Brown, Keith - University of Bristol - School of Cellular and Molecular Medicine

研究领域

My research interests are in the molecular genetics of cancer, concentrating in particular on epigenetic changes in childhood cancers and in cancer stem cells

近期论文

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Charlet, J., Szemes, M., Malik, K.T.A. and Brown, K.W. (2014) MYCN is Recruited to the RASSF1A Promoter but is not critical for DNA Hypermethylation in Neuroblastoma. Molecular Carcinogenesis, 53, 413-420. Szemes, M., Dallosso, A.R., Melegh, Z., Curry, T., Li, Y., Rivers, C., Uney, J., M?gdefrau, A-S., Schwiderski, K., Brown, K.W., Shandilya, J., Roberts, S. and Malik, K. (2013) Modulation of epigenetic states by Wilms' tumor 1 via regulation of de novo DNA methyltransferase 3A. Human Molecular Genetics, 22, 74-83. Charlet, J., Schnekenburger, M., Brown, K.W. and Diederich, M. (2012) DNA demethylation increases sensitivity of neuroblastoma cells to chemotherapeutic drugs. Biochemical Pharmacology, 83, 858-865. Brown, K.W., Charles, A., Dallosso, A., White, G., Charlet, J., Standen, G.R. and Malik, K. (2012) Characterization of 17.94, a novel anaplastic Wilms' tumor cell line. Cancer Genetics, 205, 319-326. Dallosso, A.R., Hancock, A.L., Szemes, M., Moorwood, K., Chilukamarri, L., Tsai, H.H., Sarkar, A., Barasch, J., Vuononvirta, R., Jones, C., Pritchard-Jones, K., Royer-Pokora, B., Lee, S.B., Owen, C., Malik, S., Feng, Y., Frank, M., Ward, A., Brown, K.W. and Malik, K. (2009) Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' Tumor. PLoS Genetics 5, e1000745. Vuononvirta, R., Sebire, N.J., Dallosso, A.R., Reis-Filho, J.S., Williams, R.D., Mackay, A., Fenwick, K., Grigoriadis, A., Ashworth, A., Pritchard-Jones, K., Brown, K.W., Vujanic, G.M. and Jones, C. (2008) Mapping the molecular alterations in IGF2-associated Wilms tumorigenesis – perilobar nephrogenic rests as non-obligate molecular genetic precursor lesions. Clin. Cancer Res. 14, 7635-7644. Brown, K.W., Power, F., Moore, B., Charles, A.K. and Malik, K.T.A. (2008) Frequency and timing of loss of imprinting at 11p13 and 11p15 in Wilms' Tumor development. Mol. Cancer Res. 6, 1114-1123.