个人简介

中国海洋大学“青年英才工程”第一层次特聘教授 主要成果： 发表J. Med. Chem.、Euro. J. Med. Chem.、Org. Lett.等SCI论文20余篇，其中第一作者(含共一)SCI文章12篇；申请专利8项，授权2项；获得美国德克萨斯大学颁发的Herin转化研究奖“Herin Translational Research Award”；受邀多次为Cancers和Cells等杂志审稿人。

研究领域

以神经系统疾病、肿瘤和炎症等人类重大疾病为导向，运用基于天然产物和老药新用的新型小分子药物发现策略，围绕钠通道、GPCR 和cAMP 信号转导通路为靶标，进行分子靶向的药物先导化合物发现及其作用机制研究

基于海洋天然产物的药物先导物发现

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.P. Wang, D. van der Hoeven, N. Ye, H. Chen, Z. Liu, X. Ma, D. Montufar-Solis, K. M. Rehl, K. Cho, S. Thapa, W. Chen, R. van der Hoeven, J. A. Frost, J. F. Hancock, J. Zhou. Scaffold repurposing of fendiline: identification of potent KRAS plasma membrane localization inhibitors. Eur. J. Med. Chem. 2021, 217, 113381. 2.P. Wang, D. E. Felsing, H. Chen, S. J. Stutz, R. E. Murphy, K. A. Cunningham, J. A. Allen, J. Zhou. Discovery of Potent and Brain Penetrant GPR52 Agonists that Suppress Psychostimulant Behavior. J. Med. Chem. 2020, 63, 13951-13972. 3.P. Wang, P.A. Wadsworth, N. M. Dvorak, A. K. Singh, H. Chen, Z. Liu, R. Zhou, L. M. F. Holthauzen, J. Zhou, F. Laezza. Design, Synthesis, and Pharmacological Evaluation of Analogs Derived from the PLEV Tetrapeptide as Protein-Protein Interaction Modulators of Voltage-Gated Sodium Channel 1.6. J. Med. Chem. 2020, 63, 11522-11547. 4.P. Wang, U. Luchowska-Stańska, B. V. Basten, H. Chen, Z. Liu, J. Wiejak, P. Whelan, D. Morgan, E. Lochhead, G. Barker, H. R., S. J. Yarwood, J. Zhou. Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators.J. Med. Chem. 2020, 63, 5159-5184. 5.P. Wang, D. E. Felsing, H. Chen, S. R. Raval, J. A. Allen, J. Zhou. Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists. ACS Med. Chem. Lett. 2019, 10, 792-799. 6.Y. Wang,# P. Wang,# Y. Wang, G. Yang, A. Zhang, Z. Miao. An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy. J. Med. Chem. 2016, 59, 9575-9598. 7.P. Wang, S. Song, Z. Miao, G. Yang, A. Zhang. InBr3-Mediated One-Pot Synthesis of 2-(Polyhydroxylatedalkyl)-N-aryl-/-alkylpyrroles from 1,2-Cyclopropa-3-pyranone and Amines. Org. Lett. 2013, 15, 3852-3855.