研究领域
Mechanisms underlying therapeutic effects of exogenous recombinant surfactant protein D (SP-D) in disease models of pulmonary hypersensitivity, inflammation and infection
Host pathogen interaction studies using models such as Aspergillus fumigates, Mycobacterium tuberculosis, malaria parasite and Schistosomes.
In vivo modulation of dendritic cell functions and mechanism of helper T cell polarisation by SP-D
Mechanisms governing SP-D mediated survival and induction of apoptosis of eosinophils and macrophages
Instructive role of collectins and complement proteins in dendritic cell-mediated handling of apoptotic cells
Structure-function studies on complement protein C1q and novel members of C1q/TNF super family
Generation of recombinant inhibitors of classical complement pathway
Role of complement in Alzheimer’s disease and familial dementia
Immunological nature of fetal-maternal interaction; involvement of surfactant proteins in parturition, pre-term birth, preeclampsia, miscarriage and intrauterine growth retardation
Innate immune aspects of cancer
Identification, cloning, characterisation and tolerisation of pathogenic T cells in autoimmunity using MHC class II (HLA-DR) multimer technology
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Radanova, M. , Vasilev, V. , Deliyska, B. , Kishore, U. , et al. (2011) 'Anti-C1q autoantibodies specific against the globular domain of the C1qB-chain from patient with lupus nephritis inhibit C1q binding to IgG and CRP'. Immunobiology. doi: 10.1016/j.imbio.2011.11.007
Kishore, U. and Sim, RB. (2012) 'Factor H as a regulator of the classical pathway activation'. Immunobiology, 217 (2). pp. 162 - 168. doi: 10.1016/j.imbio.2011.07.024
Kang, YH. , Urban, BC. , Sim, RB. and Kishore, U. (2012) 'Human complement Factor H modulates C1q-mediated phagocytosis of apoptotic cells.'. Immunobiology, 217 (4). pp. 455 - 464. doi: 10.1016/j.imbio.2011.10.008
Gupta, A. , Kaul, A. , Tsolaki, AG. , Kishore, U. and Bhakta, S. (2012) 'Mycobacterium tuberculosis: Immune evasion, latency and reactivation'. Immunobiology, 217 (3). pp. 363 - 374. doi: 10.1016/j.imbio.2011.07.008
Nayak, A. , Pedenekar, L. , Reid, KB. and Kishore, U. (2011) 'Complement and non-complement activating functions of C1q: A prototypical innate immune molecule'. Innate Immunity. doi: 10.1177/1753425910396252
Sudhakaran, C. , Kishore, U. , Anjana, RM. , Unnikrishnan, R. and Mohan, V. (2011) 'Effectiveness of sitagliptin in asian Indian patients with type 2 diabetes-an Indian tertiary diabetes care center experience'. Diabetes Technology & Therapeutics, 13 (1). pp. 27 - 32. doi: 10.1089/dia.2010.0120
Sumner, R. , Parton, A. , Nowicky, AV. , Kishore, U. and Gidron, Y. (2011) 'Hemispheric lateralisation and immune function: A systematic review of human research'. Journal of Neuroimmunology, 240-241 pp. 1 - 12. doi: 10.1016/j.jneuroim.2011.08.017 Download publication
Nayak, A. , Ansar, R. , Verma, SK. , Bonifati, DM. and Kishore, U. (2011) 'Huntington's disease: An immune perspective'. Neurology Research International, 2011 pp. 563784 - 563784. doi: 10.1155/2011/563784 Download publication
Tan, LA. , Yang, AC. , Kishore, U. and Sim, RB. (2011) 'Interactions of complement proteins C1q and factor H with lipid A and Escherichia coli: Further evidence that factor H regulates the classical complement pathway'. Protein Cell, 2 (4). pp. 320 - 332. doi: 10.1007/s13238-011-1029-y
Verma, SK. , Ganesan, TS. , Kishore, U. and Parker, PJ. (2011) 'The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A'. Protein Cell, 2 (3). pp. 237 - 249. doi: 10.1007/s13238-011-1028-z
Tan, LA. , Yu, B. , Sim, FC. , Kishore, U. and Sim, RB. (2010) 'Complement activation by phospholipids: The interplay of factor H and C1q'. Protein & Cell, 1 (11). pp. 1033 - 1049. doi: 10.1007/s13238-010-0125-8
Al-Madani, WA. , Siddiqi, NJ. , Alhomida, AS. , Khan, HA. , et al. (2010) 'Increased urinary excretion of carnitine and acylcarnitine by mercuric chloride is reversed by 2,3-dimercapto-1-propanesulfonic acid in rats'. International Journal of Toxicology, 29 (3). pp. 313 - 317. doi: 10.1177/1091581810364852
Madan, T. , Reid, KB. , Clark, H. , Singh, M. , et al. (2010) 'Susceptibility of mice genetically deficient in SP-A or SP-D gene to invasive pulmonary aspergillosis'. Molecular Immunology, 47 (10). pp. 1923 - 1930. doi: 10.1016/j.molimm.2010.02.027
Nayak, A. , Ferluga, J. , Tsolaki, AG. and Kishore, U. (2010) 'The non-classical functions of the classical complement pathway recognition subcomponent C1q'. Immunology Letters, 131 (2). pp. 139 - 150. doi: 10.1016/j.imlet.2010.03.012
Waters, P. , Vaid, M. , Kishore, U. and Madan, T. (2009) 'Lung surfactant proteins A and D as pattern recognition proteins'. Advances in Experimental Medicine and Biology, 653 pp. 74 - 97. doi: 10.1007/978-1-4419-0901-5_6
Shrive, AK. , Martin, C. , Burns, I. , Paterson, JM. , et al. (2009) 'Structural characterisation of ligand-binding determinants in human lung surfactant protein D: Influence of Asp325'. Journal of Molecular Biology, 394 (4-10). pp. 776 - 788. doi: 10.1016/j.jmb.2009.09.057 Download publication
Kishore, U. (2009) 'Target pattern recognition in innate immunity'. Advances in Experimental Medicine and Biology, 653 pp. ix - x. doi: 10.1007/978-1-4419-0901-5
Singh, M. , Madan, T. , Waters, P. , Sonar, S. , et al. (2009) 'Therapeutic effects of recombinant forms of full-length and truncated human surfactant protein D in a murine model of invasive pulmonary aspergillosis'. Molecular Immunology, 46 (11-12). pp. 2363 - 2369. doi: 10.1016/j.molimm.2009.03.019
Gadjeva, MG. , Rouseva, MM. , Zlatarova, AS. , Reid, KBM. , et al. (2008) 'Interaction of human C1q with IgG and IgM: Revisited'. Biochemistry, 47 (49). pp. 13093 - 13102. doi: 10.1021/bi801131h
Roumenina, LT. , Popov, KT. , Bureeva, SV. , Kojouharova, M. , et al. (2008) 'Interaction of the globular domain of human C1q with Salmonella typhimurium lipopolysaccharide'. Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, 1784 (9). pp. 1271 - 1276. doi: 10.1016/j.bbapap.2008.04.029 Download publication
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