Dempsey, Christopher - University of Bristol

个人简介

Chris Dempsey researches into the molecular basis of membrane ion channel function. He graduated with a degree in Chemistry from St Andrews University in Scotland and did his PhD with Charles Vernon in the Chemistry Department at University College, London. Interests in NMR spectroscopy and spectroscopic analysis of membrane proteins developed during postdoctoral work at Oxford University. Following a period in Don Engelman's lab at Yale University studying molecular biology and membrane protein expression he returned to the UK and Bristol University.

研究领域

Structure and Function of Membrane Ion Channel Proteins

近期论文

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Armstrong, CT, Mason, P, Anderson, JLR & Dempsey, CE, 2016, ‘Arginine side chain interactions and the role of arginine as a gating charge carrier in voltage sensitive ion channels’. Scientific Reports, vol 6. Colenso, CK, Cao, Y, Sessions, RB, Hancox, JC & Dempsey, CE, 2014, ‘Voltage sensor gating charge transfer in a HERG potassium channel model’. Biophysical journal, vol 107., pp. L25-8 Du, C, Zhang, YH, El Harchi, A, Dempsey, CE & Hancox, JC, 2014, ‘Ranolazine inhibition of hERG potassium channels: drug-pore interactions and reduced potency against inactivation mutants’. Journal of Molecular and Cellular Cardiology, vol 74., pp. 220-230 Dempsey, CE, Wright, D, Colenso, CK, Sessions, RB & Hancox, JC, 2014, ‘Assessing hERG pore models as templates for drug docking using published experimental constraints: The inactivated state in the context of drug block.’. Journal of Chemical Information and Modeling, vol 54., pp. 601-612 Colenso, CK, Sessions, RB, Zhang, YH, Hancox, J & Dempsey, CE, 2013, ‘Interactions between voltage sensor and pore domains in a hERG K(+) channel model from molecular simulations, and the effects of a voltage sensor mutation’. Journal of Chemical Information and Modeling, vol 53., pp. 1358-1370 El Harchi, A, Zhang, Y, Hussein, L, Dempsey, C & Hancox, J, 2012, ‘Molecular determinants of hERG potassium channel inhibition by disopyramide’. Journal of Molecular and Cellular Cardiology, vol 52., pp. 185 - 195 Dempsey, C, Mason, P & Jungwirth, P, 2011, ‘Complex ion effects on polypeptide conformational stability: Chloride and sulfate salts of guanidinium and tetrapropylammonium’. Journal of American Chemical Society, vol 133 (19)., pp. 7300 - 7303 Dempsey, C, Hawrani, A, Howe, R & Walsh, T, 2010, ‘Amphipathic antimicrobial peptides- from biophysics to therapeutics?’. Protein & Peptide Letters, vol 17 (11)., pp. 1334 - 1344 Mason, P, Dempsey, C, Neilson, G, Kline, S & Brady, J, 2009, ‘Preferential interactions of guanidinium ions with aromatic groups over aliphatic groups’. Journal of the American Chemical Society, vol 131 ., pp. 16689 - 16696 Hawrani, A, Howe, R, Walsh, T & Dempsey, C, 2008, ‘Origin of low mammalian cell toxicity in a class of highly active antimicrobialamphipathic helical peptides’. Journal of Biological Chemistry, vol 283 ., pp. 18636 - 18645