Brady, Leo - University of Bristol - School of Biochemistry

个人简介

Professor of Biochemistry, University of Bristol (2001 - present) Head of the School of Biochemistry, University of Bristol (2009-2014) Reader in Biochemistry, University of Bristol (1996-2001) Lecturer in Biochemistry, University of Bristol (1994-1996) MRC AIDS Senior Fellow, University of York/University of Bristol (1990-1995) Postdoctoral Fellow, University of York (1988-1990) Research Assistant, Dept of Chemistry, University of York (1985-1987) Research Assistant, Yale University, CT, USA (1984-1985) Research Assistant, University of Sydney (1983-1984)

研究领域

Structural biology of pathogenesis

近期论文

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Burton, AJ, Thomson, D, Dawson, WM, Brady, RL & Woolfson, DN, 2016, ‘Installing hydrolytic activity into a completely de novo protein framework’. Nature Chemistry, vol 8., pp. 837-844 Burgess, NC, Sharp, TH, Thomas, F, Wood, CW, Thomson, AR, Zaccai, NR, Brady, RL, Serpell, LC & Woolfson, DN, 2015, ‘Modular Design of Self-Assembling Peptide-Based Nanotubes’. Journal of the American Chemical Society, vol 137., pp. 10554-10562 Wood, CW, Bruning, M, Ibarra, AA, Bartlett, GJ, Thomson, AR, Sessions, RB, Brady, RL & Woolfson, DN, 2014, ‘CCBuilder: An interactive web-based tool for building, designing and assessing coiled-coil protein assemblies’. Bioinformatics, vol 30., pp. 3029-3035 Thomson, AR, Wood, CW, Burton, AJ, Bartlett, GJ, Sessions, RB, Brady, RL & Woolfson, DN, 2014, ‘Computational design of water-soluble α-helical barrels’. Science, vol 346., pp. 485-488 Burton, AJ, Thomas, F, Agnew, C, Hudson, KL, Halford, SE, Brady, RL & Woolfson, DN, 2013, ‘Accessibility, Reactivity, and Selectivity of Side Chains within a Channel of de Novo Peptide Assembly’. Journal of the American Chemical Society, vol 135., pp. 12524-12527 Sharp, TH, Bruning, M, Mantell, JM, Sessions, RB, Thomson, AR, Zaccai, NR, Brady, RL, Verkade, P & Woolfson, DN, 2012, ‘Cryo-transmission electron microscopy structure of a gigadalton peptide fiber of de novo design’. Proceedings of the National Academy of Sciences of the United States of America, vol 109., pp. 13266-13271 Fletcher, JM, Boyle, AL, Bruning, M, Bartlett, GJ, Vincent, TL, Zaccai, NR, Armstrong, CT, Bromley, EHC, Booth, PJ, Brady, RL, Thomson, AR & Woolfson, DN, 2012, ‘A basis set of de novo coiled-coil peptide oligomers for rational protein design and synthetic biology’. Acs synthetic biology, vol 1., pp. 240-250 Brady, R, R.J., AC & G.S., WA, 2012, ‘An enlarged, adaptable active site in CYP164 family P450 enzymes from M. smegmatis and M. leprae’. Antimicrob. Agents Chemother, vol 56., pp. 391-402 Ambre, PK, Pissurlenkar, RRS, Jagyasi, AS, Fule, A, Khedkar, V, Barhate, CR, Vivas, L, Tripathi, AK, Sullivan, D, Birkinshaw, R, Brady, RL, Iyer, K & Coutinho, EC, 2012, ‘Molecular modeling studies, synthesis and biological evaluation of novel Plasmodium falciparum lactate dehydrogenase (pfLDH) inhibitors’. Anti-Infective Agents, vol 10., pp. 55-71 Agnew, CRJ, Warrilow, AGS, Burton, NM, Lamb, DC, Kelly, SL & Brady, RL, 2012, ‘An Enlarged, Adaptable Active Site in CYP164 Family P450 Enzymes, the Sole P450 in Mycobacterium leprae’. Proc. Antimicrobial Agents and Chemotherapy, vol 56., pp. 391-402