Frayne, Jan - University of Bristol - School of Biochemistry

个人简介

Jan Frayne obtained her first degree from Nottingham University and PhD from Bristol University before commencing research in developmental biology, specifically sperm function. She moved to the Department of Biochemistry at the University of Bristol on a post-doctoral position within this area to develop skills in molecular biology, obtaining a lectureship here in 2000.

研究领域

The molecular analysis of erythroid cells generated in vitro from different stem cell sources

近期论文

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Wilson, M, Trakarnsanga, K, Heesom, K, Toye, A & Frayne, J, 2016, ‘Comparison of the proteome of adult and cord erythroid cells, and changes in the proteome following reticulocyte maturation’. Molecular and Cellular Proteomics, vol 15., pp. 1938-1946 Trakarnsanga, K, Wilson, MC, Griffiths, RE, Toye, AM, Carpenter, L, Heesom, KJ, Parsons, SF, Anstee, DJ & Frayne, J, 2014, ‘Qualitative and Quantitative Comparison of the Proteome of Erythroid Cells Differentiated from Human iPSCs and Adult Erythroid Cells by Multiplex TMT Labelling and NanoLC-MS/MS’. PLOS ONE, vol 9., pp. e100874 Trakarnsanga, K, Wilson, MC, Lau, WWY, Singleton, BK, Parsons, SF, Sakuntanaga, P, Kurita, R, Nakamura, Y, Anstee, DJ & Frayne, J, 2014, ‘Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL’. Haematologica. Taylor, A, Robson, A, Houghton, BC, Jepson, CA, Ford, WCL & Frayne, J, 2013, ‘Epididymal specific, selenium-independent GPX5 protects cells from oxidative stress-induced lipid peroxidation and DNA mutation’. Human reproduction (Oxford, England), vol 28., pp. 2332-2342 Singleton, BK, Frayne, J & Anstee, DJ, 2012, ‘Blood group phenotypes resulting from mutations in erythroid transcription factors.’. Current Opinion in Hematology, vol 19., pp. 486-493 Singleton, B, Lau, W, Fairweather, V, Burton, N, Wilson, M, Parsons, S, Richardson, B, Trakarnsanga, K, Brady, R, Anstee, D & Frayne, J, 2011, ‘Mutations in the second zinc finger of human EKLF reduce promoter affinity but give rise to benign and disease phenotypes’. Blood, vol 118., pp. 3137 - 3145 Chaikuad, A, Shafqat, N, Al-Mokhtar, R, Cameron, G, Clarke, A, Brady, R, Oppermann, U, Frayne, J & Yue, W, 2011, ‘Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS’. Biochemical Journal, vol 435 (2)., pp. 401 - 409 Frayne, J, Taylor, A, Cameron, G & Hadfield, A, 2009, ‘Structure of insoluble rat sperm glyceraldehyde-3-phosphate dehydrogenase (GAPDH) via heterotetramer formation with Escherichia coli GAPDH reveals target for contraceptive design’. Journal of Biological Chemistry, vol 284 (34)., pp. 22703 - 22712 Richardson, B, Heesom, K, Parsons, S, Anstee, D & Frayne, J, 2009, ‘Analysis of the differential proteome of human erythroblasts during in vitro erythropoiesis by 2-D DIGE’. Proteomics - Clinical applications, vol 3 (9)., pp. 1123 - 1134 Singleton, BK, Fairweather, VSS, Lau, W, Parsons, SF, Burton, NM, Frayne, J, Brady, RL & Anstee, DJ, 2009, ‘A Novel EKLF Mutation in a Patient with Dyserythropoietic Anemia: The First Association of EKLF with Disease in Man.’. Blood, vol 114., pp. 72-72