Bachoo, Robert - The University of Texas at Dallas

个人简介

Dr. Robert Bachoo is a physician-scientist in the Department of Neurology and holds joint appointments in the Department of Internal Medicine and the Simmons Comprehensive Cancer Center. He leads the Neuro-Oncology Translational Laboratory in the Simmons Comprehensive Cancer Center, coordinating multidisciplinary basic, translational, and clinical brain tumor-related research. Dr. Bachoo received his MD from the University of Toronto (Ontario, Canada) and his PhD from McGill University (Quebec, Canada). He completed his Neurology training at Tufts University, Boston, where he served as the Chief Resident in Neurology. Following his clinical training, he joined Dr. Ronald Depinho’s laboratory at Dana Farber Cancer Institute, Harvard University, Boston, as a post-doctoral research fellow, while serving as a Clinical Instructor in Neurology Brigham and Women’s Hospital, Harvard University. Dr. Bachoo joined the faculty of Neurology and Neurotherapeutics at UT Southwestern Medical Center in 2006 and was named the Miller Family Professor in Neuro-Oncology. Dr. Bachoo’s research focuses on understanding the fundamental mechanisms that drive malignant brain tumors. A major emphasis of his work is developing accurate models of brain tumors, which include using genetically engineered mouse glioma models (GEMMs) as well as patient-derived xenograft (PDX) models from patients undergoing surgical resection of their tumor at UT Southwestern. His laboratory has generated one of the largest collections of brain tumor PDX models in the country and has pioneered the intra-operative metabolic tracer studies in brain tumor patients undergoing surgery for studying tumor metabolism. These clinically and molecularly annotated mouse models serve as critical discovery platforms to understand fundamental mechanisms that drive brain growth and identify potential therapeutic vulnerabilities. Insights gained from the models have contributed to overturning an 80-year-old dogma about how brain tumors fuel their growth as well as identified novel clinical imaging biomarkers and potential therapeutic targets. In addition to fostering multidisciplinary collaborative research at UTSW, Dr. Bachoo has developed strong inter-institutional collaborations with faculty in the Departments of Biomedical Engineering and Mechanical Engineering (UT Arlington and UT Dallas). Together, his research teams use biophysical approaches to understand how brain tumor cells migrate through the brain tissue, a characteristic which makes these tumors surgically incurable. These projects aim to develop novel strategies to safely and reversibly disrupt the blood-brain-barrier for drug delivery. Dr. Bachoo has authored more than 100 scientific peer-reviewed articles and is reviewer for more than 20 journals. He has served on multiple NIH research study sections, including as a permanent member of the Cellular and Molecular Biology of Glia (CMBG), and on Special Emphasis Panels, including the Cancer Atlas. Education Graduate School McGill University Faculty of Medicine (1989), Experimental Medicine Medical School University of Toronto (1996), Medicine Internship Brigham and Women's Hospital/The Faulkner Hospital (1997), Neurology Residency Tufts University (2000), Neurology

研究领域

Blood Brain Barrier Disruption Brain Tumor Metabolism Malignant Transformation Stem Cell Biology Tumor Cell Migration Tumor Microenvironment

近期论文

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Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles. Gao X, Zhang Z, Mashimo T, Shen B, Nyagilo J, Wang H, Wang Y, Liu Z, Mulgaonkar A, Hu XL, Piccirillo SGM, Eskiocak U, Davé DP, Qin S, Yang Y, Sun X, Fu YX, Zong H, Sun W, Bachoo RM, Ge WP, Cell Rep 2020 Feb 30 8 2489-2500.e5 Mechanical regulation of glycolysis via cytoskeleton architecture. Park JS, Burckhardt CJ, Lazcano R, Solis LM, Isogai T, Li L, Chen CS, Gao B, Minna JD, Bachoo R, DeBerardinis RJ, Danuser G, Nature 2020 Feb 578 7796 621-626 IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma. Kofuji S, Hirayama A, Eberhardt AO, Kawaguchi R, Sugiura Y, Sampetrean O, Ikeda Y, Warren M, Sakamoto N, Kitahara S, Yoshino H, Yamashita D, Sumita K, Wolfe K, Lange L, Ikeda S, Shimada H, Minami N, Malhotra A, Morioka S, Ban Y, Asano M, Flanary VL, Ramkissoon A, Chow LML, Kiyokawa J, Mashimo T, Lucey G, Mareninov S, Ozawa T, Onishi N, Okumura K, Terakawa J, Daikoku T, Wise-Draper T, Majd N, Kofuji K, Sasaki M, Mori M, Kanemura Y, Smith EP, Anastasiou D, Wakimoto H, Holland EC, Yong WH, Horbinski C, Nakano I, DeBerardinis RJ, Bachoo RM, Mischel PS, Yasui W, Suematsu M, Saya H, Soga T, Grummt I, Bierhoff H, Sasaki AT, Nat. Cell Biol. 2019 Aug 21 8 1003-1014 Brain metabolism modulates neuronal excitability in a mouse model of pyruvate dehydrogenase deficiency. Jakkamsetti V, Marin-Valencia I, Ma Q, Good LB, Terrill T, Rajasekaran K, Pichumani K, Khemtong C, Hooshyar MA, Sundarrajan C, Patel MS, Bachoo RM, Malloy CR, Pascual JM, Sci Transl Med 2019 Feb 11 480 Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo. Courtney KD, Bezwada D, Mashimo T, Pichumani K, Vemireddy V, Funk AM, Wimberly J, McNeil SS, Kapur P, Lotan Y, Margulis V, Cadeddu JA, Pedrosa I, DeBerardinis RJ, Malloy CR, Bachoo RM, Maher EA Cell Metab. 2018 Aug Label-free optical detection of action potential in mammalian neurons. Batabyal S, Satpathy S, Bui L, Kim YT, Mohanty S, Bachoo R, Davé DP Biomed Opt Express 2017 Aug 8 8 3700-3713 Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma. Singh DK, Kollipara RK, Vemireddy V, Yang XL, Sun Y, Regmi N, Klingler S, Hatanpaa KJ, Raisanen J, Cho SK, Sirasanagandla S, Nannepaga S, Piccirillo S, Mashimo T, Wang S, Humphries CG, Mickey B, Maher EA, Zheng H, Kim RS, Kittler R, Bachoo RM Cell Rep 2017 Jan 18 4 961-976 Prospective Longitudinal Analysis of 2-Hydroxyglutarate Magnetic Resonance Spectroscopy Identifies Broad Clinical Utility for the Management of Patients With IDH-Mutant Glioma. Choi C, Raisanen JM, Ganji SK, Zhang S, McNeil SS, An Z, Madan A, Hatanpaa KJ, Vemireddy V, Sheppard CA, Oliver D, Hulsey KM, Tiwari V, Mashimo T, Battiste J, Barnett S, Madden CJ, Patel TR, Pan E, Malloy CR, Mickey BE, Bachoo RM, Maher EA J. Clin. Oncol. 2016 Nov 34 33 4030-4039 Acetate is a bioenergetic substrate for human glioblastoma and brain metastases. Mashimo T, Pichumani K, Vemireddy V, Hatanpaa KJ, Singh DK, Sirasanagandla S, Nannepaga S, Piccirillo SG, Kovacs Z, Foong C, Huang Z, Barnett S, Mickey BE, DeBerardinis RJ, Tu BP, Maher EA, Bachoo RM Cell 2014 Dec 159 7 1603-14 Metabolism of [U-13 C]glucose in human brain tumors in vivo. Maher EA, Marin-Valencia I, Bachoo RM, Mashimo T, Raisanen J, Hatanpaa KJ, Jindal A, Jeffrey FM, Choi C, Madden C, Mathews D, Pascual JM, Mickey BE, Malloy CR, DeBerardinis RJ NMR Biomed 2012 Nov 25 11 1234-44 Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors. Marin-Valencia I, Cho SK, Rakheja D, Hatanpaa KJ, Kapur P, Mashimo T, Jindal A, Vemireddy V, Good LB, Raisanen J, Sun X, Mickey B, Choi C, Takahashi M, Togao O, Pascual JM, Deberardinis RJ, Maher EA, Malloy CR, Bachoo RM NMR Biomed 2012 Oct 25 10 1177-86 Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. Marin-Valencia I, Yang C, Mashimo T, Cho S, Baek H, Yang XL, Rajagopalan KN, Maddie M, Vemireddy V, Zhao Z, Cai L, Good L, Tu BP, Hatanpaa KJ, Mickey BE, Matés JM, Pascual JM, Maher EA, Malloy CR, Deberardinis RJ, Bachoo RM Cell Metab. 2012 Jun 15 6 827-37 In vivo MRS measurement of 2-hydroxyglutarate in patient-derived IDH-mutant xenograft mouse models versus glioma patients. Tiwari V, Mashimo T, An Z, Vemireddy V, Piccirillo S, Askari P, Hulsey KM, Zhang S, de Graaf RA, Patel TR, Pan E, Mickey BE, Maher EA, Bachoo RM, Choi C, Magn Reson Med 2020 Jan Radiation-induced DNA damage cooperates with heterozygosity of TP53 and PTEN to generate high grade gliomas. Todorova PK, Fletcher-Sananikone E, Mukherjee B, Kollipara R, Vemireddy V, Xie XJ, Guida PM, Story MD, Hatanpaa K, Habib AA, Kittler R, Bachoo R, Hromas R, Floyd JR, Burma S, Cancer Res. 2019 May Measurement of (13) C turnover into glutamate and glutamine pools in brain tumor patients. Pichumani K, Mashimo T, Vemireddy V, Ijare OB, Mickey BE, Malloy CR, Marin-Valencia I, Baskin DS, Bachoo RM, Maher EA FEBS Lett. 2017 Sep Rapid progression to glioblastoma in a subset of IDH-mutated astrocytomas: a genome-wide analysis. Richardson TE, Snuderl M, Serrano J, Karajannis MA, Heguy A, Oliver D, Raisanen JM, Maher EA, Pan E, Barnett S, Cai C, Habib AA, Bachoo RM, Hatanpaa KJ J. Neurooncol. 2017 Apr Targeting orthotopic gliomas with renal-clearable luminescent gold nanoparticles. Peng C, Gao X, Xu J, Du B, Ning X, Tang S, Bachoo RM, Yu M, Ge WP, Zheng J Nano Res 2017 Apr 10 4 1366-1376 Hepatic gluconeogenesis influences (13)C enrichment in lactate in human brain tumors during metabolism of [1,2-(13)C]acetate. Pichumani K, Mashimo T, Vemireddy V, Kovacs Z, Ratnakar J, Mickey B, Malloy CR, DeBerardinis RJ, Bachoo RM, Maher EA Neurochem. Int. 2016 Mar Brain Tumor Genetic Modification Yields Increased Resistance to Paclitaxel in Physical Confinement. Bui L, Hendricks A, Wright J, Chuong CJ, Davé D, Bachoo R, Kim YT Sci Rep 2016 6 26134 SOX2 Reprograms Resident Astrocytes into Neural Progenitors in the Adult Brain. Niu W, Zang T, Smith DK, Vue TY, Zou Y, Bachoo R, Johnson JE, Zhang CL Stem Cell Reports 2015 Apr