个人简介

1994: Ph.D., University of Bradford 1990: M.Pharm in Clinical Pharmacy, 73% Top rank in the class, University of Bradford 1982: B.Pharm, 1st class, 1st in the order of merit, Nagpur University, India

研究领域

My area of research interest is in gastrointestinal motility and emesis. In the gastrointestinal motility research, I have established many in-vitro techniques. I have developed probably the best model to study highly complex and extremely useful peristaltic reflex in many species including guinea -pigs and mice and in various gastrointestinal regions including the ileum and colon. In the emesis side, our focus had been on developing new antiemetic therapy. We have investigated neurokinin and various other agents in collaboration with different pharmaceutical industries. Another area of expertise in the emesis research had been in the dissociation of emetic potential from the developmental novel compounds. We have worked to dissociate emetic potential from developmental compounds such as PD4 inhibitors with industrial collaborations

GI motility, in vitro studies on isolated gut tissues, peristaltic reflex and emesis

近期论文

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Mitchell NA, Pepperell E, Ociepka S, Brown JD, Witherington J, Tuladhar B, Sanger GJ, Lee K & Cellek S (2009) 5-Hydroxyindalpine, an agonist at the putative 5-HT1P receptor, has no activity on human recombinant monoamine receptors but accelerates distension-induced peristalsis in mouse isolated colon. Neurogastroenterology & Motility 21: 760-e-48 Dass NB, Bassil AK, North-Laidler VJ, Morrow R, Aziz E, Tuladhar BR, Sanger GJ (2007). Neuromedin U can exert colon-specific, enteric nerve-mediated prokinetic activity, via a pathway involving NMU1 receptor activation. British Journal of Pharmacology 150: 502-508 Sanger, GJ, Tuladhar, BR, Brown, J, Aziz, E, Sivakumar, D, Furness JB, (2007). Modulation of peristalsis by NK3 receptor antagonism in guinea-pig isolated ileum is revealed as intraluminal pressure is raised. Autonomic & Autacoid Pharmacology, 27, 105–111 Khan, H, Naylor, RJ, Tuladhar, BR (2006). Pharmacological characterization of endothelin receptors-mediated contraction in the mouse isolated proximal and distal colon. British Journal of Pharmacology 147: 607-611 Sanger, GJ, Tuladhar, BR, Bueno, L, Furness, JB (2006). Defensive and pathological functions of the gastrointestinal NK3 receptor. Vascular Pharmacology 45: 215-220 Sanger, GJ, Tuladhar, BR (2004). The role of endogenous opioids in the control of gastrointestinal motility: predictions from in vitro modelling. Neurogastroenterology and Motility 16: 38-45 Tuladhar, BR, Ge, LB, Naylor, RJ (2003). 5-HT7 receptors mediate the inhibitory effect of 5-HT on peristalsis in the isolated guinea-pig ileum. British Journal of Pharmacology 138: 1210-1214 Tuladhar B.R., Costall B., & Naylor R.J. (2002) Modulation of 5-HT4 receptor function in the rat isolated ileum by fluoxetine: the involvement of endogenous 5-hydroxytryptamine. British Journal of Pharmacology 136: 150-156 Buckley G; Cooper N; Dyke HJ; Galleway F; Gowers L; Gregory JC; Hannah DR; Haughan AF; Hellewell PG; Kendall HJ; Lowe C; Maxey R; Montana JG; Naylor R; Picken CL; Runcie KA; Sabin V; Tuladhar BR; Warneck JBH (2000) 7-methoxybenzofuran-4-carboxamides as PDE4 inhibitors: A potential treatment for asthma. Bioorganic & Medicinal Chemistry Letters, 18, 2137-2140 Tuladhar B.R., M. D. Womack, & Naylor R.J. (2000) Pharmacological characterization of the 5-HT receptor-mediated contraction in the mouse isolated ileum British Journal of Pharmacology, 131, 1716-1722 Montana JG; Cooper N; Dyke HJ; Gowers L; Gregory JP; Hellewell PG; Miotla J; Morris K; Naylor R; Tuladhar B; Warneck JBH (1998). PDE4 inhibitors: New xanthine analogues Bioorganic & Medicinal Chemistry Letters, 8, 2925-2930 Montana JG; Buckley GM; Cooper N; Dyke HJ; Gowers L; Gregory JP; Hellewell PG; Kendall HJ; Lowe C; Maxey R; Miotla J; Naylor RJ; Runcie KA; Tuladhar B; Warneck JBH (1998) Aryl sulfonamides as selective PDE4 inhibitors Bioorganic & Medicinal Chemistry Letters, 8, 2635-2640 Beasley, S.C., Cooper, N., Gowers, L., Gregory, J.P., Haughan, A.F., Hellewell, P.G., Macari, D., Miotla, J., Montana, J.G., Morgan, T., Naylor, R., Runcie, K.A., Tuladhar, B. & Warneck, J.B.H. (1998). Synthesis and evaluation of a novel series of phosphodiesterase IV inhibitors. A potential treatment for asthma. Bioorganic & Medicinal Chemistry Letters, 8, 2629-2634 Tuladhar B.R., Kaisar M. & Naylor R.J. (1997) Evidence for a 5-HT3 receptor involvement in the facilitation of peristalsis on mucosal application of 5-HT in the guinea pig isolated ileum British Journal of Pharmacology, 122, 1174-1178 Singh, L.; Field, M. J.; Hughes, J.; Kuo, B. S.; Suman-Chauhan, N.; Tuladhar, B. R.; Wright, D. S.; Naylor, R. J. (1997). “The tachykinin NK1 receptor antagonist PD 154075 blocks cisplatin-induced delayed emesis in the ferret.” European Journal of Pharmacology, 321, 209-16 Tuladhar, B.R., Costall, B. & Naylor, R.J. (1996) Pharmacological characterisation of the 5-hydroxytryptamine receptor mediating relaxation in the rat isolated ileum British Journal of Pharmacology, 119, 303-310 Tuladhar, B.R., Costall, B. & Naylor, R.J. (1996) 5-HT3 and 5-HT4 receptor-mediated facilitation of the emptying phase of the peristaltic reflex in the marmoset isolated ileum British Journal of Pharmacology, 117, 1679-1684 Costall, B. & Naylor, R.J. & Tuladhar, B.R (1993) 5-HT4 receptor mediated facilitation of the emptying phase of the peristaltic reflex in the isolated guinea-pig ileum. British Journal of Pharmacology, 110, 1572-1578 Yusuff, N.T., York, P., Chrystyn, H., Bramley, P.N., Swallow, R.D., Tuladhar, B.R. & Losowosky, M.S. (1991) Improved bioavailability from a spironolactone beta-cyclodextrin complex. European Journal of Clinical Pharmacology, 40, 507-511