个人简介

Claire Perks completed her PhD from the University of Bristol in 1995, in which she studied ‘The Role of the IGF axis in the Ovary’ in relation to fertility. She then continued these studies as a Postdoctoral Research Scientist at The Royal Veterinary College, University of London before joining Professor Jeff Holly’s team as a Research Associate in the University of Bristol, Department of Surgery.

研究领域

Epigenetic influence on and interactions of key dietary factors with the IGF axis and how this may influence breast and prostate cancer progressio

Claire is particularly interested in studying the epigenetic influence on and interactions of key dietary factors with the IGF axis and how this may influence breast and prostate cancer progression.

近期论文

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Perks, C, Zielinska, H, Wang, J, Jarrett, C, Frankow, A, Ladomery, MR, Bahl, A, Rhodes, A, Oxley, J & Holly, J, 2016, ‘Insulin receptor isoform variations in prostate cancer cells’. Frontiers in Endocrinology. Bull, CJ, Bonilla, C, Holly, JMP, Perks, CM, Davies, N, Haycock, P, Yu, OHY, Richards, JB, Eeles, R, Easton, D, Kote-Jarai, Z, Al Olama, AA, Benlloch, S, Muir, K, Giles, GG, MacInnis, RJ, Wiklund, F, Gronberg, H, Haiman, CA, Schleutker, J, Nordestgaard, BG, Travis, RC, Neal, D, Pashayan, N, Khaw, K-T, Stanford, JL, Blot, WJ, Thibodeau, S, Maier, C, Kibel, AS, Cybulski, C, Cannon-Albright, L, Brenner, H, Park, J, Kaneva, R, Batra, J, Teixeira, MR, Micheal, A, Pandha, H, Smith, GD & others 2016, ‘Blood lipids and prostate cancer: a Mendelian randomization analysis’. Cancer Medicine. Hackshaw-McGeagh, L, Lane, JA, Persad, R, Gillatt, D, Holly, JMP, Koupparis, A, Rowe, E, Johnston, L, Cloete, J, Shiridzinomwa, C, Abrams, P, Penfold, C, Bahl, A, Oxley, J, Perks, CM & Martin, R, 2016, ‘Prostate cancer - evidence of exercise and nutrition trial (PrEvENT): Study protocol for a randomised controlled feasibility trial’. Trials, vol 17. Adamczyk, LA, Williams, HR, Frankow, A, Ellis, HP, Haynes, HR, Perks, C, Holly, JMP & Kurian, KM, 2015, ‘Current Understanding of Circulating Tumor Cells - Potential Value in Malignancies of the Central Nervous System’. Frontiers in Neurology, vol 6., pp. 174 Mansor, R, Bahl, A, Holly, JMP & Perks, C, 2015, ‘The role of the IGF axis in epithelial-to-mesenchymal transition during the progression of prostate cancer’. Journal of Analytical Oncology, vol 4., pp. 157-170 Zeng, L, Zielinska, HA, Arshad, A, Shield, JP, Bahl, A, Holly, JMP & Perks, CM, 2015, ‘Hyperglycaemia-induced chemo-resistance in breast cancer cells: role of the estrogen receptor’. Endocrine-Related Cancer., pp. 125-134 Perks, CM, Holly, JM & Perks, C, 2015, ‘Epigenetic regulation of insulin-like growth factor binding protein-3 (IGFBP-3) in cancer’. Journal of cell communication and signaling, vol 9., pp. 159-66 Rosendahl, AH, Perks, CM, Zeng, L, Markkula, A, Simonsson, M, Rose, C, Ingvar, C, Holly, JMP & Jernström, H, 2015, ‘Caffeine and Caffeic Acid Inhibit Growth and Modify Estrogen Receptor and Insulin-like Growth Factor I Receptor Levels in Human Breast Cancer’. Clinical Cancer Research, vol 21., pp. 1877-87 Zeng, L, Perks, CM & Holly, JMP, 2015, ‘IGFBP-2/PTEN: A critical interaction for tumours and for general physiology?’. Growth Hormone and IGF Research, vol 25., pp. 103-7 Zielinska, HA, Bahl, A, Holly, JM & Perks, CM, 2015, ‘Epithelial-to-mesenchymal transition in breast cancer: a role for insulin-like growth factor I and insulin-like growth factor-binding protein 3?’. Breast cancer (Dove Medical Press), vol 7., pp. 9-19