Silva, Elisabete - Brunel University - Department of Clinical Sciences

个人简介

2011-present: Lecturer in Human Toxicology. Institute for the Environment, Brunel University 2007–2011: Lecturer in Toxicology. School of Pharmacy, University of London 2003–2007: Postdoctoral Research Fellow. School of Pharmacy, University of London 1999–2004: Teaching Assistant. School of Pharmacy, University of London

研究领域

Institute for the Environment

近期论文

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Gérard, C. , Mestdagt, M. , Tskitishvili, E. , Communal, L. , et al. (2015) 'Combined estrogenic and anti-estrogenic properties of estetrol on breast cancer may provide a safe therapeutic window for the treatment of menopausal symptoms'. Oncotarget, 6 (19). pp. 17621 - 17636. Riverso, M. , Kortenkamp, A. and Silva, E. (2014) 'Non-tumorigenic epithelial cells secrete MCP-1 and other cytokines that promote cell division in breast cancer cells by activating ERα via PI3K/Akt/mTOR signaling'. International Journal of Biochemistry and Cell Biology, 53 pp. 281 - 294. doi: 10.1016/j.biocel.2014.05.023 Download publication Da Silva, DD. , Silva, E. and Carmo, H. (2014) 'Combination effects of amphetamines under hyperthermia - the role played by oxidative stress'. Journal of Applied Toxicology, 34 (6). pp. 637 - 650. doi: 10.1002/jat.2889 Da Silva, DD. , Silva, E. , Carvalho, F. and Carmo, H. (2014) 'Mixtures of 3,4-methylenedioxymethamphetamine (ecstasy) and its major human metabolites act additively to induce significant toxicity to liver cells when combined at low, non-cytotoxic concentrations'. Journal of Applied Toxicology, 34 (6). pp. 618 - 627. doi: 10.1002/jat.2885 Scholze, M. , Silva, E. and Kortenkamp, A. (2014) 'Extending the applicability of the dose addition model to the assessment of chemical mixtures of partial agonists by using a novel toxic unit extrapolation method'. PLoS ONE, 9 (2). doi: 10.1371/journal.pone.0088808 Download publication Dias Da Silva, D. , Carmo, H. , Lynch, A. and Silva, E. (2013) 'An insight into the hepatocellular death induced by amphetamines, individually and in combination: The involvement of necrosis and apoptosis'. Archives of Toxicology, 87 (12). pp. 2165 - 2185. doi: 10.1007/s00204-013-1082-9 da Silva, DD. , Silva, E. and Carrno, H. (2013) 'Cytotoxic effects of amphetamine mixtures in primary hepatocytes are severely aggravated under hyperthermic conditions'. TOXICOLOGY IN VITRO, 27 (6). pp. 1670 - 1678. doi: 10.1016/j.tiv.2013.04.010 da Silva, DD. , Carmo, H. and Silva, E. (2013) 'The risky cocktail: what combination effects can we expect between ecstasy and other amphetamines?'. ARCHIVES OF TOXICOLOGY, 87 (1). pp. 111 - 122. doi: 10.1007/s00204-012-0929-9 Marchese, S. and Silva, E. (2012) 'Disruption of 3D MCF-12A breast cell cultures by estrogens - An in vitro model for ER-mediated changes indicative of hormonal carcinogenesis'. PLoS ONE, 7 (10). doi: 10.1371/journal.pone.0045767 Download publication Modarai, M. , Silva, E. , Suter, A. , Heinrich, M. and Kortenkamp, A. (2011) 'Safety of Herbal Medicinal Products: Echinacea and Selected Alkylamides Do Not Induce CYP3A4 mRNA Expression'. Evidence Based Complementary Alternative Medicine, 2011 pp. 213021 - 213021. doi: 10.1093/ecam/nep174 Download publication Silva, E. , Rajapakse, N. , Scholze, M. , Backhaus, T. , et al. (2011) 'Joint Effects of Heterogeneous Estrogenic Chemicals in the E-Screen-Exploring the Applicability of Concentration Addition'. TOXICOLOGICAL SCIENCES, 122 (2). pp. 383 - 394. doi: 10.1093/toxsci/kfr103 Silva, D. , Silva, E. and Carmo, H. (2010) 'What combination effects can we expect from amphetamine designer drugs?'. Toxicology Letters, 196 pp. S148 - S148. doi: 10.1016/j.toxlet.2010.03.512 Silva, E. , Kabil, A. and Kortenkamp, A. (2010) 'Cross-talk between non-genomic and genomic signalling pathways - Distinct effect profiles of environmental estrogens'. TOXICOLOGY AND APPLIED PHARMACOLOGY, 245 (2). pp. 159 - +. doi: 10.1016/j.taap.2010.02.015 Lopez-Espinosa, M-J. , Silva, E. , Granada, A. , Molina-Molina, J-M. , et al. (2009) 'Assessment of the total effective xenoestrogen burden in extracts of human placentas'. Biomarkers, 14 (5). pp. 271 - 277. doi: 10.1080/13547500902893744 Kabil, A. , Silva, E. and Kortenkamp, A. (2008) 'Estrogens and genomic instability in human breast cancer cells - Involvement of Src/Raf/Erk signaling in micronucleus formation by estrogenic chemicals'. Carcinogenesis, 29 (10). pp. 1862 - 1868. doi: 10.1093/carcin/bgn138 Download publication Silva, E. , Scholze, M. and Kortenkamp, A. (2007) 'Activity of xenoestrogens at nanomolar concentrations in the E-screen assay'. Environmental Health Perspectives, 115 (SUPPL1). pp. 91 - 97. doi: 10.1289/ehp.9363 Download publication Silva, E. , Lopez-Espinosa, MJ. , Molina-Molina, J-M. , Fernandez, M. , et al. (2006) 'Lack of activity of cadmium in in vitro estrogenicity assays'. TOXICOLOGY AND APPLIED PHARMACOLOGY, 216 (1). pp. 20 - 28. doi: 10.1016/j.taap.2006.04.002 Rajapakse, N. , Silva, E. , Scholze, M. and Kortenkamp, A. (2004) 'Deviation from additivity with estrogenic mixtures containing 4-nonylphenol and 4-tert-octylphenol detected in the E-SCREEN assay'. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 38 (23). pp. 6343 - 6352. doi: 10.1021/es049681e Silva, E. , Rajapakse, N. and Kortenkamp, A. (2002) 'Something from "nothing" - Eight weak estrogenic chemicals combined at concentrations below NOECs produce significant mixture effects'. ENVIRONMENTAL SCIENCE & TECHNOLOGY, 36 (8). pp. 1751 - 1756. doi: 10.1021/es0101227 Rajapakse, N. , Silva, E. and Kortenkamp, A. (2002) 'Combining xenoestrogens at levels below individual no-observed-effect concentrations dramatically enhances steroid hormone action'. Environmental Health Perspectives, 110 (9). pp. 917 - 921. Download publication