吴淑可 - 华中农业大学 - 生命科学技术学院

个人简介

吴淑可博士主要从事生物催化、酶工程、生物制药、合成生物学的教学与研究。曾在新加坡国立大学、美国麻省理工学院、瑞士巴塞尔大学、德国格赖夫斯瓦尔德大学开展研究工作。在多酶级联催化，化学-酶级联催化，人工金属酶，酶定向进化，合成生物学等方向取得了一系列成果。在Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed., ACS Catal., Chem. Soc. Rev., 等主流期刊上发表论文30多篇，申请国际专利3项。回国后，他致力于酶与合成生物学在制药、化工和农业方面的应用基础研究，积极响应生物医药产业升级的需求，契合国家“双碳”、绿色可持续发展的重大战略。获得国家自然科学基金（青年，2021海外优青），德国洪堡学者奖学金，欧盟玛丽居里行动计划卓越奖，瑞士政府优秀奖学金，新加坡-麻省理工联盟奖学金等资助。教育经历 2010.7——2015.11 新加坡国立大学 > 化学工程与制药工程 > 博士学位 > 哲学博士学位 2006.9——2010.6 北京大学 > 生物技术 > 学士 > 理学学士学位工作经历 2020.12-至今华中农业大学 > 生命科学技术学院 > Professor

研究领域

新酶发现与分子酶工程：面向医药、工业、农业等需求 1. 工业生物技术与绿色生物制造、生物制药、酶工程与生物催化。重点关注可用于农业系统中的酶，农用化学品和植物天然产物的发现和生物制造。 2. 从微生物中发现新酶催化反应/代谢途径等，并充分开发其新反应用于生物合成等应用。微生物工程与合成生物学构建新型的微生物或微生物与其他物质科学的复合系统（合成生物学），实现有趣、有应用价值的功能，例如合成药品和材料，检测和降解污染物等

近期论文

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Shuke Wu, #* Chao Xiang, # Yi Zhou, Mohammad Saiful Hasan Khan, Weidong Liu, Christian G. Feiler, Ren Wei, Gert Weber, Matthias Höhne, Uwe T. Bornscheuer*. A growth selection system for the directed evolution of amine-forming or converting enzymes. Nature Communications 2022, 13, 7458.. Shuke Wu,* Uwe T. Bornscheuer*. A Chemoenzymatic Cascade with the Potential to Feed the World and Allow Humans to Live in Space. Engineering Microbiology 2022, 2, 100006. Yi Zhou, Shuke Wu,* Uwe T. Bornscheuer*. Recent advances in (chemo)enzymatic cascades for upgrading bio-based resources. Chemical Communications 2021, 57, 10661-10674. 吴淑可*，周颐，王文，张巍，高鹏飞，李智*. 从单酶催化到多酶级联催化——从王义翘教授在酶技术领域的贡献说开去. 合成生物学2021, 2 (4), 543-558. Shuke Wu, Radka Snajdrova, Jeffrey C. Moore, Kai Baldenius,* Uwe T. Bornscheuer*. Biocatalysis: Enzymatic Synthesis for Industrial Applications. Angewandte Chemie International Edition 2021, 60 (1), 88-119. Dong Yi, # Thomas Bayer, # Christoffel P. S. Badenhorst, # Shuke Wu, # Mark Doerr, # Matthias Höhne,# Uwe T. Bornscheuer*. Recent trends in biocatalysis. Chemical Society Review 2021, 50 (14), 8003-8049. Shuke Wu,* Yi Zhou, Daniel Gerngross, Markus Jeschek, Thomas R. Ward*. Chemo-enzymatic Cascades to Produce Cycloalkenes from Bio-based Resources. Nature Communications 2019, 10, 5060. Shuke Wu,# Yi Zhou,# Johannes G. Rebelein,# Miriam Kuhn, Hendrik Mallin, Jingming Zhao, Nico V. Igareta, Thomas R. Ward*. Breaking Symmetry: Engineering Single-Chain Dimeric Streptavidin as Host for Artificial Metalloenzymes. Journal of the American Chemical Society 2019, 141, 15869-15878. Shuke Wu, Yi Zhou, Zhi Li*. Biocatalytic Selective Functionalisation of Alkenes via Single-step and One-pot Multi-step Reactions. Chemical Communications 2019, 55, 883-896. Shuke Wu, Zhi Li*. Whole-Cell Cascade Biotransformations for One-Pot Multistep Organic Synthesis. ChemCatChem 2018, 10, 2164-2178. Shuke Wu, Ji Liu, Zhi Li*. Biocatalytic Formal Anti-Markovnikov Hydroamination and Hydration of Aryl Alkenes. ACS Catalysis 2017, 7, 5225-5233. Shuke Wu, Yi Zhou, Daniel Seet, Zhi Li*. Regio- and Stereoselective Oxidation of Styrene Derivatives to Arylalkanoic Acids via One-Pot Cascade Biotransformations. Advanced Synthesis & Catalysis 2017, 359, 2132-2141. Shuke Wu, Ji Liu, Zhi Li*. Organic Synthesis via Oxidative Cascade Biocatalysis. Synlett 2016, 27, 2644-2658. Yi Zhou,# Shuke Wu,# Zhi Li*. Cascade Biocatalysis for Sustainable Asymmetric Synthesis: from Biobased ʟ-Phenylalanine to High-value Chiral Chemicals. Angewandte Chemie International Edition 2016, 55, 11647-11650. Shuke Wu, Yi Zhou, Tianwen Wang, Heng-Phon Too, Daniel I. C. Wang, Zhi Li*. Highly Regio- and Enantioselective Multiple Oxy- and Amino-functionalizations of Alkenes by Modular Cascade Biocatalysis. Nature Communications 2016, 7, 11917. Shuke Wu, Yongzheng Chen, Yi Xu, Aitao Li, Qisong Xu, Anton Glieder, Zhi Li*. Enantioselective trans-Dihydroxylation of Aryl Olefins by Cascade Biocatalysis with Recombinant Escherichia coli Coexpressing Monooxygenase and Epoxide Hydrolase. ACS Catalysis 2014, 4, 409-420. Shuke Wu, Aitao Li, Yit Siang Chin, Zhi Li*. Enantioselective Hydrolysis of Racemic and Meso-epoxides with Recombinant Escherichia coli Expressing Epoxide Hydrolase from Sphingomonas sp. HXN-200: Preparation of Epoxides and Vicinal Diols in High ee and High Concentration. ACS Catalysis 2013, 3, 752-759.