Berger, Imre - University of Bristol - School of Biochemistry

个人简介

Imre Berger was trained as a biochemist and molecular biologist at Leibniz University and Medical School (MHH) in Hannover (Germany), at MIT (Cambridge, USA), and at ETH Zurich (Switzerland). His team develops enabling methods for researching large multiprotein complexes and investigates their structure and mechanisms in human health and disease. In 2007, Berger became Group Leader and Principal Investigator for eukaryotic complexes at the EMBL Grenoble and at the EMBL Genome Biology Unit in Heidelberg, with a joint appointment at the International Research Unit of Virus Host-Cell Interactions (UVHCI) in Grenoble. In 2014, he was appointed Full Professor at the School of Biochemistry, University of Bristol, UK. Imre Berger has developed the MultiBac, ACEMBL and ComplexLink systems for multiprotein research, which are in use in some of the best laboratories world-wide. He holds international patents for protein technologies, co-founded two companies, and received numerous distinctions, including the Swiss Technology Award, the W.A. DeVigier Foundation Award and a Wellcome Trust Senior Investigator Award for his innovative research. Prof. Berger has participated in leading roles in numerous European Commission (EC) projects, including INSTRUCT, the pan-European infrastructure for structural biology. Berger has been Coordinator of the EC FP7 HEALTH ComplexINC project for enhancing production tools for next-generation complex biologics in academic and industrial R&D (2011-2016).

近期论文

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Gupta, K, Sari-Ak, D, Haffke, M, Trowitzsch, S & Berger, I, 2016, ‘Zooming in on Transcription Preinitiation’. Journal of Molecular Biology, vol 428., pp. 2581-2591 Gupta, K & Berger, I, 2016, ‘The MultiBac Baculovirus/Insect Cell Expression Vector System for Producing Complex Protein Biologics’. in: M Cristina Vega (eds) Advanced Technologies for Protein Complex Production and Characterization. Springer, pp. 199-215 Monteiro, F, Bernal, V, Chaillet, M, Berger, I & Alves, PM, 2016, ‘Targeted supplementation design for improved production and quality of enveloped viral particles in insect cell-baculovirus expression system’. Journal of Biotechnology, vol 233., pp. 34-41 Komar, J, Alvira-de-Celis, S, Schulze, R, Martin, R, Nijeholtb, JALA, Lee, S, Dafforn, T, Deckers-Hebestreit, G, Berger, I, Berger-Schaffitzel, C & Collinson, I, 2016, ‘Membrane protein insertion and assembly by the bacterial holo-translocon SecYEG-SecDF-YajC-YidC’. Biochemical Journal. Zhang, W, Aubert, A, Segura, JGd, Karuppasamy, M, Basu, S, Murthy, A, Diamante, A, Drury, T, Balmer, J, Cramard, J, Watson, A, Lando, D, Lee, S, Palayret, M, Kloet, S, Smits, A, Deery, M, Vermeulen, M, Hendrich, B, Klenerman, D, Berger-Schaffitzel, CH, Berger, I & Laue, E, 2016, ‘The Nucleosome Remodeling and Deacetylase Complex NuRD is built from preformed catalytically active sub-modules’. Journal of Molecular Biology. Mansouri, MM, Bellon-Echeverria, I, Rizk, A, Ehsaei, Z, Cosentino, CC, Silva, CS & Berger, I, 2016, ‘Highly efficient baculovirus-mediated multigene delivery in primary cells’. Nature Communications, vol 7. Swale, C, Monod, A, Tengo, L, Labaronne, A, Garzoni, F, Bourhis, J-M, Cusack, S, Schoehn, G, Berger, I, Ruigrok, RWH & Crépin, T, 2016, ‘Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5’. Scientific Reports, vol 6. Nie, Y, Chaillet, M, Becke, C, Haffke, M, Pelosse, M, Fitzgerald, D, Collinson, I, Berger-Schaffitzel, C & Berger, I, 2016, ‘ACEMBL Tool-Kits for High-Throughput Multigene Delivery and Expression in Prokaryotic and Eukaryotic Hosts’. in: M Cristina Vega (eds) Advanced Technologies for Protein Complex Production and Characterization. Springer International Publishing, pp. 27-42 Abdulrahman, W, Radu, L, Garzoni, F, Kolesnikova, O, Gupta, K, Osz-Papai, J, Berger, I & Poterszman, A, 2015, ‘The production of multiprotein complexes in insect cells using the baculovirus expression system’. Methods in molecular biology (Clifton, N.J.), vol 1261., pp. 91-114 Komar, J, Botte, M, Collinson, IR, Berger-Schaffitzel, CH & Berger, I, 2015, ‘ACEMBLing a Multiprotein Transmembrane Complex: The Functional SecYEG-SecDF-YajC-YidC Holotranslocon Protein Secretase/Insertase.’. Methods in Enzymology, vol 556., pp. 23-49