He, Ping - Texas A&M University - Department of Biochemistry and Biophysics

个人简介

China Agricultural University, China B.S. 1993 Chinese Academy of sciences, China M.S. 1998 Kansas State University Ph.D. 2003 Harvard Medical School, Boston Postdoc.2003-2008 Joined Texas A&M in 2009

研究领域

Plants have developed the sophisticated innate immune system to defend pathogen attacks. Our primary research interest is to elucidate the activation and signaling mechanisms of host immunity upon pathogen infections with an integrated genetic, biochemical, and cellular approach using Arabidopsis as a tractable model system. Plant immunity is inextricably linked with plant development and environmental stresses. We are trying to understand the signaling crosstalk that orchestrates plant responses to different extrinsic and intrinsic signals. Ultimately, knowledge gained from studying model plants will be applied to improve crop plants for stress resilience.

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Wang P, Zhou L, Jamieson P, Zhang L, Zhao Z, Babilonia K, Shao W, Wu L, Mustafa R, Amin I, Diomaiuti A, Pontiggia D, Ferrari S, Hou Y, He P, Shan L. The Cotton Wall-associated Kinase GhWAK7A Mediates Responses to Fungal Wilt Pathogens by Complexing with the Chitin Sensory Receptors. The Plant Cell. 2020 Dec 1;32(12):3978-4001. http://www.plantcell.org/content/32/12/3978.abstract Huang Y, Yin C, Liu J, Feng B, Ge D, Kong L, Ortiz-Morea FA, Richter J, Hauser MT, Wang WM, Shan L, He P. A trimeric CrRLK1L-LLG1 complex genetically modulates SUMM2-mediated autoimmunity. Nature Communications. 2020 Sep 25;11(1):4859. https://www.nature.com/articles/s41467-020-18600-8 Liu J, Huang Y, Kong L, Yu X, Feng B, Liu D, Zhao B, Mendes GC, Yuan P, Ge D, Wang WM, Fontes EPB, Li P, Shan L, He P. The malectin-like receptor-like kinase LETUM1 modulates NLR protein SUMM2 activation via MEKK2 scaffolding. Nature Plants. 2020 Sep;6(9):1106-1115. https://www.nature.com/articles/s41477-020-0748-6 Ma X, Claus LAN, Leslie ME, Tao K, Wu Z, Liu J, Yu X, Li B, Zhou J, Savatin DV, Peng J, Tyler BM, Heese A, Russinova E, He P, Shan L. Ligand-induced monoubiquitination of BIK1 regulates plant immunity. Nature. 2020 May;581(7807):199-203. https://www.nature.com/articles/s41586-020-2210-3 Yang Y, Liu J, Yin C, de Souza Vespoli L, Ge D, Huang Y, Feng B, Xu G, Manhães AMEA, Dou S, Criswell C, Shan L, Wang X, He P. RNA Interference-Based Screen Reveals Concerted Functions of MEKK2 and CRCK3 in Plant Cell Death Regulation. Plant Physiology. 2020 May;183(1):331-344. https://doi.org/10.1104/pp.19.01555 Cox, K. L., Babilonia, K., He, P., and Shan, L. (2019) Return of old foes – recurrence of bacterial blight and fusarium wilt of cotton. Current Opinion in Plant Biology 50: 95-103. https://www.sciencedirect.com/science/article/pii/S1369526618301195 Xiong, C., Luo, D., Lin, A., Zhang, C., Shan, L., He, P., Li, B., Zhang, Q., Hua, B., Yuan, Z., Li, H., Zhang, J., Yang, C., Lu, Y., Ye, Z., and Wang, T. (2019) A tomato B-box protein SlBBX20 modulates carotenoid biosynthesis by directly activating PHYTOENE SYNTHASE 1, and is targeted for 26S proteasome-mediated degradation. New Phytologist 221: 279–294. https://nph.onlinelibrary.wiley.com/doi/full/10.1111/nph.15373 Li B, Ferreira MA, Huang M, Camargos LF, Yu X, Teixeira RM, Carpinetti PA, Mendes GC, Gouveia-Mageste BC, Liu C, Pontes CSL, Brustolini OJB, Martins LGC, Melo BP, Duarte CEM, Shan L, He P, Fontes EPB. The receptor-like kinase NIK1 targets FLS2/BAK1 immune complex and inversely modulates antiviral and antibacterial immunity. Nature Communications. 2019 Nov 1;10(1):4996. https://pubmed.ncbi.nlm.nih.gov/31676803/ Yu X, Xu G, Li B, de Souza Vespoli L, Liu H, Moeder W, Chen S, de Oliveira MVV, Ariádina de Souza S, Shao W, Rodrigues B, Ma Y, Chhajed S, Xue S, Berkowitz GA, Yoshioka K, He P, Shan L. The Receptor Kinases BAK1/SERK4 Regulate Ca2+ Channel-Mediated Cellular Homeostasis for Cell Death Containment. Current Biology. 2019 Nov 18;29(22):3778-3790.e8. https://pubmed.ncbi.nlm.nih.gov/31679931/ Yu X, Li B, Jang GJ, Jiang S, Jiang D, Jang JC, Wu SH, Shan L, He P. Orchestration of processing body dynamics and mRNA decay in Arabidopsis immunity. Cell reports. 2019 Aug 20;28(8):2194-205. https://www.sciencedirect.com/science/article/pii/S2211124719309581 Zhou J, Wang P, Claus LA, Savatin DV, Xu G, Wu S, Meng X, Russinova E, He P, Shan L. Proteolytic processing of SERK3/BAK1 regulates plant immunity, development, and cell death. Plant physiology. 2019 May 1;180(1):543-58. http://www.plantphysiol.org/content/180/1/543.abstract Shan, L., and He, P. (2018) Pipped at the post: pipecolic acid derivative identified as SAR regulator. Cell 173:286-287. https://doi.org/10.1016/j.cell.2018.03.045 Jamieson, P.A., Shan, L., and He, P. Plant cell surface molecular cypher: receptor-like proteins and their roles in immunity and development. Plant Science 274:242-251. https://pubmed.ncbi.nlm.nih.gov/30080610/ Lal, N.K., Nagalakshmi, U., Hurlburt, N.K., Flores, R., Bak, A., Sone, P., Ma, X., Song, G., Walley, J., Shan, L., He, P., Casteel, C., Andrew J. Fisher, A.J., and Dinesh-Kumar, S.P. (2018) Nuclear role of a plant receptor-like cytoplasmic kinase in hormone regulation during innate immunity. Cell Host & Microbe 23:485-497. https://pubmed.ncbi.nlm.nih.gov/29649442/ Zhou, J., Liu, D., Wang, P., Lin, W., Chen, S., Mishev, K., Lu, D., Kumar, R., Vanhoutte, I., He, P., Russinova, E., and Shan, L. (2018) Regulation of Arabidopsis brassinosteroid receptor BRI1 endocytosis and degradation by plant U-box PUB12/PUB13-mediated ubiquitination. Proc Natl Acad Sci U S A. 115: E1906-E1915 https://doi.org/10.1073/pnas.1712251115. Li, F., Li, M., Wang, P. Cox, K. L., Duan, L., Dever, J. K., Shan, L., Li, Z., He, P. (2017). Regulation of cotton (Gossypium hirsutum) drought responses by mitogen‐activated protein (MAP) kinase cascade‐mediated phosphorylation of GhWRKY59. New Phytologist 215: 1462-1475. https://nph.onlinelibrary.wiley.com/doi/full/10.1111/nph.14680 Cox, K. L., Meng, F., Wilkins, K. E., Li, F., Wang, P., Booher, N. J., Carpenter, S. C. D., Chen, L. Q., Zheng, H., Gao, X., Zheng, Y., Fei, Z., Yu, J. Z., Isakeit, T., Wheeler, T., Frommer, W. B., He, P., Bogdanove, A. J., and Shan, L. (2017) TAL effector driven induction of a SWEET gene confers susceptibility to bacterial blight of cotton. Nature Communications. https://www.nature.com/articles/ncomms15588 Mang H., Feng, B., Hu, Z., Boisson-Dernier, A., Franck, C.M., Meng, X., Xu, G., Wang, T., Shan, L., and He, P. (2017) Differential regulation of two-tiered plant immunity and sexual reproduction by ANXUR receptor-like kinases. The Plant Cell 29: 3140–3156. https://doi.org/10.1105/tpc.17.00464 Feng, B., Ma, S., Chen, S., Zhu, N., Zhang, S., Yu, B., Yu, Y., Le, B., Chen, X., Dinesh-Kumar, S.P., Shan, L., and He, P. (2016) PARylation of the forkhead-associated domain protein DAWDLE regulates plant immunity. EMBO Reports 17:1799-1813. https://www.ncbi.nlm.nih.gov/pubmed/27797852