Matthews, David - University of Bristol - School of Cellular and Molecular Medicine

研究领域

I am primarily interested in virus host cell interactions with an emphasis on respiratory viruses, in particular adenovirus, but also respiratory syncytial virus, influenza and Hendra virus.

近期论文

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Dowall, S.D., Matthews, D.A., García-Dorival, I., Taylor, I., Kenny, J., Hertz-Fowler, C., Hall, N., Corbin-Lickfett, K., Empig, C., Schlunegger, K., Barr, J.N., Carroll, M.W., Hewson, R. and Hiscox, J.A. (2014) Elucidating variations in the nucleotide sequence of Ebola virus associated with increasing pathogenicity. Genome Biology 15, 540. García-Dorival, I., Wu, W., Dowall, S., Armstrong, S., Touzelet, O., Wastling, J., Barr, J.N., Matthews, D., Carroll, M., Hewson, R., and Hiscox, J.A. (2014) Elucidation of the Ebola virus VP24 cellular interactome and disruption of virus biology through targeted inhibition of host cell protein function. J. Proteome. Res. 13, 5120-5135. Wynne, J.W., Shiell, B.J., Marsh, G.A., Boyd, V., Harper, J., Heesom, K., Monaghan, P., Zhou, P., Payne, J., Klein, R., Todd, S., Mok, L., Green, D., Bingham, J., Tachedjian, M., Baker, M.L., Matthews, D.A. and Wang, L-F. (2014) Proteomics informed by transcriptomics reveals Hendra virus sensitizes bat cells to TRAIL mediated apoptosis. Genome Biology 15, 532. Chiu, H.C., Hannemann, H., Heesom, K.J., Matthews, D.A. and Davidson, A.D. (2014) High-throughput quantitative proteomic analysis of dengue virus type 2 infected a549 cells. PLoS One 9, e93305. Evans, V.C., Barker, G., Heesom, K.J., Fan, J., Bessant, C., Matthews, D.A. (2012) De novo derivation of proteomes from transcriptomes for transcript and protein identification. Nature Methods 9, 1207-1211. Wu, W., Tran, K.C., Teng, M.N., Heesom, K.J., Matthews, D.A., Barr, J.N. and Hiscox, J.A. (2012). Solution of the human respiratory syncytial virus NS1 protein interactome highlights multiple effects on host cell biology. J. Virol. 86, 7777 – 7789. Lam, Y.W., Evans, V.C., Heesom, K.J., Lamond, A.I. and Matthews, D.A. (2010) Proteomic analysis of the nucleolus in adenovirus infected cells. Mol. Cell. Proteomics, 9, 117-130. Highlighted in that months edition. Emmott, E., Wise, H., Loucaides, E.M., Matthews, D.A., Digard, P. and Hiscox, J. (2010) Quantitative proteomics using SILAC coupled to LC-MS/MS reveals changes in the nucleolar proteome in influenza virus infected cells. J. Proteome Research, 9, 5335-5345.