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Petherick, K.J., Williams, A.C., Lane, J.D., Ordó?ez-Morán, P., Huelsken, J., Smartt, H.J.M., Batson, J., Paraskeva, C. and Greenhough, A. (2013) A regulatory axis integrates Wnt/β-catenin-mediated suppression of autophagy and p62 expression with autophagic degradation of β-catenin. EMBO J. [Epub ahead of print] Al-Kharusi, M., Smartt, H.J.M., Greenhough, A., Collard, T.J., Emery, E., Williams, A.C. and Paraskeva, C. (2013) Lgr5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs. Carcinogenesis [Epub ahead of print] Skeen, V.R., Collard, T.J., Southern, S.L., Greenhough, A., Hague, A., Townsend, P.A., Paraskeva, C. and Williams, A.C. (2012) BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor beta [TGF-β1] in colorectal tumour cells. Oncogene [Epub ahead of print]. Skeen, V.R., Paterson, I., Paraskeva, C. and Williams, A.C. (2012) TGF-β1 Signalling, Connecting aberrant inflammation and colorectal tumorigenesis. Curr. Pharm. Des. 18(26): 3874-3888. Collard, T.J, Clemo, N.K., Urban, B., Hague, A., Townsend, P.A., Paraskeva, C. and Williams, A.C. (2012) The retinoblastoma protein (Rb) as an anti-apoptotic factor: expression of Rb is required for the anti-apoptotic function of BAG-1 protein in colorectal tumour cells. Cell Death and Disease. 2012 [Epub ahead of print] Smartt, H.J., Greenhough, A., Ordó?ez-Morán, P., Al-Kharusi, M., Collard, T.J., Mariadason, J.M., Huelsken, J., Williams, A.C. and Paraskeva, C.(2012) β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin? Br. J. Cancer 107(9), 1514-1517. Southern, S.L., Collard, T.J., Urban, B.C., Skeen, V.R., Smartt, H.J., Hague, A., Oakley, F., Townsend, P.A., Perkins, N.D., Paraskeva, C. and Williams, A.C. (2012) BAG-1 interacts with the p50-p50 homodimeric NF-κB complex: implications for colorectal carcinogenesis. Oncogene 31(22), 2761-2772. Smart, H.J., Greenhough, A., Ordó?ez-Morán, P., Talero, E., Cherry, C.A., Wallam, C.A., Parry, L., Al Kharusi, M., Roberts, H.R., Mariadason, J.M., Clarke, A.R., Huelsken, J., Williams, A.C. and Paraskeva, C. (2011) β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells. Gut 61(9),1306-1314. Robinson, K.S., Clements, A., Williams, A.C., Berger, C.N. and Frankel, G. (2011) Bax Inhibitor 1 in apoptosis and disease. Oncogene 30(21), 2391-4000. Roberts, H.R., Smartt, H.J., Greenhough, A., Moore, A.E., Williams, A.C., Paraskeva, C. (2011) Colon tumour cells increase PGE(2) by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation. Carcinogenesis 32(11), 1741-1747. Greenhough, A., Wallam, C.A., Hicks, D.J., Moorghen, M., Williams, A.C. and Paraskeva, C. (2010) The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE(2) signalling in colorectal adenoma cells. Oncogene. 29, 3398-410. Patsos, H.A., Greenhough, A., Hicks, D.J., Al Kharusi, M., Collard, T.J., Lane, J.D., Paraskeva, C. and Williams, A.C. (2010) The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells. Int. J. Oncol. 37, 187-93. Moore, A.E., Greenhough, A., Roberts, H.R., Hicks, D.J., Patsos, H.A., Williams, A.C. and Paraskeva, C. (2009) HGF/Met signalling promotes PGE2 biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells. Carcinogenesis. 30,1796-1804. Greenhough, A., Smartt, H.J., Moore, A.E., Roberts, H.R., Williams, A.C., Paraskeva, C. and Kaidi, A. (2009) The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis 30(3), 377-86. Clemo, N.K., Collard, T.J., Southern, S., Edwards, K.D., Moorghen, M., Packham, G., Hague, A., Paraskeva, C. and Williams, A.C. (2008) BAG-1 is upregulated in colorectal tumour progression and promotes tumour cell survival through increased NF-kappaB activity. Carcinogenesis 29, 849-857.