Blocker, Ariel - University of Bristol - School of Cellular and Molecular Medicine

研究领域

Structural and functional analysis of the type III secreton of Shigella flexneri Mechanisms of protein targeting and secretion in prokaryotes Mechanisms of cell surface appendage assembly in Gram-negative bacteria Bacterial Pathogenesis Cellular Microbiology Macromolecular structures Biochemistry, Molecular Genetics and Electron Microscopy

近期论文

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Cheung, M., Shen, D.-K., Makino, F., Kato, T., Roehrich, A.D., Martinez-Argudo, I., Walker, M.L., Murillo, I., Lui, X., Pain, M., Brown, J., Frazer, G., Mantell, J., Mina, P., Todd, T., Sessions, R.B., *Namba, K. and *Blocker, A.J. (2014) Three-dimensional electron microscopy reconstruction and cysteine-mediated crosslinking provide a model of the T3SS needle tip complex. Mol. Microbiol., doi:10.1111/mmi.12843. *Joint corresponding authors. Martinez-Argudo, I., Veenendaal, A.K.J., Liu, X., Roehrich, A.D., Franzoni, G., van Rietschoten, K.N., Morimoto, Y.V., Saijo-Hamano, Y., Avison, M.B., Studholme, D.J., Namba, K., Minamino, T. and Blocker, A.J. (2013) Isolation of Salmonella enterica sv. Typhimurium mutants resistant to the inhibitory effect of salicylidene acylhydrazides on flagella-mediated motility. PLoS One 8(1), e52179. doi:10.1371/journal.pone.0052179. Roehrich, A.D., Guillossou, E., Blocker*, A.J. and Martinez-Argudo, I. (2013) Shigella IpaD has a dual role: signal transduction from the T3SS needle tip and intracellular secretion regulation. Mol. Micro. 87, 690-706. *Corresponding author. Fujii, T., Cheung, M., Blanco, A., Kato, T., Blocker*, A.J. and Namba*, K. (2012) The structure of a type III secretion needle at 7? resolution provides insights into its assembly and signaling mechanisms. Proc. Natl. Acad. Sci. USA. 109, 4461-4466.*Joint corresponding authors. Martinez-Argudo, I. and Blocker, A.J. (2010) The Shigella T3SS needle transmits a signal for MxiC release, which controls secretion of effectors. Mol. Microbiol. 78, 1365–1378. N.B.: This article was the subject of a ‘Research Highlight’ piece by Dr. Sheilagh Molloy, Senior Editor at Nature Reviews Microbiology (2010) 8, 840. Hodgkinson, J.L., Horsley, A., Stabat, D., Simon, M., Johnson, S., da Fonseca, P.C.A, Morris, E.P., Wall, J.S., Lea, S.M. and Blocker, A.J. (2009) 3D reconstruction of the Shigella flexneri T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout. Nat. Struct. Mol. Biol. 16, 477-485. Veenendaal, A.K.J., Sundin, C. and Blocker, A.J. (2009) Small-molecule type III secretion system inhibitors block assembly of the Shigella type III secreton. J. Bacteriol. 191, 563-570.