刘志清 - 中国海洋大学 - 海洋生物多样性与进化研究所

个人简介

中国海洋大学“青年英才工程”第一层次特聘教授主要成果：发表SCI论文20余篇，其中第一作者(含共一)SCI文章15篇；申请专利7项，获授权2项；获得美国克罗恩病和炎性肠病基金会(Crohn’s & Colitis Foundation of America, CCFA)的Research Fellowship Award资助；参编两部著作章节；多次受邀为RSC Advance, Bioorganic & Medicinal Chemistry等杂志审稿人。

研究领域

从事海洋天然产物分子结构、生物活性多样性研究，作用机制以及先导化合物的发现

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1)Liu, Z.*, Wang, P., Wold, E.A., Song, Q., Zhao, C., Wang, C.* and Zhou, J.* Small-Molecule Inhibitors Targeting the Canonical WNT Signaling Pathway for the Treatment of Cancer. J. Med. Chem.,2021, 64 (8), 4257-4288. 2)Liu, Z.; Chen, H.; Wang, P.; Li, Y.; Wold, E. A.; Leonard, P. G.; Joseph, S.; Brasier, A. R.; Tian, B.; Zhou, J. Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation. J. Med. Chem., 2020, 63, 5242-5256. 3)Niu, Q.#; Liu, Z.#; Alamer, E.; Fan, X.; Chen, H.; Endsley, J.; Gelman, B. B.; Tian, B.; Kim, J. H.; Michael, N. L.; Robb, M. L.; Ananworanich, J.; Zhou, J.; Hu, H. Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV. J. Clin. Invest. 2019, 129, 3361-3373. (#co-first author) 4)Liu, Z.; Tian, B.; Chen, H.; Wang, P.; Brasier, A. R.; Zhou, J. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur. J. Med. Chem. 2018, 151, 450-461. 5)Tian, B.#; Liu, Z.#; Yang, J.; Sun, H.; Zhao, Y.; Wakamiya, M.; Chen, H.; Rytting, E.; Zhou, J.; Brasier, A. R. Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation. Cell Rep. 2018, 23, 1138-1151. (#co-first author)