Nasim, Talat - University of Bradford

个人简介

2000: PhD in Biochemistry and Applied Molecular Biology, University of Manchester, previously known as UMIST, UK) 2013: Visiting Senior Research Fellow,, King’s College London 2008: Founder and Chief Adviser (Honorary), Centre for Health, Agriculture and Socio-economic Advancements (CHASA), Bangladesh 2008 -2013: Senior Research Fellow, NIHR Comprehensive Biomedical Research Centre, Faculty of Translational Medicine, & Dept. of Medical and Molecular Genetics, King’s College London, England 2006 - 2008: Research Associate, Dept. of Medical and Molecular Genetics, King’s College London, England & Dept. of Genetics, University of Leicester, England 2000-2006: Research Associate, Dept. of Biochemistry, University of Leicester, England 1994-1996: Post-graduate Research Fellow, University of Geneva, Switzerland

研究领域

Translational Medicine, Pulmonary Hypertension, Genetic Disorders, Alternative Splicing, Personalized Therapy and Drug Discovery

近期论文

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Jing Hu, Alireza Khodadadi-Jamayran, Miaowei Mao, Kushani Shah, Zhenhua Yang, Talat Nasim, Zefeng Wang, and Hao Jiang. AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors.Nature Communications (Accepted). M. Brioschi, S. Lento, S. Barcella, M.T. Nasim, S. Ghilardi, S. Barbieri, E. Tremoli and C. Banfi. Data for proteomic analysis of murine cardiomyocytic HL-1 cells treated with siRNA against tissue factor. Data Brief. ; 25;3:117-9, 2015 S. Lento, M. Brioschi, S. Barcella, M.T. Nasim, S. Ghilardi, S. Barbieri, E. Tremoli and C. Banfi. Proteomics of tissue factor silencing in cardiomyocytic cells reveals a new role for this coagulation factor in splicing machinery control. J Proteomics.;119:75-89, 2015 T. Ogo, H.M. Chowdhury, R. Randall, L. Long, J. Yang, R. Schumerly, N.W. Morrell, R.C. Trembath and M.T. Nasim. Inhibition of the overactive TGFβ signalling by prostacyclin analogues in pulmonary arterial hypertension (PAH). (American Journal of Respiratory Cell and Molecular Biology, Feb 2013) (Impact factor 5.1), 2013 M.A Siddiqui, T. Ogo and M.T. Nasim. Pulmonary Arterial Hypertension: molecular genetic basis and emerging treatments (Invited review). AKMC J 3(2): 30-33, 2012 M.T. Nasim, T. Ogo, H.M. Chowdhury, L. Zhao, C.N. Chen, C. Rhodes, and R.C. Trembath. BMPR-II deficiency elicits anti-apoptotic and pro-proliferative responses through the activation of TGFβ-TAK1-MAPK pathways in PAH. Human Mol Genetics (Impact factor 7.6) (21):2548-58, 2012 T. Graubert, D Shen, Li Ding, T, Okeyo-Owuor, J. Shao, C. Lunn, K. Krysiak, D. Koboldt, D. Larson, M. McLellan, D. Dooling, C. Harris, R. Maupin, R. Fulton, H. Schmidt, J. Kalicki-Veizer, M. O’Laughlin, M. Grillot, S. Heath, T. Nasim, D. Link, M. Tomasson, P. Westervelt, J. DiPersio, E. Mardis, T. Ley, R. Wilson, and M. Walter. Recurrent mutations in the U2AF1 splicing factors in myelodysplastic syndromes. Nature Genetics (Impact factor 35.5) 44(1):53-7(doi 10.1038/ng.1031), 2012 Katiyar S, Maria A, Covarrubias Y, Casimiro M.C, Zhou J, Jaio X, Hyslop T, Nasim T, Fortina P, Pestell R. Mamary gland selective excision of c-jun identifies its role in mRNA splicing Cancer Research (Impact factor 7.8); 72(4):1023-34), 2011 M T. Nasim, T. Ogo, M. Ahmed, R. Randall, H.M. Chowdhury, K. Snape, T. Bradshaw, F. Soubrier, I. Jackson, G. Lord, M. Humbert, N. Morrell, R. C. Trembath and R. Machado,. Molecular genetic characterization of Smad signalling molecules in pulmonary arterial hypertension (PAH). Human Mutation (Impact factor 5.6) 12:1385-89, 2011 Suraweera A, Lim Y, Woods R, Birrell GW, Nasim T, Becherel OJ, Lavin MF. Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation. Hum Mol Genet. (Impact factor 7.6) (18):3384-96, 2009 M.T. Nasim, A.G. Ghouri, B.P. Patel, V. James, N. Rudarakanchana, N. Morrell and R.C. Trembath. Stoichiometric imbalance in the receptor complex contributes to the dysfunctional BMPR-II mediated signalling in pulmonary arterial hypertension. Hum Mol Genet (Impact factor 7.6) (11):1683-94, 2008 M.T. Nasim and R.C. Trembath. A double reporter assay to determine the efficiency of protein-protein interactions in mammalian cells. Nature Protocols Network, 2007 (DOI: 10.1038/nprot.2007.238) M.T. Nasim and I. C. Eperon. A double-reporter splicing assay to determine splicing efficiencies in mammalian cells. Nature Protocols (Impact factor 9.9)1(2):1022-1028, 2006