Parris, Chris - Brunel University - Department of Life Sciences, Biomedical Sciences

个人简介

2001 - date: Senior Lecturer, Division of Biosciences, School of Health Sciences and Social Care, Brunel University London 1997 - 2001: Lecturer, Dept. Biological Sciences, Brunel University London 1996 - 1997:Post Doc: Dept. Biological Sciences, Brunel University London, Identification of human tumour suppressor genes 1993 - 1996: Post Doc. Lawrence Livermore National Laboratory, Biology and Biotechnology Research Program, California, . Isolation of Human DNA repair genes. 1989 - 1993: Post Doc. National Cancer Institute, NIH, Bethesda, Maryland . . DNA repair and Mutagenesis. Lab of Molecular Carcinogenesis 1985 - 1989: Research Assistant / PhD student (part - time) University College London, UK 1983 - 1985: Research Technician Institute of Urology and Nephrology, University College London, UK

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Wilhelm, EN. , González - Alonso, J. , Parris, C. and Rakobowchuk, M. (2016) 'Exercise intensity modulates the appearance of circulating microvesicles with pro-angiogenic potential upon endothelial cells.'. Am J Physiol Heart Circ Physiol. pp. ajpheart.00516.2016 - ajpheart.00516.2016. doi: 10.1152/ajpheart.00516.2016 Download publication Parris, CN. , Zahir, SA. , Al-Ali, H. , Bourton, EC. , et al. (2015) 'Enhanced γ-H2AX DNA damage foci detection using multimagnification and extended depth of field in imaging flow cytometry'. Cytometry Part A. doi: 10.1002/cyto.a.22697 Download publication Bourton, EC. , Hussain, H. , Plowman, PN. , Harvey, AJ. and Parris, C. (2015) 'Radiosensitivity of Human Breast Cancer Cell Lines Expressing the Breast Tumor Kinase (Brk)'. Journal of Cancer Science and Therapy, 7 (3). pp. 95 - 101. doi: 10.4172/1948-5956.1000331 Download publication Zahir, SA. , Plowman, PN. , Bourton, EC. , Sharif, F. and Parris, C. (2015) 'Increased gamma-H2AX and Rad51 DNA Repair Biomarker Expression in Human Cell Lines Resistant to the Chemotherapeutic Agents Nitrogen Mustard and Cisplatin.'. Chemotherapy, 60 (5). pp. 310 - 320. doi: 10.1159/000430086 Download publication Bourton, EC. , Foster, HA. , Plowman, PN. , Harvey, AJ. and Parris, CN. (2013) 'Hypersensitivity of BRCA1 Heterozygote Lymphoblastoid Cells to Gamma Radiation and PARP Inhibitors.'. J.Genet Syndr Gene Ther, 4 (5). Download publication Bourton, EC. , Plowman, PN. , Harvey, AJ. , Adam Zahir, S. and Parris, CN. (2013) 'The PARP-1 inhibitor Olaparib causes retention of γ-H2AX foci in BRCA1 heterozygote cells following exposure to gamma radiation'. Journal of Cancer Therapy, 4 (11a). pp. 44 - 52. doi: 10.4236/jct.2013.411A006 Download publication Ulus-Senguloglu, G. , Arlett, CF. , Plowman, PN. , Parnell, J. , et al. (2012) 'Elevated expression of artemis in human fibroblast cells is associated with cellular radiosensitivity and increased apoptosis'. British Journal of Cancer, 107 (9). pp. 1506 - 1513. doi: 10.1038/bjc.2012.443 Download publication Parris, CN. , Bourton, EC. and Plowman, PN. (2012) 'Multispectral imaging flow cytometry reveals distinct frequencies of gamma-H2AX foci induction in DNA double strand break repair defective human cells lines'. MUTAGENESIS, 27 (1). pp. 132 - 132. Bourton, EC. , Plowman, PN. , Zahir, SA. , Senguloglu, GU. , et al. (2012) 'Multispectral imaging flow cytometry reveals distinct frequencies of γ-H2AX foci induction in DNA double strand break repair defective human cell lines.'. Cytometry A, 81 (2). pp. 130 - 137. doi: 10.1002/cyto.a.21171 Bourton, EC. , Plowman, PN. and Parris, CN. (2012) 'Prolonged expression of the gamma-H2AX DNA repair biomarker correlates with excess acute and chronic toxicity from radiotherapy treatment'. MUTAGENESIS, 27 (1). pp. 109 - 109. Bourton, EC. , Plowman, PN. , Smith, D. , Arlett, CF. and Parris, CN. (2011) 'Prolonged expression of the γ-H2AX DNA repair biomarker correlates with excess acute and chronic toxicity from radiotherapy treatment'. International Journal of Cancer, 129 (12). pp. 2928 - 2934. doi: 10.1002/ijc.25953 Download publication Abbaszadeh, F. , Clingen, PH. , Arlett, CF. , Plowman, PN. , et al. (2010) 'A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitivity in a patient with xeroderma pigmentosum'. Journal of Medical Genetics, 47 (3). pp. 176 - 181. doi: 10.1136/jmg.2009.068866 Abbaszadeh, F. , Clingen, PH. , Arlett, C. , Plowman, PN. , et al. (2010) 'A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitvity in a xeroderma pigmentosum patient'. Journal of Medical Genetics, 46 (11). pp. 1 - 24. doi: 10.1136/jmg.2009.068866 Download publication Parris, C. , Arlett, CF. , Clingen, PH. and Hartley, JA. (2007) 'Chemosensitivity of primary human fibroblasts with defective unhooking of DNA interstrand cross-links'. Experimental Cell Research, 313 (4). pp. 753 - 760. doi: 10.1016/j.yexcr.2006.11.007 Parris, C. , Abbaszadeh, F. , Arlett, CF. and Plowman, PN. (2006) 'Clinical and cellular ionizing radiation sensitivity in a patient with xeroderma pigmentosum'. British Journal of Radiology, 79 (942). pp. 510 - 517. doi: 10.1259/bjr/83726649 Boyle, J. , Kill, IR. and Parris, CN. (2005) 'Heterogeneity of dimer excision in young and senescent human dermal fibroblasts'. Aging Cell, 4 (5). pp. 247 - 255. doi: 10.1111/j.1474-9726.2005.00167.x Meaburn, KJ. , Parris, CN. and Bridger, JM. (2005) 'The manipulation of chromosomes by mankind: The uses of microcell-mediated chromosome transfer'. Chromosoma, 114 (4). pp. 263 - 274. doi: 10.1007/s00412-005-0014-8 Wilding, J. , Meijne, E. , Haines, J. , Moody, J. , et al. (2002) 'Functional evidence from microcell-mediated chromosome transfer of myeloid leukemia suppressor genes on human chromosomes 7 and 11'. Genes, Chromosomes and Cancer, 34 (4). pp. 390 - 397. doi: 10.1002/gcc.10086 Mokbel, K. , Ghilchik, M. , Williams, G. , Akbar, N. , et al. (2000) 'The association between telomerase activity and hormone receptor status and p53 expression in breast cancer.'. International journal of surgical investigation, 1 (6). pp. 509 - 516.