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G protein-coupled receptor function and signalling in atherothrombosis

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Aungraheeta, R, Conibear, A, Butler, M, Kelly, E, Nylander, S, Mumford, A & Mundell, S, 2016, ‘Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor’. Blood. Metcalfe, C, Ramasubramoni, A, Pula, G, Harper, MT, Mundell, SJ & Coxon, CH, 2016, ‘Thioredoxin Inhibitors Attenuate Platelet Function and Thrombus Formation’. PloS one, vol 11., pp. e0163006 Norman, JE, Cunningham, MR, Jones, ML, Walker, ME, Westbury, SK, Sessions, RB, Mundell, SJ & Mumford, AD, 2016, ‘Protease-Activated Receptor 4 Variant p.Tyr157Cys Reduces Platelet Functional Responses and Alters Receptor Trafficking’. Arteriosclerosis, Thrombosis and Vascular Biology, vol 36., pp. 952-960 Nisar, SP, Jones, ML, Cunningham, MR, Mumford, AD, Mundell, SJ & , 2015, ‘Rare platelet GPCR variants: what can we learn?’. British Journal of Pharmacology, vol 172., pp. 3242-53 Johnson, TW, Mumford, AD, Scott, LJ, Mundell, S, Butler, M, Strange, JW, Rogers, CA, Reeves, BC & Baumbach, A, 2015, ‘A Study of Platelet Inhibition, Using a 'Point of Care' Platelet Function Test, following Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction [PINPOINT-PPCI]’. PloS one, vol 10., pp. e0144984 Norman, JE, Lee, KR, Walker, ME, Murden, SL, Harris, J, Mundell, S, Murphy, GJ & Mumford, AD, 2015, ‘Low multiple electrode aggregometry platelet responses are not associated with non-synonymous variants in G-protein coupled receptor genes’. Thrombosis Research. Patel, YM, Lordkipanidzé, M, Lowe, GC, Nisar, SP, Garner, K, Stockley, J, Daly, ME, Mitchell, M, Watson, SP, Austin, SK & Mundell, SJ, 2014, ‘A novel mutation in the p2y12 receptor and a function-reducing polymorphism in par-1 in a patient with chronic bleeding’. Journal of Thrombosis and Haemostasis, vol 12., pp. 716-725 Lordkipanidzé, M, Lowe, GC, Kirkby, NS, Chan, MV, Lundberg, MH, Morgan, NV, Bem, D, Nisar, SP, Leo, VC, Jones, ML, Mundell, SJ, Daly, ME, Mumford, AD, Warner, TD & Watson, SP, 2014, ‘Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay’. Blood Reviews. Kelly, E, Mundell, SJ, Sava, A, Roth, AL, Felici, A, Maltby, K, Nathan, PJ, Bullmore, ET & Henderson, G, 2014, ‘The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours’. Psychopharmacology. Johnson, TW, Marsden, D, Mumford, A, Pike, K, Mundell, S, Butler, M, Strange, JW, Bowles, R, Rogers, CA, Baumbach, A & Reeves, BC, 2014, ‘Point of care platelet activity measurement in primary PCI [PINPOINT-PPCI]: a protocol paper’. BMC cardiovascular disorders, vol 14., pp. 44

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