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Can VEGF-C regulate VEGF-A induced changes in glomerular endothelial cell barrier properties in health and disease?

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Oltean, S, Qiu, Y, Ferguson, JK, Stevens, M, Neal, C, Russell, A, Kaura, A, Arkill, KP, Harris, K, Symonds, C, Lacey, K, Wijeyaratne, L, Gammons, M, Wylie, E, Hulse, RP, Alsop, C, Cope, G, Damodaran, G, Betteridge, KB, Ramnath, R, Satchell, SC, Foster, RR, Ballmer-Hofer, K, Donaldson, LF, Barratt, J, Baelde, HJ, Harper, SJ, Bates, DO & Salmon, AHJ, 2015, ‘Vascular Endothelial Growth Factor-A165b Is Protective and Restores Endothelial Glycocalyx in Diabetic Nephropathy’. Journal of the American Society of Nephrology, vol 26., pp. 1889-904 Ramnath, R, Foster, RR, Qiu, Y, Cope, G, Butler, MJ, Salmon, AH, Mathieson, PW, Coward, RJ, Welsh, GI & Satchell, SC, 2014, ‘Matrix metalloproteinase 9-mediated shedding of syndecan 4 in response to tumor necrosis factor α: a contributor to endothelial cell glycocalyx dysfunction’. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. Foster, RR, Armstrong, L, Baker, S, Wong, DWL, Wylie, EC, Ramnath, R, Jenkins, R, Singh, A, Steadman, R, Welsh, GI, Mathieson, PW & Satchell, SC, 2013, ‘Glycosaminoglycan Regulation by VEGFA and VEGFC of the Glomerular Microvascular Endothelial Cell Glycocalyx in Vitro’. The American journal of pathology, vol 183., pp. 604-16 Singh, A, Ramnath, RD, Foster, RR, Wylie, EC, Fridén, V, Dasgupta, I, Haraldsson, B, Welsh, GI, Mathieson, PW & Satchell, SC, 2013, ‘Reactive oxygen species modulate the barrier function of the human glomerular endothelial glycocalyx’. PLOS ONE, vol 8., pp. e55852 Singh, A, Friden, V, Dasqupta, I, Foster, R, Welsh, G, Tooke, J, Haraldsson, B, Mathieson, P & Satchell, S, 2011, ‘High glucose causes dysfunction of the human glomerular endothelial glycocalyx’. Am J Physiol Renal Physiol, vol 300(1)., pp. f40 - f48 Foster, R, Welsh, G, Satchell, S, Marlow, R, Wherlock, M, Pons, D, Mathieson, P, Bates, D & Saleem, M, 2010, ‘Functional distinctions in cytosolic calcium regulation between cells of the glomerular filtration barrier’. Cell Calcium, vol 48(1)., pp. 44 - 53 Foster, R, Zadeh, M, Welsh, G, Satchell, S, Ye, J, Mathieson, P, Bates, D & Saleem, M, 2009, ‘Flufenamic acid is a tool for investigating TRPC6-mediated calcium signalling in human conditionally immortalised podocytes and HEK293 cells’. Cell Calcium, vol 45(4)., pp. 384 - 390 Foster, R, 2009, ‘The importance of cellular VEGF bioactivity in the development of glomerular disease’. Nephron Exp Nephrol, vol 113(1)., pp. e8 - e15 Foster, R, Slater, S, Seckley, J, Kerjaschki, D, Bates, D, Mathieson, P & Satchell, S, 2008, ‘Vascular endothelial growth factor-C, a potential paracrine regulator of glomerular permeability, increases glomerular endothelial cell monolayer integrity and intracellular calcium’. The American journal of pathology, vol 173., pp. 938 - 948 Bevan, H, van den Akker, N, Qiu, Y, Polman, J, Foster, R, Yem, J, Nishikawa, A, Satchell, S, Harper, S, Groot, AG & Bates, D, 2008, ‘The alternatively spliced anti-angiogenic family of VEGF isoforms VEGFxxxb in human kidney development’. Nephron Physiology, vol 110., pp. 57 - 67

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