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个人简介

教育及科研工作经历: 2019-中国海洋大学,教授 2016-2018哈佛大学医学院,InstructorofMedicine 2016-2018麻省总医院,AssistantBiologist 2009-2016麻省总医院/哈佛大学医学院,博士后 2004-2009清华大学,博士 讲授课程: 《细胞生物学》(本科)

研究领域

以斑马鱼为主要模式生物,结合遗传学、发育生物学、分子生物学、生物化学等多种手段解析器官形成与再生的细胞与分子生物学机制。 主要研究方向如下:A.胚胎器官发生B.成体器官(心脏)再生C.极端环境海洋生物抗性的分子机制

近期论文

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LanW,LiuS,ZhaoL*,SuY*.(2020)RegulationofDrosophilahematopoiesisinlymphgland:fromadevelopmentalsignalingpointofview.InternationalJournalofMolecularSciences21(15):5246.Galvez-Santisteban,M.,Chen,D.,Zhang,R.,Serrano,R.,Nguyen,C.,Zhao,L.,Nerb,L.,Masutani,E.M.,Vermot,J.,Burns,C.G.,etal.(2019).Hemodynamic-mediatedendocardialsignalingcontrolsinvivomyocardialreprogramming.Elife8.WangL,YangJ,WangH,RanC,SuY,ZhaoL*.(2019)Ahighlyselectiveturn-onfluorescentprobeforthedetectionofAluminumanditsapplicationtobio-imaging.Sensors19(11):2423. ZhaoL,Ben-YairR,BurnsCE,BurnsCG.(2019)EndocardialNotchsignalingpromotescardiomyocyteproliferationintheregeneratingzebrafishheartthroughWntpathwayantagonism.CellReports26(3):546-554.ChiC,WangL,LanW,ZhaoL*,SuY*.(2018)PpV,actingviatheJNKpathway,repressesapoptosisduringnormaldevelopmentofDrosophilawing.Apoptosis23:554-562.ZhaoL,WangL,ChiC,LanW,SuY*.(2017)TheemergingrolesofphosphatasesinHedgehogpathway.CellCommunicationandSignaling15:35-45.HanP,BloomekatzJ,RenJ,ZhangR,GrinsteinJD,ZhaoL,BurnsCG,BurnsCE,AndersonRM,andChiNC.(2016)Coordinatingcardiomyocyteinteractionstodirectventricularchambermorphogenesis.Nature534:700-704.JahangiriL,SharpeM,NovikovN,González-RosaJM,BorikovaA,NevisK,Paffett-LugassyN,ZhaoL,AdamsM,Guner-AtamanB,BurnsCE,BurnsCG.(2016)TheAP-1transcriptionfactorcomponentFosl2potentiatestherateofmyocardialdifferentiationfromthezebrafishsecondheartfield.Development143:113-122.MahmoudA,O’MearaC,GemberlingM,ZhaoL,BryantDM,ZhengRM,GannonJB,CaiL,ChoiWY,EgaczykGF,BurnsCG,BurnsCE,MacraeCA,PossKD,LeeRT.(2015)Nervesregulatecardiomyocyteproliferationandheartregeneration.DevelopmentalCell34:387-399.HarrisonMR,BussmannJ,HuangY,ZhaoL,OsorioA,BurnsCG,BurnsCE,SucovHM,SiekmannAFandLienCL.(2015)Chemokineguidedangiogenesisdirectscoronaryvasculatureformationinzebrafish.DevelopmentalCell33(4):442-454.JangIH,LuYF,ZhaoL,WenzelPL,KumeT,DattaSM,AroraN,GuiuJ,LaghaM,KimPG,SchlaegerTM,ZonLI,GigasA,BurnsCE,DaleyG.(2015)Notch1actsviaFoxc2toinducetheendothelialtohematopoietictransitionduringembryonicdevelopment.Blood125(9):1418-1426.ZhaoL,BorikovaAL,Ben-YairR,Guner-AtamanB,MacraeCA,LeeRT,BurnsCG,BurnsCE.(2014)Notchsignalingregulatescardiomyocyteproliferationduringzebrafishheartregeneration.PNAS111(4):1403-1408.Zheng,X.,Yang,S.,Han,Y.,Zhao,X.,Zhao,L.,Tian,T.,Tong,J.,Xu,P.,Xiong,C.,andMeng,A.(2012).LossofzygoticNUP107proteincausesmissingofpharyngealskeletonandothertissuedefectswithimpairednuclearporefunctioninzebrafishembryos.TheJournalofBiologicalChemistry287,38254-38264.DeaconDC,NevisKR,CashmanTJ,ZhouY,ZhaoL,WashkoD,Guner-AtamanB,BurnsCG,BurnsCE.(2010)ThemiR-143-adducin3pathwayisessentialforcardiacchambermorphogenesis.Development137(11):1887-1896.ZhaoXY,ZhaoL,TianT,ZhangY,TongJ,ZhengXF,MengAM.(2010)Interruptionofcenphcausesmitoticfailureandembryonicdeath,anditshaploinsufficiencysuppressescancerinzebrafish.TheJournalofBiologicalChemistry285(36):27924-27934.TianT,ZhaoL,ZhaoXY,ZhangM,MengAM.(2009)AzebrafishgenetraplineexpressesGFPrecapturingexpressionpatternoffoxj1b.JournalofGeneticsandGenomics36(10):581-589. TianT#,ZhaoL#,ZhangM,ZhaoXY,MengAM.(2009)Bothfoxj1aandfoxj1bareimplicatedinleft-rightasymmetricdevelopmentinzebrafishembryos.BiochemicalandBiophysicalResearchCommunications380(3):537-542.ZhaoL#,ZhaoXY#,TianT#,LuQL,NirmaS,WuD,KuangZ,ZhengXF,HanYC,YangSY,ZhangCM,MengAM.(2008)Heart-specificisoformoftropomyosin4isessentialforheartbeatinzebrafishembryos.CardiovascularResearch80(2):200-208.

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