Avison, Matthew - University of Bristol - School of Cellular and Molecular Medicine

研究领域

Novel Two-component signal transduction systems in bacteria - functional genomic analyses. Regulation of chromosomal β-lactamase production in Gram-negative bacteria - biochemical and molecular genetic analyses. Functional analysis and regulation of multidrug efflux pump expression in Gram-negative bacteria. Antibiotic induced mutation and bacteriophage induction in Campylobacter jejuni and E. coli. Predicting evolutionary potential of mobile antimicrobial drug resistance genes. Testing novel antimicrobial drugs and inhibitors of antibiotic resistance.

近期论文

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Brem, J., van Berkel, S.S., Aik, W., Rydzik, A.M., Avison, M.B., Pettinati, I., Umland, K.D., Kawamura, A., Spencer, J., Claridge, T.D., McDonough, M.A. and Schofield, C.J. (2014) Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition. Nature Chemistry 6, 1084-1090. Talfan, A., Mounsey, O., Charman, M., Townsend, E. and Avison, M.B. (2013) Involvement of mutation in ampD I, mrcA, and at least one additional gene in β-lactamase hyperproduction in Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 57, 5486-5491 Gould, V.C., Okazaki, A. and Avison, M.B. (2013) Coordinate hyper-production and SmeZ and SmeJK efflux pumps extends drug resistance in Stentrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 57, 655-657 Tayler, A.E., Ayala, J.A., Niumsup, P., Westphal, K., Baker, J.A., Zhang, L., Walsh, T.R., Wiedemann, B., Bennett, P.M., and Avison, M.B. (2010) Induction of β-lactamase production in Aeromonas hydrophila is responsive to β-lactam-mediated changes in peptidoglycan composition. Microbiology 156, 2327-2335. Cariss, S.J., Constantinidou, C., Patel, M.D., Takebayashi, Y., Hobman, J.L., Penn, C.W., and Avison, M.B. (2010) YieJ (CbrC) mediates CreBC-dependent colicin E2 tolerance in Escherichia coli. Journal of Bacteriology 192, 3329-3336. Ryan, R.P., Monchy, S., Cardinale, M., Taghavi, S., Crossman, L.C., Avison, M.B., Berg, G., van der Lelie, D., and Dow, J.M. (2009) The versatility and adaptation of bacteria from the genus Stenotrophomonas. Nature Reviews Microbiology 7, 414-425. Crossman, L.C., Gould, V.C., Dow, J.M., Vernikos, G.S., Okazaki, A., Sebaihia, M., Saunders, D., Arrowsmith, C., Carver, T., Peters, N., Adlem, E., Kerhornou, A., Lord, A., Murphy, L., Seeger, K., Squares, R., Rutter, S., Quail, M.A., Rajandream, M.A., Harris, D., Churcher, C., Bentley, S.D., Parkhill, J., Thomson, N.R. and Avison, M.B. (2008) The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants. Genome Biology 9, R74, 13pp. Cariss, S.J.L., Tayler, A.E. and Avison, M.B. (2008) Defining the growth conditions and promoter-proximal DNA sequences required for activation of gene expression by CreBC in Escherichia coli. Journal of Bacteriology. 190, 3930-3939.