蒋明 - 上海交通大学 - 生命科学技术学院

个人简介

教育经历 2005. 01 ~ 2008. 08：香港科技大学，化学专业，获博士学位 2001. 09 ~ 2004. 08：香港科技大学，生物化学专业，获硕士学位 1997. 09 ~ 2001. 06：复旦大学, 化学专业，获学士学位工作经历 2013.05~至今：上海交通大学，生命科学技术学院，副研究员 2011.09 ~ 2013.05: 纽约州立大学水牛城分校，化学与生物工程专业，博士后 2010.09 ~ 2011.08: 塔夫茨大学，化学与生物工程专业，博士后 2008.09 ~ 2010.08: 香港科技大学，化学专业，博士后

研究领域

天然产物的合成生物学研究天然产物的异源生物合成通过代谢工程手段达到天然产物产量的提高和结构的改变

近期论文

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Chen M, Ma X, Chen X, Jiang M, Song H, Guo Z. Identification of a hotdog-fold thioesterase involved in the biosynthesis of menaquinone in Escherichia coli. J Bacteriol., 2013 Apr 5. [Epub ahead of print]. Sun Y, Song H, Li J, Li Y, Jiang M, Zhou J, Guo Z.H. Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme a synthase from the crotonase fold superfamily. PLoS One, 2013, 8(4):e63095. Johnstona JM, Jiang M, Guo Z, Bakera E.N. The Structure of E. coli Native MenH and Two Active Site Mutants. Plos One, 2013 8(4):e61325. Jiang M, Zhang H, Pfeifer BA. The logic, experimental steps, and potential of heterologous natural product biosynthesis featuring the complex antibiotic erythromycin A produced through E. coli. J. Vis. Exp., 2013, (71):e4346. Jones C.H, Chen C.K, Jiang M, Fang L, Cheng C, Pfeifer B.A. Synthesis of cationic polylactides with tunable charge densities as nanocarriers for effective gene delivery. Mol. Pharm., 2013, 10(3): 1138-1145. Jiang M, Pfeifer BA. Downstream reactions and engineering in the reconstituted pathways for Taxol and other isoprenoid natural products. Appl. Microbiol. Biotechnol., 2012, 94(4): 841-849. Jiang M, Stephanopoulos G, Pfeifer BA. Toward biosynthetic design and implementation of Escherichia coli-derived paclitaxel and other heterologous polyisoprene compounds. Appl. Environ. Microb., 2012, 78(8): 2497-2504. Sun Y, Song H, Li J, Jiang M, Li Y, Zhou J, Guo Z. Active Site Binding and Catalytic Role of Bicarbonate in 1,4-Dihydroxy-2-naphthoyl Coenzyme A Synthases from Vitamin K Biosynthetic Pathways. Biochemistry, 2012, 51 (22), 4580–4589. Zhang H, Skalina K, Jiang M, Pfeifer BA. Improved E. coli erythromycin a production through the application of metabolic and bioprocess engineering. Biotechnol. Prog., 2012, 28 (1): 292-296. Chen M.J, Jiang M, Sun Y.R, Guo ZF, Guo Z. Stabilization of the second oxyanion intermediate by 1,4-dihydroxy-2-naphthoyl coenzyme A synthase of the menaquinone pathway: Spectroscopic evidence for the involvement of a conserved aspartic acid. Biochemistry, 2011, 50 (26): 5893-5904. Jiang M, Chen M, Guo ZF, Guo Z. A bicarbonate cofactor modulates 1,4-dihydroxy -2-naphthoyl-coenzyme a synthase in menaquinone biosynthesis of Escherichia coli. J. Biol. Chem., 2010, 285 (39): 30159-30169. Johnston JM, Jiang M, Guo Z, Baker EN. Structural and functional analysis of Rv0554 from Mycobacterium tuberculosis: testing a putative role in menaquinone biosynthesis. Acta Crystallogr D Biol Crystallogr., 2010, 66 (Pt 8): 909-917. Guo ZF, Jiang M, Zheng S, Guo Z. Structural change of the enterobactin synthetase in crowded solution and its relation to crowding-enhanced product specificity in nonribosomal enterobactin biosynthesis. Bioorg Med Chem Lett., 2010, 20 (13): 3855-3858. Jiang M, Chen X, Wu X.H, Chen M, Wu Y.D, Guo Z. Catalytic mechanism of SHCHC synthase in the menaquinone biosynthesis of Escherichia coli: identification and mutational analysis of the active site residues. Biochemistry, 2009, 48 (29): 6921-6931. Jiang M, Chen X, Guo ZF, Cao Y, Chen M, Guo Z. Identification and characterization of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli. Biochemistry, 2008, 47 (11): 3426-3434. Guo ZF, Jiang M, Zheng S, Guo Z. Suppression of linear side products by macromolecular crowding in nonribosomal enterobactin biosynthesis. Org. Lett., 2008, 10 (4): 649-652. Jiang M, Chen M, Cao Y, Yang Y, Sze K.H, Chen X, Guo Z. Determination of the stereochemistry of 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate, a key intermediate in menaquinone biosynthesis. Org. Lett., 2007, 9 (23): 4765-4767. Jiang M, Cao Y, Guo Z.F, Chen M, Chen X, Guo Z.H. Menaquinone biosynthesis in Escherichia coli: identification of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate as a novel intermediate and re-evaluation of MenD activity. Biochemistry, 2007, 46 (38): 10979-10989. Jiang M, Guo Z. Effects of macromolecular crowding on the intrinsic catalytic efficiency and structure of enterobactin-specific isochorismate synthase. J. Am. Chem. Soc., 2007, 129 (4): 730-731.