Szczelkun, Mark - University of Bristol

个人简介

Professor of Biochemistry, University of Bristol (2010 - present) Reader, University of Bristol (2007-2010) Senior Research Fellow, University of Bristol (2003-2007) Research Fellow, University of Bristol (1998-2003) Research Associate, University of Bristol (1994-1998) Research Assistant University of Southampton (1990-1993) Ph.D. in Biochemistry with Professor Bernard A. Connolly, University of Southampton (1990-1993) B.Sc. in Biochemistry (upper second class), University of Liverpool (1987-1990)

研究领域

Molecular Mechanisms of Genome Processing and Maintenance

近期论文

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Tan, BG, Wellesley, FC, Savery, NJ & Szczelkun, MD, 2016, ‘Length heterogeneity at conserved sequence block 2 in human mitochondrial DNA acts as a rheostat for RNA polymerase POLRMT activity’. Nucleic Acids Research, vol 44., pp. 7817-7829 Kulkarni, M, Nirwan, N, van Aelst, K, Szczelkun, M & Saikrishnan, K, 2016, ‘Structural insights into DNA sequence recognition by Type ISP restriction-modification enzymes’. Nucleic Acids Research, vol 44., pp. 4396-4408 Chand, M, Nirwan, N, Diffin, FM, van Aelst, K, Kulkarni, M, Pernstich, C, Szczelkun, MD & Saikrishnan, K, 2015, ‘Translocation-coupled DNA cleavage by the Type ISP restriction-modification enzymes’. Nature Chemical Biology, vol 11., pp. 870-877 van Aelst, K, Saikrishnan, K & Szczelkun, MD, 2015, ‘Mapping DNA cleavage by the Type ISP restriction-modification enzymes following long-range communication between DNA sites in different orientations’. Nucleic Acids Research, vol 43., pp. 10430-10443 Tóth, J, Bollins, JM & Szczelkun, MD, 2015, ‘Re-evaluating the kinetics of ATP hydrolysis during initiation of DNA sliding by Type III restriction enzymes’. Nucleic Acids Research, vol 43., pp. 10870-81 Szczelkun, MD, Tikhomirova, MS, Sinkunas, T, Gasiunas, G, Karvelis, T, Pschera, P, Siksnys, V & Seidel, R, 2014, ‘Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes’. Proceedings of the National Academy of Sciences (PNAS), vol 111., pp. 9798-9803 Butterer, A, Pernstich, C, Smith, RM, Sobott, F, Szczelkun, MD & Tóth, J, 2014, ‘Type III restriction endonucleases are heterotrimeric: comprising one helicase-nuclease subunit and a dimeric methyltransferase that binds only one specific DNA’. Nucleic Acids Research, vol 42., pp. 5139-50 Zaremba, M, Toliusis, P, Grigaitis, R, Manakova, E, Silanskas, A, Tamulaitiene, G, Szczelkun, MD & Siksnys, V, 2014, ‘DNA cleavage by CgII and NgoAVII requires interaction between N- and R-proteins and extensive nucleotide hydrolysis’. Nucleic Acids Research, vol 42., pp. 13887-13896 Simons, M, Diffin, FM & Szczelkun, MD, 2014, ‘ClpXP protease targets long-lived DNA translocation states of a helicase-like motor to cause restriction alleviation’. Nucleic Acids Research, vol 42., pp. 12082-12091 Schwarz, FW, Tóth, J, van Aelst, K, Cui, G, Clausing, S, Szczelkun, MD & Seidel, R, 2013, ‘The helicase-like domains of type III restriction enzymes trigger long-range diffusion along DNA’. Science, vol 340., pp. 353-6