Jane, David - University of Bristol - School of Physiology, Pharmacology and Neuroscience

研究领域

Development of pharmacological tools for glutamate receptors

近期论文

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Alushin, G, Jane, D & Mayer, M, 2011, ‘Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists’. Neuropharmacology, vol 60., pp. 126 - 134 Lennon, S, Rivero, G, Matharu, A, Howson, P, Jane, D, Roberts, P & Kelly, E, 2010, ‘Metabotropic glutamate receptor mGlu2 is resistant to homologous agonist-induced desensitization but undergoes protein kinase C-mediated heterologous desensitization’. European Journal of Pharmacology, vol 649., pp. 29 - 37 Weatherall, K, Goodchild, S, Jane, D & Marrion, N, 2010, ‘Small conductance calcium-activated potassium channels: from structure to function’. Progress in Neurobiology, vol 91., pp. 242 - 255 Atlason, P, Scholefield, C, Eaves, R, Mayo-Martin, M, Jane, D & Molnar, E, 2010, ‘Mapping the Ligand Binding Sites of Kainate Receptors: Molecular Determinants of Subunit-selective Binding of the Antagonist [3H]UBP310’. Molecular Pharmacology, vol 78., pp. 1036 - 1045 Suárez, F, Zhao, Q, Monaghan, D, Jane, D, Jones, S & Gibb, A, 2010, ‘Functional heterogeneity of NMDA receptors in rat substantia nigra pars compacta and reticulate neurones’. European Journal of Neuroscience, vol 32., pp. 359 - 367 France, G, Fernández-Fernández, D, Burnell, ES, Irvine, MW, Monaghan, DT, Jane, DE, Bortolotto, ZA, Collingridge, GL & Volianskis, A, 2016, ‘Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus’. Neuropharmacology. Shoemark, DK, Williams, C, Fahey, MS, Watson, JJ, Tyler, SJ, Scoltock, SJ, Ellis, R, Wickendon, E, Burton, AJ, Hemmings, JLL, Bailey, CD, Dawbarn, D, Jane, DE, Willis, CL, Sessions, RB, Allen, SJ & Crump, MP, 2015, ‘Design and nuclear magnetic resonance (NMR) structure determination of the second extracellular immunoglobulin tyrosine kinase A (TrkAIg2) domain construct for binding site elucidation in drug discovery’. Journal of Medicinal Chemistry, vol 58., pp. 767-777 Irvine, MW, Fang, G, Eaves, R, Mayo-Martin, MB, Burnell, ES, Costa, BM, Culley, GR, Volianskis, A, Collingridge, GL, Monaghan, DT & Jane, DE, 2014, ‘Synthesis of a series of novel 3,9-disubstituted phenanthrenes as analogues of known N-methyl-D-aspartate receptor allosteric modulators’. Synthesis, vol 47., pp. 1593-1610 Park, P, Volianskis, A, Sanderson, TM, Bortolotto, ZA, Jane, DE, Zhuo, M, Kaang, B-K & Collingridge, GL, 2014, ‘NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation’. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, vol 369., pp. 20130131 Volianskis, A, Bannister, NJ, Collett, VJ, Irvine, MW, Monaghan, D, Fitzjohn, SM, Jensen, MS, Jane, DE & Collingridge, GL, 2013, ‘Different NMDA receptor subtypes mediate induction of long-term potentiation and two forms of short-term potentiation at CA1 synapses in rat hippocampus in vitro.’. J Physiol, vol 591., pp. 955-972