个人简介

讲授课程《兽医学》、《兽医学实验》、《人畜共患病》、《猪病学进展》等 华中农业大学教授、博士生导师，所在团队入选国家自然科学基金委创新研究群体。主要研究内容为肠外致病性大肠杆菌的基因组学与分子致病机理的研究以及疫苗和药物的开发；结核分枝杆菌的致病机理研究以及新药的研制；猪2型链球菌双组分信号调控系统调控机制的研究；近年来主持国家自然科学基金面上项目、青年项目；主持国家重点研发计划课题一项、子课题一项；主持教育部新教师基金1项；作为学术骨干参与了国家基础研究计划（973计划）、国家自然科学基金重点项目等课题。发表论文52篇，其中SCI论文45篇，第一作者或通讯作者SCI论文25篇，单篇最高IF：7.504。获得授权专利1项, 湖北省科技进步一等奖1项，博士论文获湖北省优秀博士论文。 教育经历 2001.09 - 2005.06，华中农业大学，动物医学专业毕业，农学学士 2005.09 - 2010.06， 华中农业大学，预防兽医学专业毕业，农学博士 2008.11 - 2010.05，伦敦大学卫生与热带医学院，联合培养博士研究 工作经历 2010.7-2012.12，华中农业大学讲师， 2013.1-2018.11，华中农业大学副教授、硕士生导师。 2018.11-至今，华中农业大学教授，博士生导师。 著作类 1.《兽医手册》参编。 科研项目 1. 病原菌代谢调控机制研究 2017.07 2. 畜禽重要胞内菌基因调控及其与宿主互作的分子机制 2017.07 3. 绿色山猪肉产业化生产技术研究与开发 2015.01 4. 猪肠外致病性大肠杆菌六型分泌系统致病机制研究 2015.01 5. 猪链球菌2型双组分信号转导系统883hk/rr功能研究 2012.01 6. 病原菌表面多糖的结构与功能2012.01 7. 猪链球菌2型双组分信号转导系统1660rr/hk调控机制研究 2012.01 主要奖励 1. 2013年获湖北省科技进步一等奖，猪链球菌病防控关键技术研究与应用,。 2. 2012湖北省优秀博士论文。

研究领域

为动物细菌病原微生物致病机理、免疫机理以及新型疫苗、药物的研发

动物细菌病原微生物基因组学、致病机理、免疫机理、新型疫苗与药物的研发

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Fei Rui-Hua#, Tan Chen#, Huang Yue, Chen Huan-Chun, Guo Ai-Zhen, Wang Hai-Lin, Hu Yong-Gang*. Self-Assembled Ti4+@Biospore Microspheres for Sensitive DNA Analysis. ACS Appl. Mater. Interfaces. 2017,9:34696-34705. 2.Xia Miaomiao, Li Zheng, Chen Yingyu, Xiang Yuqiang, Yang Li, Zhao Xiangwei, Guo Aizhen, Chen Huanchun, Tan Chen*, Hu Yonggang*. Protein self-assembly via Zr4+ ions on spore-based microspheres for immunoassays. Sensors and Actuators B. 2018,254:166-176. 3.Li Pei, Wang Rui, Dong Wenqi, Hu Linlin, Zong Bingbing, Zhang Yanyan, Wang Xiangru, Guo Aizhen, Zhang Anding, Xiang Yaozu, Chen Huanchun, Tan Chen*. Comparative Proteomics Analysis of Human Macrophages Infected with Virulent Mycobacterium bovis. Frontiers in Cellular and Infection Microbiology, 2017, 00065. 4.Liu Feng, Fu Jiyang, Liu Canying, Chen Jing, Sun Minhua, Chen Huanchun, Tan Chen*, Wang Xiangru*. Characterization and distinction of two flagellar systems inextraintestinal pathogenic Escherichia coli PCN033. Microbiol Res, 2017, 196:69−79. 5.Peng Ying, Wang Xiangru, Shou Jin, Zong Bingbing, Zhang Yanya, Tan Jia, Chen Jing, Hu Linlin, Zhu Yongwei, Chen Huanchun, Tan Chen*. Roles of Hcp family proteins in the pathogenesis of the porcine extraintestinal pathogenic Escherichia coli type VI secretion system. Sci Rep, 2016, 6:26816. 6.Chen Jing, Su Lijie, Wang Xiangru, Zhang Tao, Liu Feng, Chen Huanchun, Tan Chen*. Polyphosphate Kinase Mediates Antibiotic Tolerance in Extraintestinal Pathogenic Escherichia coli PCN033. Front Microbiol, 2016, 7:724. 7.Gao Rongsui#, Li Yue#, Lin Jingxia, Tan Chen*,Youjun Feng*. Unexpected complexity of multidrug resistance in the mcr-1-harbouring Escherichia coli. Sci China Life Sci, 2016, 59(7):732-734. 8.Li Zhencui#, Tan Chen#, Lin Jingxia, Youjun Feng*. Diversified variants of the mcr-1-carrying plasmid reservoir in the swine lung microbiota. Sci China Life Sci, 2016, 59(9):91-97. 9.Zhang Yanyan, Ding Dandan, Liu Manli, Yang Xiaopei, Zong Bingbing, Wang Xiangru, Chen Huanchun, Bei Weicheng, Tan Chen*. Effect of the glycosyltransferases on the capsular polysaccharidesynthesis of Streptococcus suis serotype 2. Microbiol Res, 2016, 185:45−54. 10.Ding Yi, Zhu Dongmei, Zhang Jianmin, Yang Longsheng, Wang Xiangru, Chen Huanchun, Tan Chen*. Virulence determinants, antimicrobial susceptibility, and molecular profiles of Erysipelothrix rhusiopathiae isolated from China. Emerg Microbes Infec, 2015,4(11):e69. 11.Liu Canying, Zheng Huajun, Yang Minjun, Xu Zhuofei, Wang Xiangru, Wei Liuya, Tang Biao, Liu Feng, Zhang Yanyan, Ding Yi, Tang Xibiao, Wu Bin, Timothy J. Johnson, Chen Huanchun, Tan Chen*. Genome analysis and in vivo virulence of porcine extraintestinal pathogenic Escherichia coli strain PCN033. BMC Genomics, 2015, 16: 717. 12.Zhang Yun#, Tan Chen#, Fei Ruihua, Liu Xiaoxiao, Zhou Yuan, Chen Jing, Chen Huanchun, Zhou Rui, and Hu Yonggang*.Sensitive Chemiluminescence Immunoassay for E. coli O157:H7 Detection with Signal Dual-Amplification Using Glucose Oxidase and Laccase. Anal Chem, 2014, 86: 115−1122. 13.Xu Juan, Fu Shulin, Liu Manli, Xu Qiaoxia, Bei,Weicheng, Chen,Huanchun, Tan Chen*. The two-component system NisK/NisR contributes to the virulence of Streptococcus suis serotype 2. Microbiol Res, 2014, 169: 541–546. 14.Wang Xiangru, Wei Liuya, Wang Bin, Zhang Ruixuan, Liu Canying, Bi Dingren, Chen Huanchun, Tan Chen*. Complete genome sequencing and characterization of an vian pathogenic Escherichia coli field isolate ACN001. Standards in Genomic Sciences, 2016, 11:13. 15.Wang xiangru, Hao Haihong, Xu Zhuofei, Zheng Huajun, Liu Canying, Wei Liuya, Zhang Ruixuan, Bi Dingren, Chen Huanchun, Tan Chen*. Plasmid-mediated multidrug resistance and virulence in an avian pathogenic Escherichia coli strain isolated in China. Journal of Global Antimicrobial Resistance, 2014,57–58. 16.Zong Bingbing, Liu Wugang, Zhang Yanyan, Wang Xiangru, Chen Huanchun, Tan Chen*. Effect of kpsM on the virulence of porcine extraintestinal pathogenic Escherichia coli. FEMS Microbiology Letters, 2016, Vol. 363, No. 21. 17.Tan Chen#, Tang Xibiao#, Zhang Xuan, Ding Yi , Zhao Zhanqin, Wu Bin*, Cai Xuwang , Liu Zhengfei, He Qigai , Chen Huanchun. Serotypes and virulence genes of extraintestinal pathogenic Escherichia coli isolates from diseased pigs in China. Vet J, 2012, 192:483–488. 18.Ding Yi, Tang Xibiao, Lu Ping, Wu Bin, Xu Zhuofei, Liu Wugang, Zhang Ruixuan, Bei Weicheng, Chen Huanchun, Tan Chen*. Clonal analysis and virulent traits of pathogenic extraintestinal Escherichia coli isolates from swine in China. BMC Vet Res, 2012, 8:140. 19.Tan Chen#, Xu Zhuofei#, Zheng Huajun, Liu Wugang, Tang Xibiao, Shou Jin, Wu Bin, Wang Shengyue, Zhao Guo-Ping, Chen Huanchun. Genome Sequence of Porcine Extraintestinal Pathogenic Escherichia coli. J Bacteriol, 2011, 193:5038. 20.Tan Chen, Liu Manli, Li Jinquan, Jin Meilin, Bei Weicheng, Chen Huanchun. SsPep contributes to the virulence of Streptococcus suis. Microb Pathogenesis, 2011, 51:319–324. 21.Li Jinquan#, Tan Chen#, Zhou Yang, Fu Shulin, Hu Linlin, Hu Jin, Chen Huanchun, Bei Weicheng. The two-component regulatory system CiaRH contributes to the virulence of Streptococcus suis 2. Vet Microbiol, 2011, 148:99–104. 22.Tang Xibiao#, Tan Chen#, Zhang Xuan, Zhao Zhanqin, Xia Xin, WuBin, Guo Aizhen, Zhou Rui, Chen Huanchun. Antimicrobial resistances of extraintestinal pathogenic Escherichia coli isolates from swine in China. Microb Pathogenesis, 2011, 50:207−212. 23.Tan Chen Liu Manli, Liu Jinlin, Yuan Fangyan , Fu Shulin, Liu Yuan, Jin Meilin, Bei Weicheng, Chen Huanchun. Vaccination with Streptococcus suis serotype 2 recombinant 6PGD protein provides protection against S. suis infection in swine. FEMS Microbiol Lett, 2009, 296:78–83. 24.Tan Chen, Liu Manli, Jin Meilin, Liu Jinlin, Chen Yan, Wu Tao, Fu Ting, Bei Weicheng, Chen Huanchun. The key virulence-associated genes of Streptococcus suis ktype 2 are upregulated and differentially expressed in vivo. FEMS Microbiol Lett, 2008, 278:108–114. 25.Tan Chen, Fu Shulin, Liu Manli, Jin Meilin, Liu Jinlin, Bei Weicheng, Chen Huanchun. Cloning, expression and characterization of a cell wall surface protein, 6-phosphogluconate-dehydrogenase, of Streptococcus suis serotype 2. Vet Microbiol, 2008, 130:363–370. 26.Liu Jinlin, Hu Linlin, Xu Zhuofei, Tan Chen, Yuan Fangyan, Fu Shulin, Cheng Hui, Chen Huanchun, Bei Weicheng. Actinobacillus pleuropneumoniae two-component system QseB/QseC regulates the transcription of PilM, an important determinant of bacterial adherence and virulence. Vet Microbiol, 2015, 177:184–192. 27.Hou Bo, MengXian-Rong, Zhang Li-Yuan, Tan Chen, Jin Hui, Zhou Rui, Gao Jian-Feng, WuBin, Li Zi-Li, Liu Mei, Chen Huan-Chun, Bi Ding-Ren, and Li Shao-Wen. TolC Promotes ExPEC Biofilm Formation and Curli Production in Response to Medium Osmolarity. Biomed Research International, 2014,574274. 28.Liu Canying, Chen Zhaohui, Tan Chen, Liu Wugang, Xu Zhuofei, Zhou Rui, Chen Huanchun. Immunogenic characterization of outer membrane porins OmpC and OmpF of porcine extraintestinal pathogenic Escherichia coli. FEMS Microbiol Lett. 2012, 337(2):104−11. 29.Fu Shulin, Zhang Minmin, Ou Jiwen, Liu Huazhen, Tan Chen, Liu Jinlin, Chen Huanchun, Bei Weicheng. Construction and immune effect of Haemophilus parasuis DNA vaccine encoding glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in mice. Vaccine. 2012, 30:6839−6844. 30.Fu Shulin, Yuan Fangyan, Zhang Minmin, Tan Chen, Chen Huanchun, Bei Weicheng. Cloning, expression and characterization of a cell wall surface protein, 6-phosphogluconate dehydrogenase, of Haemophilus parasuis. Res Vet Sci, 2012, 93:57−62. 31.Yuan Fangyan, Liu Jinlin, Guo Yi, Tan Chen, Fu Shulin, Zhao Jin, Chen Huanchun, Bei Weicheng. Influences of ORF1 on the Virulence and Immunogenicity of Actinobacillus pleuropneumoniae. Curr Microbiol, 2011, 63:574−80. 32.Liu Manli, Fang Liurong, Tan Chen, Long Tiansi, Chen Huanchun, Xiao Shaobo. Understanding Streptococcus suis serotype 2 infection in pigs through a transcriptional approach. BMC Genomics. 2011, 20:253. 33.Li Jinquan, Xia Jing, Tan Chen, Zhou Yang, Wang Yan, Zheng Chengkun, Chen Huanchun, Bei Weicheng. Evaluation of the immunogenicity and the protective efficacy of a novel identified immunogenic protein, SsPepO, of Streptococcus suis serotype 2. Vaccine. 2011, 29:6514−6519. 34.Liu Manli, Tan Chen, Fang Liurong, Xiao Shaobo, Chen Huanchun. Microarray analyses of THP-1 cells infected with Streptococcus suis serotype 2. Vet Microbiol, 2011，150:126-31. 35.Wu Tao, Yuan Fangyan, Chang Haitao, Zhang Lin, Chen Guanping, Tan Chen, Chen Huanchun, Bei Weicheng. Identification of a novel angiogenin inhibitor 1 and its association with hyaluronidase of Streptococcus suis serotype 2. Microb Pathog, 2010, 49:32−37. 36.Liu Jinlin, Chen Xia, Tan Chen, Guo Yi, Chen Yan, Fu Shulin, Bei Weicheng, Chen Huanchun. In-vivo induced RTX toxin ApxIVA is essential for the full virulence of Actinobacillus pleuropneumoniae. Vet Microbiol, 2009, 137: 282−289. 37.Wu Tao, Chang Haitao, Tan Chen, Bei Weicheng, Chen Huanchun. The orphan response regulator RevSC21controls the attachment of Streptococcus suis serotype-2 to human laryngeal epithelial cells and the expression of virulence genes. FEMS Microbiol Lett, 2009, 292 :170–181. 38.Liu Jinlin, Tan Chen, Li Jingquan, Chen Huiwen, Xu Peng, He Qigai, Bei Weicheng, Chen Huanchun. Characterization of ISApl1, an insertion element identified from Actinobacillus pleuropneumoniae field isolate in China. Vet Microbiol, 2008, 132: 348−354. 39.Liu Jinlin, Chen Xia, Lin Liwen, Tan Chen, Chen Yan, Guo Yi, Jin Meilin, Guo Aizhen, Bei Weicheng*, Chen Huanchun. Potential use an Actinobacillus pleuropneumoniae double mutant strain DeltaapxIICDe