Galan, Carmen - University of Bristol

个人简介

M. Carmen Galan received her B.S. degree in chemistry from Universidad de Alicante, Spain. She was awarded a Socrates-Erasmus grant to pursue an MPhil in Pure and Applied Chemistry at the University of Strathclyde, Glasgow, under the supervision of Prof. P.J. Hall and Dr. L.E.A. Berlouis. She received her Ph.D. in Organic Chemistry from the Complex Carbohydrate Research Center at The University of Georgia, USA, under the supervision of Prof. Geert-Jan Boons, where she carried out research in the field of carbohydrates. She then moved to California to pursue post-doctoral research with Prof. Chi-Huey Wong at The Scripps Research Institute. After that, she continued her post-doctoral training at Massachussetts Institute of Technology with Prof. Sarah O'Connor. Carmen returned to the UK in October 2006 on a lecturership in the School of Chemistry. In 2008 she became a Royal Society Dorothy Hodgkin fellow and from 2012-2017 she held a five year EPSRC Career Acceleration Fellowship. She currently holds and ERC consolidator award (from 2015) and since August 2017, the position of Professor in the School of Chemistry. CAREER SUMMARY 2017-now Professor, University of Bristol 2015-2017 Reader, University of Bristol 2012-date EPSRC Career Acceleration Fellow, University of Bristol 2013-2015 Senior Lecturer, University of Bristol 2012-2013 Lecturer, University of Bristol 2008-2012 Royal Society Dorothy Hodgkin Fellow, University of Bristol 2006-2008 Temporary Lecturer, University of Bristol 2005-2006 Post-Doctoral Fellow. Massachusetts Institute of Technology, Cambridge, USA 2003-2005 Post-Doctoral Research Associate. The Scripps Research Institute, La Jolla, CA, USA 1998-2002 PhD in Organic Chemistry. CCRC, The University of Georgia, Athens, USA 1997-1998 M.Phil. in Pure and Applied Chemistry. Strathclyde University 1992-1997 BSc in Chemistry. Universidad de Alicante AWARDS AND FELLOWSHIPS 7. 2017 RSC Carbohydrate Chemistry award sponshored by Dextra 6. European Research Council (ERC) Consolidator Investigator 2015 5. Visiting Professorship at Universite Joseph Fourier, Grenoble (France) 2012 4. Hoffmann-La Roche award to attend the European Young Investigator Workshop in Lyon 2011 3. EPSRC Career Acceleration Fellowship 2011 2. Royal Society Dorothy Hodgkin Fellowship 2008 1. Welcome Trust Value in People Award 2008

研究领域

OLIGOSACCHARIDE SYNTHESIS Access to structurally defined oligosaccharide libraries is key for the advancement of glycobiology research and also for carbohydrate-based drug discovery. We aim to develop general and efficient methodologies for the synthesis of oligosaccharide and glyco-conjugates of biological importance by addressing the key hurdles in oligosaccharide synthesis. FUNCTIONAL NANOMATERIALS We design and develop glycan-based fluorescent nano probes as a powerful tool to screen for carbohydrate-mediated interactions and exploit those for therapeutic and diagnostic applications in cancer, antimicrobials and plants. DRUG DISCOVERY The development of selective and potent anticancer therapeutics is one of the biggest challenges in the area of cancer research. G-quadruplexes are four-stranded guanine rich secondary DNA structures, which are over-represented in gene promoter regions including oncogenes and tumor suppressors. We aim to develop ligands able to stabilised selective G-quadruplex structures as novel anti-cancer therapeutics.

近期论文

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M. P. O’Hagan, S. Haldar, J. C. Morales, A. J. Mulholland* and M. C. Galan* "Enhanced sampling molecular dynamics simulations correctly predict the diverse activities of a series of stiff-stilbene G-quadruplex DNA ligands" Chem. Sci., 2021, ASAP DOI: 10.1039/D0SC05223J S. Richards, T. Keenan, J-B. Vendeville, D. E. Wheatley, H. Chidwick, D. Budhadev, C. E. Council,C. S. Webster, H. Ledru, A. N. Baker, M. Walker,M. C Galan, B. Linclau, M. A. Fascione and M. I. Gibson "Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands" Chem. Sci., 2021, ASAP DOI: 10.1039/D0SC05360K. D. E. Wise, A. J. Gamble, S. W. Arkawazi, P. H. Walton, M. C. Galan, M. P. O'Hagan, K. G. Hogg, J. L. Marrison, P. J. O'Toole, H. A. Sparkes, J. M. Lynam and P. G. Pringle "Cytotoxic (cis,cis-1,3,5-triaminocyclohexane) ruthenium(II)-diphosphine complexes; evidence for covalent binding and intercalation with DNA" Dalton Trans., 2020, 49, 15219-15230. DOI: 10.1039/D0SC05360K. R. A. Jeanneret, S. E. Johnson and M. C Galan* "Conformationally Constrained Glycosyl Donors as Tools to Control Glycosylation Outcomes" J. Org. Chem., 2020, 85, Pages TBC. DOI/10.1021/ACS.JOC.0C02045 R. A. Jeanneret and M. C. Galan*, "Ionic Liquid Tags for Supported Oligosaccharide Synthesis" Reference Module in Chemistry, Molecular Sciences and Chemical Engineering 2020 DOI:10.1016/B978-0-12-819475-1.00014-6 S.S.E. Michel, S. E. Rogers, W. Briscoe* And M. C. Galan* "Tuneable Thiol-Ene Photo-Crosslinked Chitosan-Based Hydrogels for Biomedical Applications" ACS Appl. Bio. Mat., 2020, 3, 11, 8075–8083. DOI:10.1021/acsabm.0c01171 Preprint: (2020) ChemRxiv DOI:10.26434/chemrxiv.12924686.v1 A. J. Fairbanks*, Sabine L. Flitsch*, M. C. Galan* "Introduction to Glycosylation: new methodologies and applications". Org. Biomol. Chem., 2020, 18, 6979-6982. DOI: 10.1039/D0OB90110E T. A. Swift, D. Fagan, D. Benito-Alifonso, S. A. Hill, M. L. Yallop, T. A. A. Oliver, T. Lawson, M. C. Galan*, H. M. Whitney* "Photosynthesis and crop productivity is enhanced by glucose-functionalized fluorescent carbon dots" New Phytologist , 2020, 29, 783–790. Accepted.DOI:10.1111/nph.16886, Preprint: (2019) BioRxiv DOI: 10.1101/82662 E. Flack, H. Chidwick, G. Guchhait, T. Keenan, D. Budhadev, K. Huang, P. Both, J. Mas Pons, H. Ledru, S. Rui, G. Stafford, J. Shaw, M. C. Galan, S. Flitsch, G.Thomas, M. Fascione* "Biocatalytic Transfer of Pseudaminic Acid (Pse5Ac7Ac) using Promiscuous Sialyltransferases in a Chemoenzymatic Approach to Pse5Ac7Ac Containing Glycosides" ACS Catal., 2020, 10, 17, 9986–9993. DOI:10.1021/acscatal.0c02189 S.S.E. Michel, A. Kilner, J.-C. Eloi, S. E. Rogers, W. Briscoe* and M. C. Galan* "Norbornene-Functionalised Chitosan Hydrogels and Microgels via an Unprecedented Photo-Initiated Self- Assembly for Potential Biomedical Applications" ACS Appl. Bio. Mat., 2020, 3, (8), 5253–5262. DOI:10.1021/acsabm.0c00629 Preprint: (2020) ChemRxiv DOI: 10.26434/chemrxiv.12340484.v1 P. Valverde, J.-B. Vendeville, K. Hollingsworth, A. Mattey, T. Keenan, H. Chidwick, H. Ledru, K. Huonnic, K. Huang, M. Light, N. Turner, J. Jimenez-Barbero, M. C. Galan, M. A. Fascione, S. Flitsch,* W. B. Turnbull,* and B. Linclau,* "Chemoenzymatic synthesis of 3-deoxy-3-fluoro-L-fucose and its enzymatic incorporation into glycoconjugates" Chem. Commun., 2020, 56, 6408-6411. DOI: 10.1039/D0CC02209H V. Levario-Diaz, P. Bhaskar M. C. Galan* and A. Barnes. "Effect of acoustic standing waves on cellular viability and metabolic activity" Scientific Reports (2020) 10(1):8493 DOI: 10.1038/s41598-020-65241-4 G. S. Bulmer, A. P. Mattey, F. Parmeggiani, R. Williams, H. Ledru, A. Marchesi, L. S. Seibt, P. Both, K. Huang, M. C. Galan, S. L. Flitsch, A. P. Green, J. M. van Munster. "In vitro biosynthesis of poly-β-1,4-glucan derivatives using a pro-miscuous glycosyltransferase" Preprint: (2020) BioRxiv DOI:10.1101/2020.02.14.949545 S. T. G. Street, P. Peñalver, G.J. Hollingworth, M. P. O'Hagan, J. C. Morales* and M. C. Galan* "Imide Condensation as a Strategy for the Synthesis of Core Diversified G-Quadruplex Ligands with Anti-Cancer and Anti-Parasitic Activity" Preprint: (2020) ChemRxiv. DOI: 10.26434/chemrxiv.11955870.v1 I. Herrera-Gonzalez, E. M. Sanchez-Fernandez, A. Sau, C. Native, J. M. Garcia Fernandez, M. C. Galan* and C. Ortiz Mellet* "Stereoselective Synthesis of Iminosugar 2-Deoxy(thio)glycosides from Bicyclic Iminoglycal Carbamates Promoted by Cerium(IV) Ammonium Nitrate and Cooperative Brønsted Acid-Type Organocatalysis" J. Org. Chem., 2020, 85, 7, 5038-5047. DOI: 10.1021/acs.joc.0c00324 K. Huang, A. Marchesi, K. Hollingsworth, P. Both, A. P. Mattey, E. Pallister, H. Ledru, S. Charnock, M. C. Galan, W. B.Turnbull, F. Parmeggiani* and S. L. Flitsch* "Biochemical characterisation of an α1,4 galactosyltransferase from Neisseria weaveri for the synthesis of α1,4-linked galactosides" Org. Biomol. Chem., 2020, 18, 3142 - 3148. DOI:10.1039/D0OB00407C M. P. O'Hagan, J. Ramos-Soriano, S. Haldar, S. Sheik, A. J. Mulholland, J.C. Morales and M. Carmen Galan*" Visible-light photoswitching of ligand binding mode suggests G-quadruplex DNA as a target for photopharmacology" Chem. Commun., 2020, 56, 5186 - 5189. DOI:10.1039/D0CC01581D A. Henderson, J. Bower*, and M. C. Galan* "Pseudo-Enantiomeric Carbohydrate-Based N-Heterocyclic Carbenes as Promising Chiral Ligands for Enantiotopic Discrimination" Org. Biomol. Chem., 2020, 18, 3012 - 3016. DOI:10.1039/D0OB00155D M. Ghirardello, H. Ledru, A. Sau and M. C. Galan*"Chemo-selective Rh-catalysed hydrogenation of azides into amines" Carbohydr. Res., 2020, 489, 107948.DOI:10.1016/j.carres.2020.107948 M. P. O'Hagan, P. Peñalver, R. S. L. Gibson J. C. Morales*, M. C. Galan* "Stiff-stilbene ligands target G-quadruplex DNA and exhibit selective anticancer and antiparasitic activity" Chem. Eur. J., 2020, 26, 6244 - 6233. DOI:10.1002/chem.201905753 Preprint: (2019) ChemRxiv. DOI:10.26434/chemrxiv.11413122.v1