Gaston, Kevin - University of Bristol - School of Biochemistry

个人简介

I graduated from Leicester University in 1986 with a B.Sc. in Biological Sciences. I then completed a Ph.D. in gene regulation at the University of Birmingham in 1989. After post-doctoral work at the Pasteur Institute in Paris and the CRUK London Institute I was appointed as a lecturer in Bristol in 1994. I am currently a Reader in Biochemistry

研究领域

Gene regulation

近期论文

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Noy, P, Williams, H, Sawasdichai, A, Gaston, K & Jayaraman, P-S, 2010, ‘PRH/Hex controls cell survival through coordinate transcriptional regulation of vascular endothelial growth factor signaling’. Molecular and Cellular Biology, vol 30 (9)., pp. 2120 - 2134 Soufi, A, Sawasdichai, A, Shukla, A, Noy, P, Dafforn, TR, Smith, CJI, Jayaraman, P-S & Gaston, K, 2010, ‘DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers’. Nucleic Acids Research, vol 38., pp. 7513-7525 Soufi, A, Noy, P, Buckle, M, Sawasdichai, A, Gaston, K & Jayaraman, P-S, 2009, ‘CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding’. Nucleic Acids Research, vol 37 ., pp. 3288 - 3300 Kershaw, R, Gaston, K & Jayaraman, P, 2013, ‘Proline Rich Homeodomain (PRH/HHEX) protein in the control of haematopoiesis and myeloid cell proliferation and its potential as a therapeutic target in myeloid leukaemias and other cancers.’. in: SA Douglas (eds) Myeloid Cells: Biology & Regulation, Role in Cancer Progression and Potential Implications for Therapy. NOVA Publishers Brown, CA, Leon, KC, Strickland, M, Williams, C, Fairweather, VSS, Brady, RL, Crump, MP & Gaston, K, 2011, ‘Protein flexibility directs DNA recognition by the papillomavirus E2 proteins’. Nucleic Acids Research, vol 39 ., pp. 2969-2980