Kamp, Marc Van der - University of Bristol

个人简介

Marc obtained a first-class (cum laude) MSc in Molecular Sciences at Wageningen University in the Netherlands. During two MSc research projects, he gained experience with both computational and experimental biochemical methods. He subsequently specialized in computational modelling during an internship at a pharmaceutical company. After a short period as a pre-doctoral research assisstant, he took up a Marie Curie Early Stage Research Fellowship with Adrian Mulholland at the University of Bristol, to work on applying a range of QM/MM techniques to enzyme reactions. After extending his postgraduate research with an IBM Research Fellowship, he obtained his PhD in 2008. Then, he moved to the University of Washington to work with Valerie Daggett on applying molecular dynamics simulation to study protein dynamics in general and specifically prion protein misfolding. After 2 1/2 years in the Daggett lab, he moved back to Bristol and worked as a senior postdoc in the Mulholland group from 2011-2015. During this period, he worked on a variety of projects (often in collaboration with experimentalists) related to enzyme dynamics, catalysis and design, again using QM/MM and molecular dynamics methods. For most of 2015, Marc was a senior Research Associate with the BrisSynBio research centre. He then took up his David Phillips Fellowship to start his own research group in the School of Biochemistry and the BrisSynBio research centre, and affiliated with the Centre for Computational Chemistry.

研究领域

Other research interests are: enzymes involved in antibiotic resistance, computational simulation methods to aid drug design and fundamental principles of enzyme catalysis

近期论文

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Kamp, MWvd & Mulholland, AJ, 2013, ‘Combined quantum mechanics/molecular mechanics (QM/MM) methods in computational enzymology’. Biochemistry, vol 52., pp. 2708-28 Chudyk, EI, Limb, MAL, Jones, C, Spencer, J, Kamp, MWVd & Mulholland, AJ, 2014, ‘QM/MM simulations as an assay for carbapenemase activity in class A β-lactamases’. Chemical Communications, vol 50., pp. 14736-14739 Daniels, AD, Campeotto, I, Kamp, MWvd, Bolt, AH, Trinh, CH, Phillips, SEV, Pearson, AR, Nelson, A, Mulholland, AJ & Berry, A, 2014, ‘Reaction Mechanism of N-Acetylneuraminic Acid Lyase Revealed by a Combination of Crystallography, QM/MM Simulation, and Mutagenesis’. ACS Chemical Biology, vol 9., pp. 1025-1032 Kamp, MWvd, Zurek, J, Manby, FR, Harvey, JN & Mulholland, AJ, 2010, ‘Testing high-level QM/MM methods for modeling enzyme reactions: acetyl-CoA deprotonation in citrate synthase’. Journal of Physical Chemistry B, vol 114., pp. 11303-14