赵剑楠 - 大连理工大学

个人简介

赵剑楠博士毕业于四川大学，师从冯小明教授，博士研究方向为烯酮亚胺参与的不对称Mannich反应。2015年加入加州大学洛杉矶分校(UCLA) Ohyun Kwon教授课题组开展博士后研究工作，首次实现了可见光催化的交叉[2+2]环加成反应。同时，开展了可再生膦催化剂在不对称Mitsunobu反应、不对称Wittig反应中的反应性研究。目前为止，已取得了一系列创新性研究成果，在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Org. Lett., Chem. Commun., 以及Synlett等刊物发表多篇SCI论文。入选中德科学中心林岛项目，受邀参加第65届德国林岛诺贝尔奖获得者大会。教育经历 2010.92015.8 四川大学有机化学博士 2006.92010.8 四川大学化学学士 2003.92006.8 沈阳二中工作经历 2018.10至今大连理工大学特聘研究员 2015.92018.9 美国加州大学洛杉矶分校博士后研究助理

研究领域

新型P-手性膦催化剂的设计合成及其在不对称合成中的应用。光化学、电化学合成等绿色有机合成方法学。手性药物及生物活性化合物的高效合成和应用

近期论文

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Jia-Nan Mo, Shengbin Sun, Huiwei Xu, Hanyu Shu, Jiannan Zhao* "Synthesis of γ‑Oxo-phosphonates via N‑Heterocyclic CarbeneCatalyzed Acylphosphorylation of Alkenes" Org. Lett. 2024, 26, 2197−2201. Hanyu Shu#, Jia-Nan Mo#, Wen-Deng Liu, Jiannan Zhao* "Synthesis of Pyrroloindolines via N‑Heterocyclic Carbene Catalyzed Dearomative Amidoacylation of Indole Derivatives" Org. Lett. 2023, 25, 8677−5584. Junqi Su, Aobo Chen, Guofeng Zhang, Ziyu Jiang, Jiannan Zhao* "Photocatalytic Phosphine-Mediated Thioesterification of Carboxylic Acids with Disulfides" Org. Lett. 2023, 25, 8033−8037. Junqi Su, Jia-Nan Mo, Guofeng Zhang, Ziyu Jiang, Jiannan Zhao* "A Practical Approach for Oligopeptide Synthesis via Synergistic Photoredox, Cobaloxime and Organophosphorus Triple Catalysis" Org. Chem. Front. 2023, 10, 4895−4904. Huiwei Xu, Wanyao Zheng, Wen-Deng Liu, Yuqiao Zhou,* Luqing Lin, Jiannan Zhao* "Silylacylation of Alkenes through N‑Heterocyclic Carbene Catalysis" Org. Lett. 2023, 25, 5579−5584. Wencheng Han, Wen-Deng Liu, Junqi Su, Jiannan Zhao* "Deoxygenation of Oximes for the Synthesis of Pyrrolines via Hydroimination Cyclization" Org. Biomol. Chem. 2023, 21, 3350−3354. Huiwei Xu, Jia-Nan Mo, Wen-Deng Liu, Jiannan Zhao* "N-Heterocyclic Carbene-Catalyzed Remote C(sp3)–H Acylation of Amides" Tetrahedron Lett. 2023, 121, 154483. Wen-Deng Liu#, Woojin Lee#, Hanyu Shu, Chuyu Xiao, Huiwei Xu, Xiangyang Chen, Kendall N. Houk*, Jiannan Zhao* "Diastereoselective Radical Aminoacylation of Olefins through N-Heterocyclic Carbene Catalysis" J. Am. Chem. Soc., DOI: 10.1021/jacs.2c11209. Wencheng Han, Junqi Su, Jia-Nan Mo, Jiannan Zhao* "Photoredox Catalytic Phosphine-Mediated Deoxygenation of Hydroxylamines Enables the Construction of N-Acyliminophosphoranes" Org. Lett. 2022, 24, 6247−6251. Junqi Su, Jia-Nan Mo, Xiangyang Chen, Alexander Umanzor, Zheng Zhang, Kendall N. Houk, Jiannan Zhao* “Generation of Oxyphosphonium Ions by Photoredox/Cobaloxime Catalysis for Scalable Amide and Peptide Synthesis in Batch and Continuous-Flow” Angew. Chem. Int. Ed., 2022, 61, e202112668. Jia-Nan Mo, Junqi Su, Jiannan Zhao* "The Asymmetric A3(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines" Molecules 2019, 24, 1216. Jiannan Zhao, Jonathan L. Brosmer, Qingxuan Tang, Zhongyue Yang, K. N. Houk, Paula L. Diaconescu, Ohyun Kwon*“Intramolecular Crossed [2+2] Photocycloaddition through Visible Light-Induced Energy Transfer”J. Am. Chem. Soc. 2017, 139, 9807−9810. Jiannan Zhao, Bing Fang, Weiwei Luo, Xiaoyu Hao, Xiaohua Liu, Lili Lin, and Xiaoming Feng* “Enantioselective Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Silyl Ketene Imines with Isatin-Derived Ketimines”Angew. Chem. Int. Ed., 2015, 54, 241–244. Jiannan Zhao, Xiaohua Liu, Weiwei Luo, Mingsheng Xie, Lili Lin, and Xiaoming Feng* “Asymmetric Synthesis of β-Amino Nitriles through a ScIII-Catalyzed Three-Component Mannich Reaction of Silyl Ketene Imines”Angew. Chem. Int. Ed., 2013, 52, 3473–3477. Jiannan Zhao, Ke Zheng, Yang Yang, Jian Shi, Lili Lin, Xiaohua Liu, Xiaoming Feng*“Asymmetric Mukaiyama Aldol Reaction Catalyzed by C2-Symmetric N,N'-Dioxide–Ni(II) Complex”Synlett, 2011, 903–906.