近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Mojica, M.F., Mahler, S.G., Bethel, C.R., Taracila, M.A., Kosmopoulou, M., Papp-Wallace, K.M., Llarrull, L.I., Wilson, B.M., Marshall, S.H., Wallace, C.J., Villegas, M.V., Harris, M.E., Vila, A.J., Spencer, J. and Bonomo, R.A. (2015) Exploring the role of residue 228 in substrate and inhibitor recognition by VIM metallo-β-lactamases. Biochemistry 54, 3183-3196. Chudyk, E.I., Limb, M.A., Jones, C., Spencer, J., van der Kamp, M.W. and Mulholland, A.J. (2014) QM/MM simulations as an assay for carbapenemase activity in class A β-lactamases. Chem. Commun. (Camb) 50, 14736-9. Brem, J., van Berkel, S.S., Aik, W., Rydzik, A.M., Avison, M.B., Pettinati, I., Umland, K.D., Kawamura, A., Spencer, J., Claridge, T.D., McDonough, M.A. and Schofield, C.J. (2014) Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition. Nat. Chem. 6, 1084-90. Challand, M.R., Salvadori, E., Driesener, R.C., Kay, C.W., Roach, P.L., and Spencer, J. (2013) Cysteine methylation controls radical generation in the Cfr radical AdoMet rRNA methyltransferase. PLOS ONE 8, e67979. Fonseca, F., Chudyk, E.I., van der Kamp, M.W., Correia, A., Mulholland, A.J., and Spencer, J. (2012) The basis for carbapenem hydrolysis by class A β-lactamases: a combined investigation using crystallography and simulations. J. Am. Chem. Soc. 134, 18275. Fonseca, F., Bromley, E.H.C., Saavedra, M.-J., Correia, A. and Spencer J. (2011) Crystal structure of Serratia fonticola Sfh-I: Activation of the nucleophile in mono-zinc Metallo-b-Lactamases. J. Mol. Biol. 411, 951. Xiong, X., Bromley, E.H., Oelschlaeger, P., Woolfson, D.N., Spencer, J. (2011) Structural insights into quinolone antibiotic resistance mediated by pentapeptide repeat proteins: conserved surface loops direct the activity of a Qnr protein from a Gram-negative bacterium. Nucleic Acids Res., Nucleic Acids Res. 39, 3917.