王磊 - 中国药科大学

个人简介

教育经历 2013/09-2018/06，中国药科大学，药学院，博士（硕博连读） 2009/09-2013/07，中国药科大学，药学院，学士工作经历 2023/12-至今，中国药科大学，药学院，研究员/博士生导师 2021/09-2023/12，中国药科大学，药学院，副教授/博士生导师 2020/06-2021/08，中国药科大学，药学院，副教授/硕士生导师 2018/03-2020/05，中国药科大学，药学院，师资博士后学术荣誉 2023/12，中国药科大学兴药青创学者 2023/07，江苏省优秀青年科学基金获得者 2022/03，江苏省科技创新U35创新奖 2021/10，中国科协青年人才托举工程学术兼职 2023/09，《中国药学杂志》青年编委 2023/06，《中国药科大学学报》青年编委 2021/10，药学学报/Acta Pharmaceutica Sinica B中英双刊青年编委 2021/10，南京药学会药物化学专业委员会委员/秘书

研究领域

1. 靶向分子伴侣系统的创新药物设计 2. 基于磷酸酶蛋白功能的创新药物设计 3. 多特异功能分子的设计策略研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Zhang, Q. Y.; Wu, X. X.; Zhang, H. H.; Wu, Q. Y.; Fu, M.; Hua, L. W.; Zhu, X. Y.; Guo, Y. Q.; Zhang, L. S.*, You, Q. D.*, Wang, L.*. Protein phosphatase 5-recruiting chimeras for accelerating apoptosis signal-regulated kinase 1 dephosphorylation with antiproliferative activity. J. Am. Chem. Soc. 2023, 145(2), 1118-1128. (IF: 15.0) Hua, L.W.; Wang, D. N.; Wang, K. R.; Wang, Y. X.; Gu, J. Y.; Zhang, Q. Y.; You, Q. D.; Wang, L.* Design of tracers in fluorescence polarization assay for extensive application in small molecule drug discovery. J. Med. Chem. 2023, 66(16):10934-10958. (IF:7.3) Ma, C. Y.1; Wu, J.1; Wang, L.1; Ji, X. J.; Wu, Y. B.; Miao, L.; Chen, D. H.; Zhang, L. L.; Wu, Y. Z.; Feng, H. W.; Tang, Y.; Zhou, Q. H.; Pei, J. J.; Yang, X. L.; Xu, D.; You, Q. D.; Xie, Y., Discovery of Clinical Candidate NTQ1062 as a Potent and Bioavailable Akt Inhibitor for the Treatment of Human Tumors. J. Med. Chem. 2022, 65 (12), 8144-8168. (IF: 8.0) Liu, W.; Jiang, J. S.; Lin, Y. T.; You, Q. D.*; Wang, L.* Insight into thermodynamic and kinetic profiles in small-molecule optimization. J. Med. Chem. 2022, 65(16): 10809-10847. (IF: 8.0) Hua, L. W.; Zhang, Q. Y.; Zhu, X. Y.; Wang, R. N.; You, Q. D.*; Wang, L.*, Beyond Proteolysis-Targeting Chimeric Molecules: Designing Heterobifunctional Molecules Based on Functional Effectors. J. Med. Chem. 2022, 65 (12), 8091-8112. (IF: 8.0) Xu, Y. X.; Feng, K. H.; Zhao, H. C.; Di, L. Q.; Wang, L.*; Wang, R. N.*, Tumor-derived extracellular vesicles as messengers of natural products in cancer treatment. Theranostics. 2022, 12 (4), 1683-1714. (IF: 11.6) Wu, X. X.; Zhang, Q. Y.; Guo, Y. Q.; Zhang, H. H.; Guo, X. K.*; You, Q. D.*; Wang, L.*, Methods for the Discovery and Identification of Small Molecules Targeting Oxidative Stress-Related Protein-Protein Interactions: An Update. Antioxidants. 2022, 11 (4). (IF: 7.7) Zhang, Q.; Fan, Z.; Zhang, L.; You, Q.*; Wang, L.*, Strategies for Targeting Serine/Threonine Protein Phosphatases with Small Molecules in Cancer. J. Med. Chem. 2021, 64 (13), 8916-8938. (IF: 8.0) Wang, L.; Zhang, Q. Y.; You, Q. D.*, Targeting the HSP90-CDC37-kinase chaperone cycle: A promising therapeutic strategy for cancer. Med. Res. Rev. 2021. (IF: 12.4) Wang, L.; Xu, X.; Jiang, Z.*; You, Q.*, Modulation of protein fate decision by small molecules: targeting molecular chaperone machinery. Acta Pharm. Sin. B. 2020, 10 (10), 1904-1925. (IF: 14.9) Wang, L.; Jiang, J.; Zhang, L.; Zhang, Q.; Zhou, J.; Li, L.; Xu, X.*; You, Q.*, Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer. J. Med. Chem. 2020, 63 (3), 1281-1297. (IF: 8.0) Wang, L.; Zhang, L.; Li, L.; Jiang, J.; Zheng, Z.; Shang, J.;Wang, C.; Chen, W.; Bao, Q.; Xu, X.; Jiang, Z.*; Zhang, J.*; You, Q.*, Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer. Sci. Adv. 2019, 5 (9), eaax2277. (IF: 14.9)