卢帅 - 中国药科大学

个人简介

2012年毕业于中国药科大学药物化学专业，获得理学博士学位，2013年进入中国药科大学理学院有机化学教研室工作至今，现为副教授。2016年3月至2017年3月在美国University of Minnesota著名药物化学家Gunda I. Georg课题组做国家公派访问学者。

研究领域

研究方向为小分子靶向抗肿瘤药物的设计与合成，以及利用CADD和AI技术发现针对肿瘤、炎症等疾病的新分子实体。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Wang ZJ, Cai JH, Ren JW, Chen Y, Wu YL, Cheng J, Jia K, Huang F, Cheng ZT, Sheng TC, Song SY, Heng H, Zhu YF, Tang WF, Li HM*, Lu T*, Chen YD*, Lu S*. Discovery of a Potent FLT3 Inhibitor (LT-850-166) with Capacity of Overcoming a Variety of FLT3 Mutations. [J]. J. Med. Chem. 2021, 64 (19), 14664-14701. Wang ZJ, Cai JH, Cheng J, Yang WQZ, Zhu YF, Li HM, Lu T*, Chen YD*, Lu S*. FLT3 inhibitors in acute myeloid leukemia: challenges and recent developments in overcoming resistance [J]. J. Med. Chem. 2021, 64 (6), 2878-2900. Cui QJ#, Lu S#, Ni BW, Zeng X, Tan Y, Chen YD*, Zhao HP*. Improved prediction of aqueous solubility of novel compounds by going deeper with deep learning [J]. Front. Oncol. 2020, 10, 121. Bao JY #, Liu HC #, Zhi YL, Yang WQZ, Zhang JW, Lu T, Wang Y *, Lu S *. Discovery of benzo[d]oxazole derivatives as the potent type-I FLT3-ITD inhibitors [J]. Bioorg. Chem. 2020, 94, 103248. Heng H#, Wang ZJ#, Li HM#, Huang YT, Lan QY, Guo XX, Zhang L, Zhi YL, Cai JH, Qin TR, Xiang L, Wang SX, Chen YD*, Lu T, Lu S*. Combining structure- and property-based optimization to identify selective FLT3-ITD inhibitors with good antitumor efficacy in AML cell inoculated mouse xenograft model [J]. Eur. J. Med. Chem. 2019, 176, 248-267. Ran T#, Li WJ#, Peng BL, Xie BL, Lu T, Lu S*, Liu W*. Virtual Screening with a Structure-Based Pharmacophore Model to Identify Small-Molecule Inhibitors of CARM1 [J]. J. Chem. Inf. Model. 2019, 59(1), 522-534. Heng H#, Zhi YL#, Yuan HL#, Wang ZJ, Li HM, Wang SX, Tian JY, Liu HC, Chen YD, Lu T*, Ran T*, Lu S*. Discovery of a highly selective FLT3 inhibitor with specific proliferation inhibition against AML cells harboring FLT3-ITD mutation [J]. Eur. J. Med. Chem. 2019, 163, 195-206. Zhi YL, Li BQ, Yao C, Li HM, Chen PZ, Bao JY, Qin TR, Wang Y, Lu T*, Lu S*. Discovery of the selective and efficacious inhibitors of FLT3 mutations [J]. Eur. J. Med. Chem. 2018, 155, 303-315.