 1066 - 1073. doi: 10.1128/CVI.00047-10 Behboudi, S. , Alisa, A. , Boswell, S. , Anastassiou, J. , et al. (2010) 'Expansion of anti-AFP Th1 and Tc1 responses in hepatocellular carcinoma occur in different stages of disease.'. British Journal of Cancer, 102 (4). pp. 748 - 753. doi: 10.1038/sj.bjc.6605526 Download publication Todryk, SM. , Pathan, AA. , Keating, S. , Porter, DW. , et al. (2009) 'The relationship between human effector and memory T cells measured by ex vivo and cultured ELISPOT following recent and distal priming'. IMMUNOLOGY, 128 (1). pp. 83 - 91. doi: 10.1111/j.1365-2567.2009.03073.x Sander, CR. , Pathan, AA. , Beveridge, NE. , Poulton, I. , et al. (2009) 'Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in mycobacterium tuberculosis-infected individuals'. American Journal of Respiratory and Critical Care Medicine, 179 (8). pp. 724 - 733. doi: 10.1164/rccm.200809-1486OC Download publication Smith, SG. , Joosten, SA. , Verscheure, V. , Pathan, AA. , et al. (2009) 'Identification of major factors influencing ELISpot-based monitoring of cellular responses to antigens from Mycobacterium tuberculosis.'. PLoS One, 4 (11). pp. e7972 - e7972. doi: 10.1371/journal.pone.0007972 Download publication Whelan, KT. , Pathan, AA. , Sander, CR. , Fletcher, HA. , et al. (2009) 'Safety and immunogenicity of boosting BCG vaccinated subjects with BCG: comparison with boosting with a new TB vaccine, MVA85A.'. PLoS One, 4 (6). pp. e5934 - e5934. doi: 10.1371/journal.pone.0005934 Download publication Beveridge, NER. , Fletcher, HA. , Hughes, J. , Pathan, AA. , et al. (2008) 'A comparison of IFN gamma detection methods used in tuberculosis vaccine trials'. TUBERCULOSIS, 88 (6). pp. 631 - 640. doi: 10.1016/j.tube.2008.06.005 Fletcher, HA. , Pathan, AA. , Berthoud, TK. , Dunachie, SJ. , et al. (2008) 'Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta 1'. VACCINE, 26 (41). pp. 5269 - 5275. doi: 10.1016/j.vaccine.2008.07.040 Alisa, A. , Boswell, S. , Pathan, AA. , Ayaru, L. , et al. (2008) 'Human CD4(+) T cells recognize an epitope within alpha-fetoprotein sequence and develop into TGF-beta-producing CD4(+) T cells'. JOURNAL OF IMMUNOLOGY, 180 (7). pp. 5109 - 5117. Beveridge, NER. , Price, DA. , Casazza, JP. , Pathan, AA. , et al. (2007) 'Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4 + memory T lymphocyte populations'. European Journal of Immunology, 37 (11). pp. 3089 - 3100. doi: 10.1002/eji.200737504 Pathan, AA. , Sander, CR. , Fletcher, HA. , Poulton, I. , et al. (2007) 'Boosting BCG with recombinant modified vaccinia ankara expressing antigen 85A: Different boosting intervals and implications for efficacy trials'. PLoS ONE, 2 (10). doi: 10.1371/journal.pone.0001052 Download publication Ayaru, L. , Pereira, SP. , Alisa, A. , Pathan, AA. , et al. (2007) 'Unmasking of alpha-fetoprotein-specific CD4(+) T cell responses in hepatocellular carcinoma patients undergoing embolization'. JOURNAL OF IMMUNOLOGY, 178 (3). pp. 1914 - 1922. Gilbert, SC. , Moorthy, VS. , Andrews, L. , Pathan, AA. , et al. (2006) 'Synergistic DNA-MVA prime-boost vaccination regimes for malaria and tuberculosis'. VACCINE, 24 (21). pp. 4554 - 4561. doi: 10.1016/j.vaccine.2005.08.048 Alisa, A. , Ives, A. , Pathan, AA. , Navarrete, CV. , et al. (2005) 'Analysis of CD4(+) T-cell responses to a novel alpha-fetoprotein-derived epitope in hepatocellular carcinoma patients'. CLINICAL CANCER RESEARCH, 11 (18). pp. 6686 - 6694. doi: 10.1158/1078-0432.CCR-05-0382