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Skeen,V.R., Collard, T.J., Southern, S. L., Greenhough, A., Hague, A., Townsend, P., Paraskeva, C. and Williams, A.C. (2013) BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor ? (TGF-?1) in colorectal tumour cells. Oncogene 32(38), 4490-4499. Petherick, K.J., Williams, A.C., Lane, J.D., Ordonez-Moran, P., Huelsken, J., Collard, T.J., Smartt, H.J., Batson, J., Malik, K., Paraskeva, C. and Greenhough, A. (2013) Autolysosomal β-catenin degradation regulates Wnt-autophagy-p62 crosstalk. The EMBO Journal 32(13), 1903-1916. Al-Kharusi, M.R.A,. Smart, H.J.M., Greenhough, A., Collard, T.J., Emery, E.D., Williams, A.C. and Paraskeva, C. (2013) LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: Implications for targeting adenoma stem cells with NSAIDs. Carconogenisis 34, 1150-1157. Smartt, H.J.M., Greenhough, A., Ordonez-Moran, P., Talero, E., Wallam, C.J., Parry, L., Al-Kharusi, M., Roberts, H.R., Mariadason, J.M., Clarke, A.R., Huelsken, J., Williams, A.C. and Paraskeva, C. (2011) B-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells. Gut 61, 1306-1314. Roberts, H.R., Smartt, H.J.M., Greenhough, A., Moore, A.E., Williams, A.C. and Paraskeva, C. (2011) Colon tumour cells increase PGE2 by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation. Carcinogenesis 32(11), 1741-1747. Greenhough, A., Wallam, C.A., Hicks, D.J., Moorghen, M., Williams, C.C. and Paraskeva, C. (2010) The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE(2) signalling in colorectal adenoma cells. Oncogene 29, 3398-3410. Greenhough, A., Smartt, H.J., Moore, A.E., Roberts, H.R., Williams, A.C., Paraskeva, C. and Kaidi, A. (2009) The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis 30(3), 377-386. Moore, A.E., Greenhough, A., Roberts, H.R., Hicks, D.J., Patsos, H.A., Williams, A.C. and Paraskeva, C. (2009) HGF/Met signaling promotes PGE2 Biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells. Carcinogenesis 30, 1796-1804. Clemo, N.K., Collard, T.J., Southern, S., Edwards, K.D., Moorghen, M., Packham, G., Hague, A., Paraskeva, C. and Williams, A.C. (2008) BAG-1 is upregulated in colorectal tumour progression and promotes tumour cell survival through increasd NF-kappaB activity. Carcinogenesis 29, 849-857. Kaidi, A., Williams, A.C., and Paraskeva, C. (2007) Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia. Nat. Cell Biol.9(2), 210-217.