个人简介

NSF CAREER Award 2002; PECASE Award 2004; Georgia Tech Blanchard Assistant Professorship 2005; Georgia Tech Hesburgh Teaching Fellow 2007; Georgia Tech College of Sciences Faculty Mentor Award 2009; Georgia Tech Faculty Woman of Distinction Award 2009; University of Gothenburg Waernska Guest Professorship 2010; Georgia Tech Sigma Xi Best Faculty Paper Award 2010; Silverstein-Simenone Award of the International Society of Chemical Ecology 2012; Elected Fellow of the AAAS 2012

研究领域

Biochemistry/Characterization/Chemical and Biological Imaging/Chemical Biology/Environmental Chemistry/Medicinal Chemistry/Organic Chemistry

Most organisms use chemical signals to assess their environment and to communicate with others. Chemical cues for defense, mating, habitat selection, and food tracking are crucial, widespread in occurrence, and structurally and functionally diverse. Yet, our knowledge of chemical signaling is patchy, especially in marine environments. Processes such as oceanic primary production affect global climate, human health, and our sustainable use of environmental resources. In our research the Kubanek group asks, "How do marine organisms use chemicals to solve critical problems of competition, predation, disease, and reproduction?" We use an integrated approach to understand how marine natural products function as chemical cues in ecological interactions - working from the molecular to the community level. We also use ecological insights about how marine organisms use chemical cues to guide our discovery of novel natural products for drug discovery. We have core collaborations with research groups at Georgia Tech's Center for Aquatic Chemical Ecology, in which our group plays key roles as organic chemists, chemical ecologists, and chemical biologists. Ongoing projects include: 1) Waterborne chemical cues in the marine plankton: a systems biology approach (including metabolomics); 2) Exploration, conservation, and development of marine biodiversity in Fiji (including drug discovery, mechanisms of action, and chemical ecology); 3) Sensory environment and predator chemical signal properties in determining non-consumptive effect strength in cascading interactions on oyster reefs; 4) Regulation of red tide toxicity by chemical cues from marine zooplankton; 5) Chemoreception of prey chemical defenses on tropical coral reefs.

近期论文

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Teasdale, M. E., Shearer, T. L., Engel, S., Alexander, T. S., Fairchild, C. R., Le Roch, K., Prudhomme, J., Aalbersberg, W., Hay, M. E., Kubanek, J.(2012) Bromophycoic acids: bioactive natural products from a Fijian red alga Callophycus sp. Journal of Organic Chemistry 77:8000-8006. Cervantes, S., Stout, E. P., Prudhomme J., Engel, S., Bruton, M., Cervantes, M., Carter, D., Tae-Chang, Y., Hay, M. E., Aalbersberg, W., Kubanek, J., Le Roch, K. (2012) High content live cell imaging for the discovery of new antimalarial marine natural products. BMC Infectious Diseases 12:1. Rasher, D. B., Stout, E. P., Engel, S., Kubanek, J., Hay, M. E. (2011) Macroalgal terpenes function as allelopathic agents against reef corals. Proceedings of the National Academy of Sciences 108:17726-17731. Redshaw, C. H., Sutter, D. A., Lim-Hing, K., Heckman, M. L., Jakobsson, S. L., Naar, J., Kubanek. J. (2011) Tracking losses of brevetoxins on exposure to phytoplankton competitors: Ecological impacts. Harmful Algae 12:119-124. Zhang, J. L., Kubanek, J., Hay, M. E., Aalbersberg, W., Ye, W. C., Jiang, R. W. (2011) Rapid identification of triterpenoid sulfates and hydroxy fatty acids including two new constituents from Tydemania expeditionis by liquid chromatography-mass spectrometry. Journal of Mass Spectrometry 46:908-916. Stout, E. P., Cervantes, S., Rudhomme, J., France, S., La Clair, J. J., Le Roch, K., Kubanek, J. (2011). Bromophycolide A targets heme crystallization in the human malaria parasite Plasmodium falciparum. ChemMedChem, 6(9), 1572-1577. Zhang, J. L., Kubanek, J., Hay, M. E., Aalbersber, W., Ye, W. C., Jiang, R. W. (2011). Rapid identification of triterpenoid sulfates and hydroxy fatty acids including two new constituents from Tydemania expeditions by liquid chromatography-mass spectrometry. Journal of Mass Spectrometry, 46(9), 908-916 Sieg, R. D., Poulson-Ellestad, K. L., & Kubanek, J. (2011). Chemical ecology of the marine plankton. Natural Product Reports, 28(2), 388-399. Lin, A. S., Engel, S., Smith, B. A., Fairchild, C. R., Aalbersberg, W., Hay, M. E., et al. (2010). Structure and biological evaluation of novel cytotoxic sterol glycosides from the marine red alga Peyssonnelia sp. Bioorganic & Medicinal Chemistry, 18(23), 8264-8269. Redshaw, C. H., Sutter, D., Myers, T. L., Naar, J., & Kubanek, J. (2010). Tracking losses of brevetoxins on exposure to phytoplankton competitors: Mechanistic insights. Aquatic Toxicology, 100(4), 365-372. Stout, E. P., Prudhomme, J., Le Roch, K., Fairchild, C. R., Franzblau, S. G., Aalbersberg, W., et al. (2010). Unusual antimalarial meroditerpenes from tropical red macroalgae. Bioorganic & Medicinal Chemistry Letters, 20(19), 5662-5665. Lane, A. L., Mular, L., Drenkard, E. J., Shearer, T. L., Engel, S., Fredericq, S., et al. (2010). Ecological leads for natural product discovery: novel sesquiterpene hydroquinones from the red macroalga Peyssonnelia sp. Tetrahedron, 66(2), 455-461. Stout, E. P., La Clair, J. J., Snell, T. W., Shearer, T. L., & Kubanek, J. (2010). Conservation of progesterone hormone function in invertebrate reproduction. Proceedings of the National Academy of Science U S A, 107(26), 11859-11864. Lin, A. S., Stout, E. P., Prudhomme, J., Le Roch, K., Fairchild, C. R., Franzblau, S. G., et al. (2010). Bioactive Bromophycolides R-U from the Fijian Red Alga Callophycus serratus. Journal of Natural Products, 73(2), 275-278. Whalen, K. E., Lane, A. L., Kubanek, J., & Hahn, M. E. (2010). Biochemical warfare on the reef: the role of glutathione transferases in consumer tolerance of dietary prostaglandins. PLoS One, 5(1), e8537. Prince, E. K., Poulson, K. L., Myers, T. L., Sieg, R. D., & Kubanek, J. (2010). Characterization of allelopathic compounds from the red tide dinoflagellate Karenia brevis. Harmful Algae, 10(1), 39-48. Lane, A. L., Nyadong, L., Galhena, A. S., Shearer, T. L., Stout, E. P., Parry, R. M., et al. (2009). Desorption electrospray ionization mass spectrometry reveals surface-mediated antifungal chemical defense of a tropical seaweed. Proceedings of the National Academy of Sciences of the United States of America, 106(18), 7314-7319. Poulson, K. L., Sieg, R. D., & Kubanek, J. (2009). Chemical ecology of the marine plankton. Natural Product Reports, 26(6), 729-745. Stout E. P., Hasemeyer A., Lane A. L., Davenport T., Engel S., Hay M. E., Fairchild C. R., Prudhomme J., Le Roch K., Aalbersberg W., Kubanek J. (2009) Antibacterial neurymenolides from the Fijian red alga Neurymenia fraxinifolia. Organic Letters, 11:225-228 Prince E. K., Myers T. L., Naar J., Kubanek J. (2008) Competing phytoplankton undermines allelopathy of a bloom-forming dinoflagellate. Proceedings of the Royal Society B: Biological Sciences, 275:2733-2741