Williamson, Ritchie - University of Bradford

个人简介

BSc (Hons) in Biochemistry, 1996, University of Bath MSc in Neuroscience, 1997, Institute of Psychiatry, King’s College London PhD in Biochemistry, 2001, Institute of Psychiatry, King’s College London Postgraduate Certificate of Higher Education Practice, 2015, University of Bradford 2011- 2013: Postdoctoral Research Associate, College of Life Sciences, University of Dundee 2008 -2011: Postdoctoral Research Associate, Biomedical Research Institute, Ninewells Medical School, University of Dundee 2004 -2008: Postdoctoral Research Associate, MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King’s College London 2001 – 2004: Alzheimer’s Society Research Fellow, Institute of Psychiatry, King’s College London

研究领域

Dementia; Alzheimer’s disease; Ageing; protein O-GlcNAcylation; signalling pathways

近期论文

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Grasso L, Suska O, Davidson L, Gonatopoulus-Pournatzis, Williamson R, Wasmus L, Wiedlich S, Peggie M, Stavridis M.P. and Cowling V.H. mRNA Cap methylation in pluripotency and differentiation. Cell Reports, 16(5): 1352-1365 (2016) Malik B, Fernandes C, Usardi A., Williamson R, Kellie S, Anderton B. H. and Reynolds C. H. Transcriptomic analysis of oligomeric amyloid-β treated primary cortical neurons reveals dysregulation of genes involved in the biosynthesis of steroids and cholesterol , in Microarrays: Principles, Applications and Technologies, (James V Rogers, ed), pp. 269-295. Nova Science Publishers, Inc., New York (2014) Killick R, Ribe EM, Al-Shawi R, Malik B, Hooper C, Fernandes C, Dobson R, Nolan PM, Lourdusamy A, Furney S, Lin K, Breen G, Wroe R, To AWM, Leroy K, Causevic M, Usardi A, Robinson M, Noble W, Williamson R, Lunnon K, Kellie S, Reynolds CH, Bazanet C, Hodges A, Brion JP, Stephenson J, Simons JP and Lovestone S. Clusterin regulates ß-amyloid toxicity via Dickkopf-1 driven induction of the wnt-PCP-JNK pathway. Mol. Psychiatry, 19(1): 88-98 (2014) McNeilly AD, Williamson R, Balfour DJ, Stewart CA and Sutherland C. A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin. Diabetologia, 55(11): 3061-3070 (2012) Williamson R, McNeilly AD and Sutherland C. Insulin resistance in the brain; an old-age or new-age problem? Biochemical Pharmacology, 84(6):737-45. (2012) Malik B, Fernandes C, Killick R, Wroe R, Usardi A, Williamson R, Kellie S, Anderton BH and Reynolds CH. Oligomeric amyloid-ß peptide affects the expression of genes involved in steroid and lipid metabolism in primary neurons. Neurochem Int, 61(3):321-333. (2012) Williamson R, van Aalten L, Mann DMA, Platt B, Plattner F, Bedford L, Mayer J, Howlett D, Usardi A, Sutherland C and Cole AR. CRMP2 hyperphosphorylation is characteristic of Alzheimer’s disease and not a feature common to other neurodegenerative diseases. J Alzheimers Dis, 27(3):615-25. (2011) Usardi A, Pooler AM, Seereeram A, Reynolds CH, Derkinderen P, Anderton B, Hanger DP, Noble W and Williamson R. Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau. FEBS J, 278(16):2927-37. (2011) Scales TM, Derkinderen P, Leung K-Y, Byers HL, Ward MA, Price C, Bird IN, Perera T, Kellie S, Williamson R, Anderton BH and CH Reynolds. Tyrosine phosphorylation of tau by the Src family kinases Lck and Fyn. Mol Neurodegen, 6:12. (2011) Williamson R, Sutherland C. Neuronal membranes are key to the pathogenesis of Alzheimer’s disease: the role of both raft and non-raft membrane domains. Curr Alzheimer Res. 8(2):213-221. (2011) McNeilly AD, Williamson R, Sutherland C, Balfour DJ, Stewart CA. High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task. Behav Brain Res, 217(1):134-141. (2011) Kickstein E, Krauss S, Thornhill P, Rutschow D, Zeller R, Sharkey J, Williamson R, Fuchs M, Kohler A, Glossmann H, Schneider R, Sutherland C, Schweiger S. Biguanide metformin acts on tau phosphorylation via mTor/protein phosphatase (PP2A) signalling. Proc Natl Acad Sci, 107(50):21830-21835. (2010) Williamson R, Thompson AJ, Abu M, Hye A, Usardi A, Lynham S, Anderton BH, Hanger DP. Isolation of detergent resistant microdomains from cultured neurons: detergent dependent alterations in protein composition. BMC Neurosci, 11:120. (2010) Thompson AJ, Williamson R. Protocol for quantitative proteomics of cellular membranes and membrane rafts. Methods Mol Biol, 658:235-53. (2010) Soutar MP, Kim WY, Williamson R, Peggie M, Hastie CJ, McLauchlan H, Snider WD, Gordon-Weeks PR, Sutherland C. Evidence that glycogen synthase kinase-3 isoforms have distinct substrate prepference in the brain. J Neurochem, 115(4):974-83. (2010)