Karteris, Emmanouil - Brunel University - Department of Life Sciences, Biomedical Sciences

个人简介

1995. He then was awarded an MSc with Distinction in Medical Genetics with Immunology from Brunel University London in 1996 and completed his PhD in Molecular Endocrinology from the University of Warwick in 2000. He then undertook post-doctoral appointments at the University of Warwick, including a prestigious VIP Research Fellowship from the Welcome Trust. He was appointed as Lecturer in Endocrinology at the University of Warwick from 2005-2006 and then he transferred to Brunel University London as a Lecturer in Biosciences from 2006 onwards

研究领域

Dr Karteris has a long standing interest in mTOR signalling with emphasis in reproductive endocrinology, ovarian cancer and Alzheimer’s disease. In particular, Dr Karteris is interested in dissecting the role of DEPTOR (an endogenous inhibitor of mTOR complexes) and how it can be modulated by steroids and neurohormones. Dr Karteris has a recognized publication record in receptor biochemistry and cell signalling. Dr Karteris has published 40 research manuscripts, presented over 80 research abstracts in leading national and international conferences. Many of these papers are generating a strong and influential impact not only to the biomedical field (as it is evident from the high citation index) but also to the society as they deal with topical issues such as effects of stress during pregnancy. Moreover Dr Karteris has established collaborations with leading authorities in their fields and has been successful in obtaining research grants at national and international level.

近期论文

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Davies, J. , Chen, J. , Pink, R. , Carter, D. , et al. (2015) 'Orexin receptors exert a neuroprotective effect in Alzheimer's disease (AD) via heterodimerization with GPR103'. Scientific Reports, 5 doi: 10.1038/srep12584 Download publication Zachariades, E. , Foster, H. , Goumenou, A. , Thomas, P. , et al. (2011) 'Expression of membrane and nuclear progesterone receptors in two human placental choriocarcinoma cell lines (JEG-3 and BeWo): Effects of syncytialization'. International Journal of Molecular Medicine, 27 (6). pp. 767 - 774. doi: 10.3892/ijmm.2011.657 Download publication Foster, H. , Coley, HM. , Goumenou, A. , Pados, G. , et al. (2010) 'Differential expression of mTOR signalling components in drug resistance in ovarian cancer'. Anticancer Research, 30 (9). pp. 3529 - 3534. Download publication Patel, VH. , Chen, J. , Ramanjaneya, M. , Karteris, E. , et al. (2010) 'G-protein coupled estrogen receptor 1 expression in rat and human heart: Protective role during ischaemic stress'. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 26 (2). pp. 193 - 199. doi: 10.3892/ijmm_00000452 Karteris, E. , Foster, H. , Karamouti, M. and Goumenou, A. (2010) 'Congenital imperforate hymen with hydrocolpos and hydronephrosis associated with severe hydramnios and increase of maternal ovarian steroidogenic enzymes.'. Journal of Pediatric and Adolescent Gynecology, 23 (3). pp. 136 - 141. doi: 10.1016/j.jpag.2009.10.002 Download publication Mparmpakas, D. , Zachariades, E. , Foster, H. , Kara, A. , et al. (2010) 'Expression of mTOR and downstream signalling components in the JEG-3 and BeWo human placental choriocarcinoma cell lines'. International Journal of Molecular Medicine, 25 (1). pp. 65 - 69. doi: 10.3892/ijmm_00000314 Download publication Foster, H. , Reynolds, A. , Stenbeck, G. , Dong, J. , et al. (2010) 'Internalisation of membrane progesterone receptor-alpha after treatment with progesterone: Potential involvement of a clathrin-dependent pathway'. Molecular Medicine Reports, 3 (1). pp. 27 - 35. doi: 10.3892/mmr_00000214 Download publication Mottershead, M. , Karteris, E. , Barclay, JY. , Suortamo, S. , et al. (2006) 'Immunohistochemical and quantitative mRNA assessment of ghrelin expression in gastric and oesophageal adenocarcinoma'. Journal of Clinical Pathology, 60 (4). pp. 405 - 409. doi: 10.1136/jcp.2006.038356 Chen, J. , Karteris, E. , Collins, D. and Randeva, HS. (2006) 'Differential expression of mouse orexin receptor type-2 (OX2R) variants in the mouse brain'. Brain Research, 1103 (1). pp. 20 - 24. doi: 10.1016/j.brainres.2006.05.054 Karteris, E. , Zervou, S. , Pang, Y. , Dong, J. , et al. (2006) 'Progesterone Signaling in Human Myometrium through Two Novel Membrane G Protein-Coupled Receptors: Potential Role in Functional Progesterone Withdrawal at Term'. Molecular Endocrinology, 20 (7). pp. 1519 - 1534. doi: 10.1210/me.2005-0243 Chen, J. , Tan, B. , Karteris, E. , Zervou, S. , et al. (2006) 'Secretion of adiponectin by human placenta: differential modulation of adiponectin and its receptors by cytokines'. Diabetologia, 49 (6). pp. 1292 - 1302. doi: 10.1007/s00125-006-0194-7 Karteris, E. , Vatish, M. , Hillhouse, EW. and Grammatopoulos, DK. (2005) 'Preeclampsia is associated with impaired regulation of the placental nitric oxide-cyclic guanosine monophosphate pathway by corticotropin-releasing hormone (CRH) and CRH-related peptides'. Journal of Clinical Endocrinology & Metabolism, 90 (6). pp. 3680 - 3687. doi: 10.1210/jc.2004-2210 Keay, SD. , Vatish, M. , Karteris, E. , Hillhouse, EW. and Randeva, HS. (2004) 'The role of hCG in reproductive medicine'. BJOG, 111 (11). pp. 1218 - 1228. doi: 10.1111/j.1471-0528.2004.00412.x Parham, KL. , Zervou, S. , Karteris, E. , Catalano, RD. , et al. (2004) 'Promoter Analysis of Human Corticotropin-Releasing Factor (CRF) Type 1 Receptor and Regulation by CRF and Urocortin'. Endocrinology, 145 (8). pp. 3971 - 3983. doi: 10.1210/en.2004-0194 Karteris, E. , Chen, J. and Randeva, HS. (2004) 'Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system'. Journal of Clinical Endocrinology & Metabolism, 89 (4). pp. 1957 - 1962. doi: 10.1210/jc.2003-031778 Karteris, E. (2004) 'Expression and signalling characteristics of the corticotrophin-releasing hormone receptors during the implantation phase in the human endometrium'. Journal of Molecular Endocrinology, 32 (1). pp. 21 - 32. doi: 10.1677/jme.0.0320021 Karteris, E. , Grammatopoulos, D. and Hillhouse, EW. (2004) 'Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: Potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility'. Endocrinology, 145 (2). pp. 890 - 900. doi: 10.1210/en.2003-1210 Zervou, S. , Karteris, E. , Goumenou, AG. , Vatish, M. , et al. (2003) 'The Glu298→Asp polymorphism of the endothelial nitric oxide synthase gene is associated with endometriosis'. Fertility and Sterility, 80 (6). pp. 1524 - 1525. doi: 10.1016/S0015-0282(03)02204-0 Karteris, E. and Randeva, HS. (2003) 'Orexin Receptors and G-Protein Coupling: Evidence for Another “Promiscuous” Seven Transmembrane Domain Receptor'. Journal of Pharmacological Sciences, 93 (1). pp. 126 - 128. doi: 10.1254/jphs.93.126 Randeva, H. (2003) 'Circadian rhythmicity of salivary leptin in healthy subjects'. Molecular Genetics and Metabolism, 78 (3). pp. 229 - 235. doi: 10.1016/S1096-7192(03)00004-0