Hers, Ingeborg - University of Bristol - School of Physiology, Pharmacology and Neuroscience

研究领域

Regulation of platelet signalling and activation

近期论文

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Moore, SF, Williams, CM, Brown, E, Blair, TA, Harper, MT, Coward, RJ, Poole, AW & Hers, I, 2015, ‘Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling’. Cardiovascular research. Moore, SF, Hunter, RW & Hers, I, 2014, ‘Protein kinase C and P2Y12 take center stage in thrombin-mediated activation of mammalian target of rapamycin complex 1 in human platelets’. Journal of Thrombosis and Haemostasis, vol 12., pp. 748-60 van den Bosch, MTJ, Poole, AW & Hers, I, 2014, ‘Cytohesin-2 phosphorylation by protein kinase C relieves the constitutive suppression of platelet dense granule secretion by ADP-ribosylation factor 6’. Journal of Thrombosis and Haemostasis, vol 12., pp. 726-35 Moore, SF, Hunter, RW, Harper, MT, Savage, JS, Siddiq, S, Westbury, SK, Poole, AW, Mumford, AD & Hers, I, 2012, ‘Dysfunction of the PI3 kinase/Rap1/integrin αIIbβ3 pathway underlies ex vivo platelet hypoactivity in essential thrombocythemia’. BLOOD, vol 121., pp. 1209-19 Moore, SF, van den Bosch, MTJ, Hunter, RW, Sakamoto, K, Poole, AW & Hers, I, 2013, ‘Dual Regulation of Glycogen Synthase Kinase 3 (GSK3)alpha/beta by Protein Kinase C (PKC)alpha and Akt Promotes Thrombin-mediated Integrin alpha(IIb)beta(3) Activation and Granule Secretion in Platelets’. The Journal of Biological Chemistry, vol 288., pp. 3918-3928 Chen, MZ, Hudson, CA, Vincent, EE, De Berker, DAR, May, MT, Hers, I, Dayan, CM, Andrews, RC & Tavare, JM, 2015, ‘Bariatric surgery in morbidly obese insulin resistant humans normalises insulin signalling but not insulin-stimulated glucose disposal’. PLoS ONE, vol 10. Williams, C, Savage, J, Harper, M, Moore, S, Hers, I & Poole, A, 2015, ‘Identification of roles for the SNARE-associated protein, SNAP29, in mouse platelets’. Platelets. Moore, S, Hers, I & Blair, T, 2015, ‘Circulating primers enhance platelet function and induce resistance to antiplatelet therapy.’. Journal of Thrombosis and Haemostasis. Harper, MT, van den Bosch, MT, Hers, I & Poole, AW, 2015, ‘Platelet dense granule secretion defects may obscure α-granule secretion mechanisms: evidence from Munc13-4-deficient platelets’. Blood, vol 125., pp. 3034-6 Agbani, E, Van den Bosch, M, Brown, E, Williams, C, Mattheij, N, Cosemans, JMEM, Collins, P, Heemskerk, JWM, Hers, I & Poole, A, 2015, ‘Coordinated membrane ballooning and procoagulant-spreading in human platelets: Ballooned and procoagulant-spread platelets’. Circulation.