Derrick Ong - National University of Singapore

个人简介

Awards 2018 NUS Early Career Research Award 2017 Singapore National Research Foundation Fellowship, Class of 2017 2017 NUS President’s Assistant Professorship August 2012 – September 2015 Odyssey Fellowship at UT MD Anderson Cancer Center August 2007 – March 2010 Skaggs-Oxford Scholarship August 2003 – July 2004 Research Scholarship at NUS 2003 Straits Times Bronze Medal For Best student in The B.Sc. Honors Examinations, NUS 1999 – 2003 Dean’s List at Faculty of Science, NUS (4 out of 5 eligible semesters)

研究领域

Understanding why brain stem/progenitor cell functional reserves decline with age How brain stem/progenitor cell activity can be enhanced during aging Cancerous brain stem cells (i.e. glioma stem cells) in Glioblastoma multiforme Regulation of telomerase in non-cancerous and cancerous brain stem cells Potential role of eroded telomeres in osteoarthritis

近期论文

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Leung J.Y., Chia K., Ong D.S.T. & Taneja R. Interweaving tumour heterogeneity into the cancer epigenetic-metabolism axis. Antioxidants & Redox Signaling, 2019, Accepted. Chiu H.Y., Tay E.X.Y., Ong D.S.T & Taneja R. Mitochondrial dysfunction at the centre of cancer therapy. Antioxidants & Redox Signaling, 2019, Accepted. Lee B.W.L.*, Ghode P.* & Ong D.S.T. Redox regulation of cell state and fate. Redox Biology, 2018, pii: S2213-2317(18)30899-1. * Equal contribution. Ong D.S.T.*, Hu B.*, Ho Y.W.*, Sauvé C.G., Bristow C.A., Wang Q., Multani A.S., Chen P., Nezi L., Jiang S., Gorman C.E., Monasterio M.M., Koul D., Marchesini M., Colla S., Jin E., Sulman E.P., Spring D.J., Yung, W.A., Verhaak R.G.W., Chin L., Wang Y.A. & DePinho R.A. PAF promotes stemness and radioresistance of glioma stem cells. PNAS, 2017, 114, E9086-95. * Equal contribution. Hu B.*, Wang Q.*, Wang Y.A.*, Hua S., Sauve C.G., Ong D.S.T., Lan Z.D., Chang Q., Ho Y.W., Marchesini M., Lu X., Zhong Y., Zhang J., Deng P., Tan Z., Wang G., Liao W.T., Corley L.J., Yan H., Zhang J., You Y., Liu N., Cai L., Finocchiaro G., Phillips J.J., Berger M.S., Spring D.J., Hu J., Sulman E.P., Fuller G.N., Chin L., Verhaak R.G.W., DePinho R.A. Epigenetic activation of WNT5A drives glioma stem cell differentiation and invasive growth. Cell, 2016, 167, 1281-95. * Equal contribution. (Featured in Cancer Discovery 2016.) Colla S.*, Ong D.S.T.*, Ogoti Y., Marchesini M., Mistry N.A., Clise-Dwyer K., Ang S.A., Storti P., Viale A., Giuliani N., Ruisaard K., Gomez I.G., Bristow C.A., Estecio M., Weksberg D.C., Ho Y.W., Hu B., Genovese G., Pettazzoni P., Multani A.S., Jiang S., Hua S., Ryan M.C., Carugo A., Nezi L., Wei Y., Yang H., D’Anca M., Zhang L., Gaddis S.., Gong T., Horner J.W., Heffernan T.P., Jones P., Cooper L.J.N., Liang H., Kantarjian H., Wang Y.A., Chin L., Bueso-Ramos C., Garcia-Manero G., & DePinho R.A. (2015) Telomere dysfunction drives aberrant hematopoietic differentiation and Myelodysplastic Syndrome. Cancer Cell, 2015, 27, 644-57. * Equal contribution. (Cancer Cell Preview 2015; Highlighted in Nature Reviews Cancer 2015 & Biocentury Innovations 2015; Featured in Cancer Discovery 2015; Science Translational Medicine Editors’ Choice 2015) Ong D.S.*, Wang Y.J.*, Tan Y.L.*, Yates J.R. 3rd, Mu T.W. & Kelly J.W. FKBP10 Depletion Enhances Glucocerebrosidase Proteostasis in Gaucher Disease Fibroblasts. Chemistry & Biology, 2013, 20, 403-15. * Equal contribution. (Chemistry & Biology Preview 2013.) Muller F.L.,* Colla S.*, Aquilanti E.*, Manzo V.E., Genovese G., Lee J., Eisenson D., Narurkar R., Deng P., Nezi L., Lee M.A., Hu B., Hu J., Sahin E., Ong D., Fletcher-Sananikone E., Ho D., Kwong L., Brennan C., Wang Y.A., Chin L., & DePinho R.A. Passenger Deletions Generate Therapeutic Vulnerabilities in Cancer. Nature, 2012, 488, 337-42. * Equal contribution. (Nature News & Views 2012; Highlighted in Nature Reviews Drug Discovery 2012.) Ong, D.S. & Kelly, J.W. Chemical and/or Biological Therapeutic Strategies to Ameliorate Protein Misfolding Diseases. Current Opinion in Cell Biology, 2011, 23, 231-8. (Cover image for April 2011 issue of Current Opinion in Cell Biology) Choi, S., Ong, D.S. & Kelly, J.W. A Stilbene that Binds Selectively to Transthyretin in Cells and Remains Dark Until it Undergoes a Chemoselective Reaction to Create a Bright Blue Fluorescent Conjugate. Journal of the American Chemical Society, 2010, 132, 16043-51. Ong, D.S., Mu, T.W., Palmer, A.E. & Kelly, J.W. Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis. Nature Chemical Biology, 2010, 6, 424-32. (Nature Chemical Biology News & Views 2010, Nature Chemical Biology Press Releases 2010.) Mu, T.W.*, Ong, D.S.*, Wang, Y.J., Balch, W.E., Yates, J.R., Segatori, L.* & Kelly, J.W. (2008) Chemical and Biological Approaches Synergize to Ameliorate Protein-Folding Diseases. Cell, 2008, 134, 769–81. * Equal contribution. (Science Editors’ Choice 2008; Faculty of 1000 Biology 2009; Highlighted in ACS Chemical Biology 2008 & Chemical and Engineering News 2008.) Ong, S.T., Ho, J.Z.S., Ho, B. & Ding, J.L. Iron withholding strategy in innate immunity. Immunobiology, 2006, 211: 295-314. Ong, D.S.T., Wang, L., Zhu, Y., Ho, B. & Ding, J.L. The response of ferritin to LPS and acute phase of Pseudomonas infection. Journal of Endotoxin Research, 2005, 11, 267-280.