Shan, Libo - Texas A&M University - Department of Biochemistry and Biophysics

个人简介

Beijing Normal University, China B.S. 1995 Chinese Academy of sciences, China M.S. 1998 Kansas State University Ph.D. 2003 Harvard Medical School, Boston Res. Fellow 2003-2008 Joined Texas A&M in 2009

研究领域

Earth is the planet of the plants. Being autotrophic, sessile, and long-living entities, plants have evolved fascinating strategies to cope with various environmental stresses. Our research is driven by the desire to understand the fundamental principles underlying plant disease resistance, and pathogen virulence, and to improve crop resilience to pathogen infections. We are probing the biochemical and genetic basis of plant signal transduction pathways from cell surface receptors sensing the presence of pathogens to signaling cascades and target genes and proteins that are central to launch effective immune responses in the context of balanced growth and development. We deploy cutting-edge molecular and biochemical technologies coupled with powerful genetic tractability of plants for discovering regulatory networks of living organisms fending off infections. In addition to the acquisition of foundational principles in biology, we further translate knowledge and platforms into the areas for the improvement of crop stress adaptation.

近期论文

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Wang P, Zhou L, Jamieson P, Zhang L, Zhao Z, Babilonia K, Shao W, Wu L, Mustafa R, Amin I, Diomaiuti A, Pontiggia D, Ferrari S, Hou Y, He P, Shan L. The Cotton Wall-associated Kinase GhWAK7A Mediates Responses to Fungal Wilt Pathogens by Complexing with the Chitin Sensory Receptors. The Plant Cell. 2020 Dec 1;32(12):3978-4001. http://www.plantcell.org/content/32/12/3978.abstract Huang Y, Yin C, Liu J, Feng B, Ge D, Kong L, Ortiz-Morea FA, Richter J, Hauser MT, Wang WM, Shan L, He P. A trimeric CrRLK1L-LLG1 complex genetically modulates SUMM2-mediated autoimmunity. Nature Communications. 2020 Sep 25;11(1):4859. https://www.nature.com/articles/s41467-020-18600-8 Liu J, Huang Y, Kong L, Yu X, Feng B, Liu D, Zhao B, Mendes GC, Yuan P, Ge D, Wang WM, Fontes EPB, Li P, Shan L, He P. The malectin-like receptor-like kinase LETUM1 modulates NLR protein SUMM2 activation via MEKK2 scaffolding. Nature Plants. 2020 Sep;6(9):1106-1115. https://www.nature.com/articles/s41477-020-0748-6 Ma X, Claus LAN, Leslie ME, Tao K, Wu Z, Liu J, Yu X, Li B, Zhou J, Savatin DV, Peng J, Tyler BM, Heese A, Russinova E, He P, Shan L. Ligand-induced monoubiquitination of BIK1 regulates plant immunity. Nature. 2020 May;581(7807):199-203. https://www.nature.com/articles/s41586-020-2210-3 Liu J, Li J, Shan L. SERKs. Current Biology. 2020 Apr 6;30(7):R293-4. https://www.sciencedirect.com/science/article/pii/S0960982220300877?via%3Dihub Yang Y, Liu J, Yin C, de Souza Vespoli L, Ge D, Huang Y, Feng B, Xu G, Manhães AMEA, Dou S, Criswell C, Shan L, Wang X, He P. RNA Interference-Based Screen Reveals Concerted Functions of MEKK2 and CRCK3 in Plant Cell Death Regulation. Plant Physiology. 2020 May;183(1):331-344. https://doi.org/10.1104/pp.19.01555 Levy JG, Gross R, Mendoza-Herrera A, Tang X, Babilonia K, Shan L, Kuhl JC, Dibble MS, Xiao F, Tamborindeguy C. Lso-HPE1, an Effector of ‘Candidatus Liberibacter solanacearum’, Can Repress Plant Immune Response. Phytopathology. 2020 Mar;110(3):648-655. https://doi.org/10.1094/PHYTO-07-19-0252-R. Cox, K. L., Babilonia, K., He, P., and Shan, L. (2019) Return of old foes – recurrence of bacterial blight and fusarium wilt of cotton. Current Opinion in Plant Biology 50: 95-103. https://www.sciencedirect.com/science/article/pii/S1369526618301195 Xiong, C., Luo, D., Lin, A., Zhang, C., Shan, L., He, P., Li, B., Zhang, Q., Hua, B., Yuan, Z., Li, H., Zhang, J., Yang, C., Lu, Y., Ye, Z., and Wang, T. (2019) A tomato B-box protein SlBBX20 modulates carotenoid biosynthesis by directly activating PHYTOENE SYNTHASE 1, and is targeted for 26S proteasome-mediated degradation. New Phytologist 221: 279–294. https://nph.onlinelibrary.wiley.com/doi/full/10.1111/nph.15373 Chen, C., Yang, S., Liu, Y., Jamieson, P., Shan, L., and Chu, K. (2019) Accumulation and phytotoxicity of perfluorooctanoic acid and 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate in Arabidopsis thaliana and Nicotiana benthamiana. Environmental Pollution 259:113817 https://www.sciencedirect.com/science/article/pii/S0269749119354405?via%3Dihub Li B, Ferreira MA, Huang M, Camargos LF, Yu X, Teixeira RM, Carpinetti PA, Mendes GC, Gouveia-Mageste BC, Liu C, Pontes CSL, Brustolini OJB, Martins LGC, Melo BP, Duarte CEM, Shan L, He P, Fontes EPB. The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity. Nature Communications. 2019 Nov 1;10(1):4996. https://pubmed.ncbi.nlm.nih.gov/31676803/ Yu X, Xu G, Li B, de Souza Vespoli L, Liu H, Moeder W, Chen S, de Oliveira MVV, Ariádina de Souza S, Shao W, Rodrigues B, Ma Y, Chhajed S, Xue S, Berkowitz GA, Yoshioka K, He P, Shan L. The Receptor Kinases BAK1/SERK4 Regulate Ca2+ Channel-Mediated Cellular Homeostasis for Cell Death Containment. Current Biology. 2019 Nov 18;29(22):3778-3790.e8. https://pubmed.ncbi.nlm.nih.gov/31679931/ Yu X, Li B, Jang GJ, Jiang S, Jiang D, Jang JC, Wu SH, Shan L, He P. Orchestration of processing body dynamics and mRNA decay in Arabidopsis immunity. Cell reports. 2019 Aug 20;28(8):2194-205. https://www.sciencedirect.com/science/article/pii/S2211124719309581 Mu C, Zhou L, Shan L, Li F, Li Z. Phosphatase GhDs PTP 3a interacts with annexin protein Gh ANN 8b to reversely regulate salt tolerance in cotton (Gossypium spp.). New Phytologist. 2019 Sep;223(4):1856-72. https://nph.onlinelibrary.wiley.com/doi/abs/10.1111/nph.15850 Zhou J, Wang P, Claus LA, Savatin DV, Xu G, Wu S, Meng X, Russinova E, He P, Shan L. Proteolytic processing of SERK3/BAK1 regulates plant immunity, development, and cell death. Plant physiology. 2019 May 1;180(1):543-58. http://www.plantphysiol.org/content/180/1/543.abstract Levy, Julien Gad, Rachel Gross, M. Azucena Mendoza Herrera, Xiaotian Tang, Kevin Babilonia, Libo Shan, Joseph Kuhl, Maggie Dibble, Fangming Xiao, and Cecilia Tamborindeguy. “Lso-HPE1, an effector of ‘Candidatus Liberibacter solanacearum’can repress plant immune response.” Phytopathology ja (2019). https://apsjournals.apsnet.org/doi/full/10.1094/PHYTO-07-19-0252-R Wan, W., Zhang, L., Pruitt, R., Zaidem, M., Brugman, R., Ma, X., Krol, E., Perraki, A., Kilian, J., Grossmann, G., Stahl, M., Shan, L., Zipfel, C., van Kan, J., Hedrich, R., Weigel, D., Gust, A., and Nuernberger, T. Comparing Arabidopsis receptor kinase and receptor protein-mediated immune signaling reveals BIK1-dependent differences. New Phytologist (2018). https://nph.onlinelibrary.wiley.com/doi/full/10.1111/nph.15497 Shan, L., and He, P. (2018) Pipped at the post: pipecolic acid derivative identified as SAR regulator. Cell 173:286-287. https://doi.org/10.1016/j.cell.2018.03.045 Jamieson, P.A., Shan, L., and He, P. Plant cell surface molecular cypher: receptor-like proteins and their roles in immunity and development. Plant Science 274:242-251. https://pubmed.ncbi.nlm.nih.gov/30080610/ Lal, N.K., Nagalakshmi, U., Hurlburt, N.K., Flores, R., Bak, A., Sone, P., Ma, X., Song, G., Walley, J., Shan, L., He, P., Casteel, C., Andrew J. Fisher, A.J., and Dinesh-Kumar, S.P. (2018) Nuclear role of a plant receptor-like cytoplasmic kinase in hormone regulation during innate immunity. Cell Host & Microbe 23:485-497. https://pubmed.ncbi.nlm.nih.gov/29649442/