Orchard, Clive - University of Bristol - School of Physiology, Pharmacology and Neuroscience

研究领域

Regulation of cardiac-contraction coupling

近期论文

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Du, C, El Harchi, A, Zhang, Y, Orchard, C & Hancox, J, 2011, ‘Pharmacological Inhibition of the hERG Potassium Channel Is Modulated by Extracellular But Not Intracellular Acidosis’. J Cardiovasc Electrophysiol., pp. in press Chase, A & Orchard, C, 2010, ‘Ca efflux via the sarcolemmal Ca ATPase occurs only in the t-tubules of rat ventricular myocytes’. Journal of Molecular and Cellular Cardiology, vol 50., pp. 187 - 193 Du, C, El Harchi, A, McPate, M, Orchard, C & Hancox, J, 2011, ‘Enhanced inhibitory effect of acidosis on hERG potassium channels that incorporate the hERG1b isoform’. Biochem Biophys Res Comm, vol 405., pp. 222 - 227 Orchard, C, Brette, F, Chase, A & Fowler, M, 2011, ‘Role of the t-tubules in the response of cardiac ventricular myocytes to inotropic interventions’. in: U Ravens, M Sanguinetti, O Tripathi (eds) Heart Rate & Rhythm. Springer Cheng, H, Li, J, James, AF, Inada, S, Choisy, SCM, Orchard, CH, Zhang, H, Boyett, MR & Hancox, JC, 2016, ‘Characterization and influence of cardiac background sodium current in the atrioventricular node’. Journal of Molecular and Cellular Cardiology, vol 97., pp. 114-124 Zhang, H, Cannell, MB, Kim, SJ, Watson, JJ, Norman, R, Calaghan, SC, Orchard, C & James, AF, 2015, ‘Cellular Hypertrophy and Increased Susceptibility to Spontaneous Calcium-Release of Rat Left Atrial Myocytes Due to Elevated Afterload’. PLoS ONE, vol 10. Choisy, SC, Cheng, H, Orchard, CH, James, AF & Hancox, JC, 2015, ‘Electrophysiological properties of myocytes isolated from the mouse atrioventricular node: L-type ICa, IKr, If, and Na-Ca exchange’. Physiological reports, vol 3. Gadeberg, HC, Bryant, SM, James, AF & Orchard, CH, 2015, ‘Altered Na/Ca exchange distribution and activity in ventricular myocytes from failing hearts’. AJP- Heart and Circulatory Phisiology, vol 310., pp. H262-H268 Avolio, E, Rodriguez-Arabaolaza, I, Spencer, HL, Riu, F, Mangialardi, G, Slater, SC, Rowlinson, J, Alvino, VV, Idowu, OO, Soyombo, S, Oikawa, A, Swim, MM, Kong, CHT, Cheng, H, Jia, H, Ghorbel, MT, Hancox, JC, Orchard, CH, Angelini, G, Emanueli, C, Caputo, M & Madeddu, P, 2015, ‘Expansion and Characterization of Neonatal Cardiac Pericytes Provides a Novel Cellular Option for Tissue Engineering in Congenital Heart Disease’. Journal of the American Heart Association, vol 4. Bryant, SM, Kong, CHT, Watson, J, Cannell, MB, James, AF & Orchard, CH, 2015, ‘Altered distribution of ICa impairs Ca release at the t-tubules of ventricular myocytes from failing hearts’. Journal of Molecular and Cellular Cardiology, vol 86., pp. 23?31